10th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 6-8 November 2008, London, UK

OBJECTIVE AMOUNT OF LIMB FAT IN HIV-INFECTED SUBJECTS WITH SUBJECTIVE DIAGNOSIS OF LIPOATROPHY

Antiviral Therapy 2008; 13(Suppl. 4):A39 (abstract no. P23)

E Martínez¹, M Larrousse¹, D Podzamczer² and JM Gatell^1
1Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain; ²Hospital de Bellvitge, University of Barcelona, L’Hospitalet, Barcelona, Spain

BACKGROUND: The relationship between the subjective diagnosis of lipoatrophy and the objective amount of limb fat loss in HIV-infected adults is unclear.

METHODS: We identified published articles through Medline reporting the amount of arm, leg or limb fat measured by dual X-absorptiometry in HIV-infected patients with moderate– severe lipoatrophy and in healthy non-HIV-infected adults. We calculated the relative content of fat in the limbs, arms and legs of lipoatrophic patients with regard to the weighted arithmetic means of those fat values in healthy controls.

RESULTS: We found 799 patients from 10 articles, and 73 healthy controls from 2 articles. Limb fat ranged from 2.6 to 4.4 kg in patients and from 7.1 to 7.2 kg in controls. Both patients and controls were almost exclusively men, of white race and between 40 and 50 years old. Weighted arithmetic means of arm, leg and limb fat in HIV-infected patients with clinically evident lipoatrophy were 1.0, 2.1 and 3.1 kg (48%, 41%, and 43% of healthy non-HIVinfected males, respectively).

CONCLUSIONS: The diagnosis of lipoatrophy was highly coincidental with the amount of limb fat irrespectively of the investigators. HIV-infected males with clinically evident lipoatrophy had more than 50% of their limb fat lost compared with non-HIV-infected healthy males.

Download PDF of this abstract.

2008-11-06
P23

Copyright © 2008 - International Medical Press Ltd. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Medical Editor, International Medical Press, 36 St Mary-at-Hill, London EC3R 8DU, United Kingdom.