It's a Wrap

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

It's a Wrap

Advocate (02/22/94) No. 649, P. 29 (Bull, Chris)

The final draft of the Concorde study, the most comprehensive inquiry ever into the efficacy of AZT, is being prepared for publication. Because preliminary results presented last April suggest that the drug does little to delay the progression of AIDS, physicians warn that the final conclusions--which are expected to mirror the originals--are likely to leave many questions about AZT's effectiveness unanswered. A spokesperson for Burroughs Wellcome Co., the drug's manufacturer, insists that the company's position on AZT as an AIDS treatment will likely remain unchanged despite the Concorde study. Observers of AZT sales, however, predict that publication of the final report will have much of the same effect as the preliminary results: a call for stepped-up development of alternative treatments and a decline in use of the drug. Physicians say they are looking to another study, known as the Compact study, to provide clearer information about the efficacy of HIV. The Concorde study is a British- French project that followed some 1,800 HIV-positive subjects, half of whom were administered AZT and the remaining half of whom received placebos. The study compared the rate at which the two groups developed AIDS.

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