AEGiS-APPJ: Opinion & Commentary: Noncompliance in Clinical Trials: I. Subjects AIDS & Public Policy JournalImportant note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.
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Opinion & Commentary: Noncompliance in Clinical Trials: I. Subjects

AIDS & Public Policy Journal 5, no. 2 (Spring 1990): 94-96
Alvin Novick

In classical clinical trials, involving altruistic subjects, we have had few well-documented evaluations of subject compliance with trial protocols. We may guess that subjects have often cooperated when they felt well-treated. The principal source of noncompliance, especially secretive or unarticulated noncompliance, would probably have been carelessness or inconvenience. Two new kinds of trial design may help to ensure compliance: community-based clinical trials and parallel-track trials. Subjects cannot be expected to articulate all their needs and expectations clearly. Collaboration between scientists, potential subjects of many sorts, and subject advocates can establish sound research designs. Concerns regarding noncompliance are best approached through broad cooperation, consultation, and open recognition of the poisonous fruits of social oppression and exclusion.
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