"Infection of the SCID-hu Mouse by HIV-1"

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Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

"Infection of the SCID-hu Mouse by HIV-1"

Science (12/23/88) Vol. 242, No. 4885, P. 1684
Namikawa, R., et al.

Abstract: Researchers from Stanford University report on the inoculation with HIV-1 of SCID-hu mice that had human fetal thymic or lymph node implants. The virus replicated in the human lymphoid organs in time- and dose-dependent fashion. In most infected cells, combination immunohistochemistry and in situ hybridization showed only viral RNA tran s. However, some cells displayed both detectable viral tran s and viral protein. The studies of the mice give researchers the opportunity to follow an acute infection of human lymphoid organs with HIV-1, the researchers report.
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AD880441

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