ADAP drugs: pentoxifylline

pentoxifylline (Trental)

Drug description
Pentoxifylline is used to lower blood levels of the cytokine called tumor necrosis factor (TNF). TNF is produced by immune system cells in response to infection. When TNF is present in significant amounts in the bloodstream, severe weight loss may occur. TNF also interferes with the antiretroviral effects of AZT and ddC. However, several studies have found no benefit to the use of pentoxifylline in HIV disease.

Side effects
Headache, tremor, dizziness, bad digestion, nausea, and vomiting are the most common side effects.

Dosage
Adults take 400 mg 3 times per day.

How long it may take to work
Improvement should be seen in 2-4 weeks.

Managing side effects
Take with meals to minimize GI irritation. Tablets should be swallowed whole. Do not crush, break, or chew. Avoid driving and other activities requiring alertness. Avoid smoking because nicotine constricts blood vessels. Notify your doctor if nausea, vomiting, GI upset, drowsiness, dizziness, or headache persists because the dosage may need to be reduced.

This information is specific to the use of this medication for HIV-related conditions. For additional information about this drug for other conditions, refer to: www.nursespdr.com/

The drug descriptions on these pages are intended for informational purposes only. The Network does not promote or endorse the use of any specific treatment for any health-related condition. The medications described here can only be dispensed by a licensed health care professional. The information may have changed since these pages were updated, though every effort is made to keep these pages current. Please contact The Network at (800) 734-7104 to make sure you have the most up-to-date information

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