"Bronchial Bleeding with Nebulised Pentamidine"

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Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

"Bronchial Bleeding with Nebulised Pentamidine"

Lancet (12/24-31/88) Vol. 2, No. 8626/8627, P. 1488
Miller, R. F.

Abstract: In response to other letters on the side effects of nebulized pentamidine to treat Pneumocystis carinii pneumonia in people with AIDS, R.F. Miller and S.J.G. Semple of University College and Middlesex School of Medicine at Middlesex Hospital in London report on bronchial bleeding as an additional side effect. The researchers observed some bleeding in 5 of 16 patients in an open study. They say that the cough and bronchoconstriction noted by other researchers may be induced by the physiochemical properties of pentamidine. Miller and Semple suggest further study into buffering pentamidine to raise its pH and increasing the osmolality of the nebuliser solution.
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AD880017

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