"Researchers Report Discoveries About AIDS"

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Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

"Researchers Report Discoveries About AIDS"

United Press International (12/23/88)

Abstract: Discoveries about the "tat" gene in HIV may lead to major advances in AIDS research, according to MAUrice Green and PAUl Lowenstein of the St. Louis University Medical Center. The gene regulates the virus and is essential for HIV replication. In the lab, researchers say, a chemically synthesized version of the tat regulatory gene attached itself to the outside of a cell and "trans-activated," or turned on, HIV within the cell. The researchers, who report on their work in the Dec. 23 issue of Cell magazine, claim this is the first time an extra-cellular protein has been demonstrated to alter gene expression within the cells. The researchers, who believe the gene may trigger the activation of latent HIV, hope to find compounds that are effective in subverting the small part of the gene that carries the "trans-activation" function. They say tat could turn out to be HIV's "Achilles heal."
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