"Invasive Haemophilus Influenzae Infections in Men With HIV Infection"

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

"Invasive Haemophilus Influenzae Infections in Men With HIV Infection"

Journal of the American Medical Association (12/16/92) Vol. 268, No. 23, P. 3350
Steinhart, Rachel et al.

Abstract: Men with HIV infection or AIDS are susceptible to invasive Haemophilus Influenzae infections, including H influenzae b, but such infections are still rare in this population, write Rachel Steinhart et al. of the University of California--Berkeley. The researchers conducted a study of all men aged 20 to 49 residing in San Francisco with invasive H influenzae disease. During the 3-year time period from January 1, 1989 through December 31, 1991, there were 17 men who qualified for the study. In all 17 patients, H influenzae was recovered from blood. Among the 17 patients, 16 either had AIDS or were known to be infected with HIV, yielding annual cumulative incidence rates for invasive H influenzae infections among men with AIDS, HIV-infected men without AIDS, and all HIV-positive men of 79.2, 14.6, and 22.7 per 100,000, respectively. However, only 33 percent of cases were due to serotype b. The corresponding rates for invasive H influenzae b disease were 11.3 and 7.6 per 100,000. The researchers conclude that rates of invasive H influenzae disease they observed in HIV-positive men, particularly those with a prior AIDS-defining illness is approximately 100 times the rate of invasive H influenzae disease previously reported in all adults.

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