Isis Drops Human Trials of a Genetic Drug

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Isis Drops Human Trials of a Genetic Drug

New York Times (12/29/95) P. D2
Fisher, Lawrence M.

Isis Pharmaceuticals has suspended clinical trials of a potential treatment for genital warts, an antisense compound known as Isis 2105, because it claims that the results and potential market do not merit further development. The company's shares dropped 37.5 cents to $13.25. According to analysts, the minimal decline reflects the company's attempts to prepare investors for a setback with the drug, as well as the promise of other Isis drugs currently being tested. These drugs include treatments for cytomegalovirus retinitis, for kidney transplant rejection, and for inflammation. Stanley Crooke, Isis chairman and CEO, said that although Isis 2105, when used with cryosurgery, had demonstrated antiviral activity, the drug was not strong enough and would likely need to be reformulated.

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