"Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1"

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

"Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1"

Science (12/14/90) Vol. 250, No. 4987, P. 1593
Giulian, Dana, et al.

Abstract: Activated mononuclear phagocytes (microglial cells, macrophages, and others), the principle targets for HIV-1 in the central nervous system (CNS), may release toxic substances that destroy neurons and cause the neurologic complications associated with AIDS, write Dana Giulian and colleagues of the Baylor College of Medicine, Houston. In rats and chicks, HIV-infected mononuclear phagocytes continuously released poisons that affected neurons not in direct contact with the cells. Activation may result from a variety of signals and produce a similar chain of events that cause loss of neurons in stroke and trauma as well as AIDS. AIDS encephalopathy and neurological damage from other diseases may result from the same underlying mechanisms, although further investigation in animals and humans is necessary, they write. These data indicate that suppression of mononuclear phagocyte activation, blocking synthesis of neurotoxins, and blocking the relevant neuronal receptors may combat the neurologic complications of AIDS, they conclude.

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