Potent New Weapon

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Potent New Weapon

Los Angeles Times--Washington Edition (12/15/95) P. A9
Cimons, Marlene

Protease inhibitors are an apparently effective new class of AIDS drugs that attack HIV at a later stage than the family of drugs known as nucleoside analogs do and cause a remarkable drop in the amount of virus detectable in HIV-infected patients' blood. However, like the older nucleoside analogs, such as AZT, ddI, ddC, D4T, and 3TC, protease inhibitors are also subject to drug resistance when the virus mutates into new forms. When taken in combination with other drugs, however, protease inhibitors can blunt the virus' ability to resist these and other drugs. At present, at least six protease inhibitors are undergoing various stages of development, and researchers predict that even stronger versions of this class of drugs may be in development soon.

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