"AIDS Vaccine: Hope and Despair"

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

"AIDS Vaccine: Hope and Despair"

Lancet (12/22-29/90) Vol. 336, No. 8730, P. 1545

Abstract: Recent trial results from the U.K. National Institute for Biological Standards and Control and the Centre for Applied Microbiology and Research indicate that a vaccine to prevent and possibly cure AIDS will be developed, write the editors of the Lancet. The researchers set up a system to detect SIV infection and monitor T4 cells in macaques, challenged them with a vaccine containing all the major viral antigens expressed on the cell surface, and achieved impressive results. Eight macaques were completely protected from infection, whereas all seven unvaccinated animals contracted SIV. Stott and colleagues also tried to use the vaccine therapeutically after infection, with little success, but the results of two prophylactic studies provide solid hope for a successful vaccine. However, Jonathan Mann has said past difficulty in getting hepatitis B to needy populations casts grave doubts on an HIV vaccine's availability in developing countries, although he has suggested a unique plan to get major pharmaceuticals to produce a vaccine at cost.

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