Esophageal Disease Profiled

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Esophageal Disease Profiled

AIDS Clinical Care (09/95) Vol. 7, No. 9, P. 77

A prospective study in Atlanta cataloged the etiology and course of esophageal ulceration in HIV-positive individuals who were diagnosed between 1990 and 1994. All 100 subjects had symptomatic esophageal ulcer identified on endoscopy, and the majority had longstanding HIV infection, with an average of 15 CD4 cells. The researchers tabulated syndromes including cytomegalovirus esophagitis in 50 subjects, herpes simplex esophagitis in nine, idiopathic esophageal ulceration in 41, and gastroesophageal reflux-associated ulceration in four. For the most part, clinical and endoscopic response to therapy was good, although 27 patients relapsed. These findings demonstrate the shifting microbial etiologies of HIV- related disorders and the need for specific tissue diagnoses.

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