"Cellular Proteins Bound to Immunodeficiency Viruses: Implications for" Pathogenesis and Vaccines

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

"Cellular Proteins Bound to Immunodeficiency Viruses: Implications for" Pathogenesis and Vaccines

Science (12/18/92) Vol. 258, No. 5090, P. 1935
Arthur, Larry O. et al.

Abstract: Cellular proteins linked with immunodeficiency viruses play a primary role in infection and pathogenesis, write Larry O. Arthur et al. of the National Cancer Institute--Frederick Cancer Research and Development Center in Frederick, Md. Cellular proteins associated with immunodeficiency viruses were identified by determination of the amino acid sequence of the proteins and peptides present in sucrose density gradient-purified HIV-1, HIV-2, and simian immunodeficiency virus (SIV). B2 microglobulin (B2m) and the a and B chains of human lymphocyte antigen (HLA) DR were present in virus preparations at one-fifth the concentration of Gag on a molar basis. Antisera to HLA DR, B2m as well as HLA class I precipitated intact viral particles, suggesting that these cellular proteins were physically associated with the surface of the virus. Whether the cellular proteins are components of the viral envelope acquired during budding or are acquired after budding by specific associations is an important mechanistic consideration that can now be addressed. It is likely that immune responses to HLA DR, HLA class I, or B2m (or to all three cellular proteins) were involved in the protection against SIV infection after immunization with uninfected human cells. These proteins should be considered in elucidation of the steps involved in infection, design of vaccines, preparation of experimental virus-challenge stocks, and determination of the pathological mechanisms of immunodeficiency viruses, the researchers conclude.
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