Work on Mild H.I.V. Type May Aid Search for AIDS Vaccine

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Work on Mild H.I.V. Type May Aid Search for AIDS Vaccine

New York Times (12/15/95) P. A38
Hilchey, Tim

Mount Sinai Medical Center researchers say they have identified a relatively mild strain of HIV that can inhibit reproduction in a more virulent strain. In the Journal of Molecular Medicine, Dr. Jay Rappaport--an associate professor of immunobiology at Mount Sinai--and others, including researchers at the National Institutes of Health, report that in the laboratory, HIV-2 inhibited HIV-1 at its ends, in regions known as the long terminal repeats. Dr. Rappaport suggested that HIV-2 may interfere with the molecular interactions that must occur in those regions before mass replication of HIV-1 is possible. He noted, however, that the inhibitory effect "may be a direct effect of the HIV-2 virus or it could be a result of some interaction with the cell itself that activates a cellular mechanism that inhibits HIV-1 replication." In an accompanying editorial, Dr. Z.N. Bernemean of Ziekenhuis University in Belgium warned that there was still a great deal unknown about the interaction between the two strains of HIV.

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