Serum MRP Level Correlates With Severity of HIV Infection

Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.

Serum MRP Level Correlates With Severity of HIV Infection

Reuters Health Information Services (12/29/97)

Abstract: Swiss researchers have concluded that advanced HIV infection is associated with increases in the level of macrophage inhibitory factor-related protein (MRP) 8/14 and with declines in MRP 8 serum levels. Dr. Florian Strasser of Inselspital Bern and colleagues analyzed serum concentrations of MRP 8, MRP 14, and MRP 8/14 in 184 HIV-infected patients and 50 HIV- free controls. The researchers, who report their findings in the Journal of Acquired Immune Deficiency Syndrome and Human Retrovirology, note the MRP 8/14 rates were significantly higher in AIDS patients than in those in the earlier phases of disease, but add that it is still not certain if HIV directly affected MRP releases and expression.

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