Going Off the Beaten Path to Track Down Clues about AIDS

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Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Going Off the Beaten Path to Track Down Clues about AIDS

New York Times (12/20/94) P. C3
Altman, Lawrence K.

Because Dr. Yuan Chang and Dr. Patrick S. Moore were new to the field, they were more able to try wild ideas than many others working in established laboratories. Together, they form the husband-and-wife team that announced last week that they had detected fragments of a possible new virus and that the agent might cause Kaposi's sarcoma (KS). Chang and Moore explored the Cold Spring Harbor Laboratory technique, known as representational difference analysis, which compares DNA in cells from diseased and normal tissues of the body, and pinpoints significant differences in their chemical sequences. Working with colleague Dr. Melissa S. Pessin, the team hoped to spot genetic differences that might be the inserted genetic material of an infectious agent. While the discovery raised many questions, the doctors' conclusions emphasize the need to grow the full virus in the laboratory, to identify it through an electron microscope, and to prove its relationship to KS. A blood test to diagnose the disease is also needed. A blood test might also answer questions about KS and AIDS if frozen samples from AIDS patients are screened.

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