"Tuberculosis and HIV Infection" CDC Daily UpdateImportant note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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"Tuberculosis and HIV Infection"

New England Journal of Medicine (12/26/91) Vol. 325, No. 26, P. 1883
Cathebras, P.J.


Abstract: The hypothesis that M. tuberculosis accelerates HIV infection should be further investigated, writes P.J. Cathebras of the Institute of Community and Family Psychiatry, Montreal, Canada. In the June 6 issue of the New England Journal of Medicine, Barnes et al. are reluctant to address the relationship between tuberculosis and HIV infection in developing countries, especially in sub-Saharan Africa. In a 1987-1988 survey in Bangui, Central African Republic, the seroprevalence of HIV among patients with newly diagnosed tuberculosis was 31 percent, compared to 8 percent in the general adult population. Antituberculosis drugs should be provided in primary care settings, as tuberculosis is the most common treatable disease associated with HIV infection. In addition, the high prevalence of both HIV infection and tuberculosis make it unadvisable to administer isoniazid chemoprophylazis to patients infected with both diseases because it could result in isoniazid-resistant organisms, the researchers conlude.


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