"Multiple Drug Reactions in a Patient with AIDS"

Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

"Multiple Drug Reactions in a Patient with AIDS"

Lancet (12/16/89) Vol. 2, No. 8677, P. 1455
Wignants, H., et al.

Abstract: Writing in response to a report by Drs. Ong and Mandal (Lancet, Oct. 21), H. Wignants and colleagues from the Institute of Tropical Medicine, Antwerp, Belgium, discuss the case of a 40-year-old gay man with HIV infection and Kaposi's sarcoma who displayed a hypersensitivity to several antibiotics. In June 1989, both co-trimoxazole and amoxycillin, taken to treat Salmonella typhimurium infection, caused a generalized rash. Later, after treatment with ofloxacin, the man developed a generalized maculopapular rash, at which time the doctors replaced oxfloxacin with chloramphenicol. After disappearing for a few days, the rash recurred and the patient developed Stevens-Johnson syndrome. Following the discontinuation of all tuberculostatic drugs, the fever disappeared and the mucotaneous lesions gradually healed. Megalumine ioxitalamate later caused a sustained rash with high fever. In four of 33 patients with AIDS, the researchers report, they have seen a drug reaction against at least two drugs.

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