"Progress Is Seen Toward Vaccine for AIDS Strains"

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

"Progress Is Seen Toward Vaccine for AIDS Strains"

Wall Street Journal (12/14/90), P. B9
Chase, Marilyn

Abstract: Researchers have used a chain of amino acids in the V3 loop that is conserved among many strains of HIV to develop a vaccine against the virus. This part of the V3 loop, which sits on the outer coat and provokes a strong immune response, remained constant in 60 percent of 245 virus samples, researchers said. Researchers found that a synthetic version of this amino acid chain evoked cross-neutralization of two widely divergent HIV strains in laboratory animals. Cross-neutralization is an important goal in AIDS vaccine development because HIV varies so widely and people need protection against random strains, researchers say. Researchers Kashi Javaherian of Repligen Corp. and Thomas Matthews of Duke University published their findings in the journal Science. The authors acknowledged that the next challenge will be to neutralize "escape mutants," or HIV variants that evolve to elude the immune system.

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