Cytotoxic T Lymphocyte Lysis Inhibited by Viable HIV Mutants

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Cytotoxic T Lymphocyte Lysis Inhibited by Viable HIV Mutants

Science (11/24/95) Vol. 270, No. 5240, P. 1360
Meier, Ute-Christiane; Klenerman, Paul; Griffin, Philip

Although it is not fully understood why the immune response fails to destroy HIV in most patients, the mutation of viral antigens may play a role. Meier et al. report that they observed significant inhibition of specific antiviral lysis when cytotoxic T lymphocytes were engaged in CD4-positive cells that were acutely infected with HIV carrying natural variant epitopes in reverse transcriptase. According to the researchers, mutant viruses that can produce such transactive effects could favor the persistence of several variants of HIV, despite the presence of an active and specific immune response.

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