"No T-Cell Tyrosine Protein Kinase Signalling or Calcium Mobilization" After CD4 Association with HIV-1 or HIV-1 gp120 CDC Daily UpdateImportant note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.
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"No T-Cell Tyrosine Protein Kinase Signalling or Calcium Mobilization" After CD4 Association with HIV-1 or HIV-1 gp120

Nature (12/06/90) Vol. 348, No. 6301, P. 557
Horak, Ivan D., et al.

Abstract: Binding of HIV gp120 to CD4+ cells, previously thought to mimic interactions that trigger T cell activation pathways, fails to elicit the specific tyrosine kinase activation and signalling and changes in intracellular calcium concentration that would be requirements for virus production, write Ivan Horak and colleagues of the National Cancer Institute. Binding and crosslinking of HIV-1 gp120 does not stimulate signal transduction pathways, so non-proliferating T cells can be infected with HIV. Early HIV interactions with dormant T cells may not generate signal requirements for virus production, contrary to other reports demonstrating that CD4 dependent binding to T cells results in increased calcium mobilization and other activation signals, the researchers report.


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