Host Factors and the Pathogenesis of HIV-Induced Disease

Important note: Information in this article was accurate in 1996. The state of the art may have changed since the publication date.

Host Factors and the Pathogenesis of HIV-Induced Disease

Nature (12/12/96) Vol. 384, No. 6609, P. 529
Fauci, Anthony S.

Abstract: A variety of host and viral factors effect HIV infection and disease progression. In a review of the research on these factors, Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases, focuses on the balance between host factors that stimulate HIV and those that suppress the virus. This balance determines the net level of viral replication and the consequent course of disease. Activation of the immune system by opportunistic pathogens like Mycobacterium tuberculosis result in increased HIV replication and accelerated disease progression. Furthermore, cellular activation and the expression of HIV-inducing cytokines are also associated with an immune response. HIV- suppressing cytokines have also been identified, as well as chemokine receptors used by HIV as co-receptors. A genetic defect in one of HIV's co-receptor, found in 20 percent of western European Caucasians, was found to offer limited protection against HIV infection. These findings have important implications for potential treatment and prevention strategies, Fauci concludes.

961223
AD962434

Copyright © 1996 - Information, Inc., Bethesda, MD. The CDC National Center for HIV, STD and TB Prevention provides the following information as a public service only. Providing synopses of key scientific articles and lay media reports on HIV/AIDS, other sexually transmitted diseases and tuberculosis does not constitute CDC endorsement. This daily update also includes information from CDC and other government agencies, such as background on Morbidity and Mortality Weekly Report (MMWR) articles, fact sheets, press releases and announcements. Reproduction of this text is encouraged; however, copies may not be sold, and the CDC HIV/STD/TB Prevention News Update should be cited as the source of the information. Contact the sources of the articles abstracted below for full texts of the articles.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Elton John AIDS Foundation, the National Library of Medicine, AIDS Walk of Orange County, and donations from users like you.

Always watch for outdated information. This article first appeared in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1996. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content.