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Cellular Immune Response to Common Mycobacterial Antigens in Subjects Seropositive for Trypanosoma Cruzi

Lancet (12/03/94) Vol. 344, No. 8936, P. 1540
Bottasso, O.A.; Ingledew, N.; Keni, M. et al

Researchers studied the impairment of immune responses in patients in the silent stage of Chagas' disease, which is caused by Trypanosoma cruzi and affects about 20 million people in Latin America. Bottasso et al used quadruple skin- testing with new tuberculins in 37 adults who were symptom- free but seropositive for T. cruzi, and in 37 matched seronegative controls. While none of the seropositive group responded to them, nearly one-fifth of the control group responded, with variable specificity, to common mycobacterial antigens. The researchers suggest that the loss of response to mycobacterial antigens may influence the course of Chagas' disease. Individuals who are infected with T. cruzi may be more susceptible to tuberculosis, leprosy, and HIV infection-- all of which are associated with immune unresponsiveness.


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