"AIDS and Neuroleptic Malignant Syndrome" CDC Daily UpdateImportant note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.
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"AIDS and Neuroleptic Malignant Syndrome"

Lancet (12/24-31/88) Vol. 2, No. 4826/4827, P. 1488
Breitbart, William, et al.

Abstract: William Breitbart of Memorial Sloan-Kettering Cancer Center and Cornell Medical College and his colleagues report on what they believe to be the first three reported cases in people with AIDS-Related Dementia of neuroleptic malignant syndrome caused by the dopamine-blocking effects of potent neuroleptic drugs. In all three patients, symptoms of the syndrome appeared following the administration of oral haloperidol. Cessation of the drug and the addition of other drugs resolved the problems. Although researchers have recommended low-dose haloperidol for the management of organic mental disorders in AIDS patients, such patients may have increased susceptibility to the dopamine-blocking effects of potent neuroleptics, Breitbart and colleagues report.
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