[P-11] SEX DIFFERENCES IN THE CORRELATIONS BETWEEN BASELINE ANTHROPOMETRIC MEASUREMENTS AND FAT DISTRIBUTION IN HIV-INFECTION-ASSOCIATED ADIPOSE REDISTRIBUTION SYNDROME (HARS)

9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV

19-21 July 2007, Sydney, Australia

SEX DIFFERENCES IN THE CORRELATIONS BETWEEN BASELINE ANTHROPOMETRIC MEASUREMENTS AND FAT DISTRIBUTION IN HIV-INFECTION-ASSOCIATED ADIPOSE REDISTRIBUTION SYNDROME (HARS)

Antiviral Therapy 2007; 12(Suppl. 2):L27 (abstract no. P-11)

K Mulligan¹, M Glesby² and E Freedland³
¹University of California, San Francisco, CA, USA; ²Weill Medical College of Cornell University, New York, NY, USA; ³EMD Serono, Rockland, MA, USA, on behalf of the Serostim in HARS Study Group

OBJECTIVES: HARS has been defined as a subset of HIV lipodystrophy with abnormal accumulation of central fat, including visceral fat. Combined baseline data from two clinical trials of patients with HARS were examined to determine whether there were sex-specific differences in the relationship between anthropometric measures and fat distribution.

METHODS: Baseline data from two randomized, double-blind, placebo-controlled studies of recombinant human growth hormone in 561 patients with HARS are included in this analysis. Visceral and subcutaneous adipose tissue (VAT and SAT) were measured by single-slice computed tomography at L4–L5 and trunk fat (TF) by DXA. Data in men and women were compared using the Kruskal–Wallis test; Spearman correlation coefficients were generated for the whole cohort and for each sex.

RESULTS: For the whole cohort, significant correlations (r>0.41) were found between baseline waist circumference (WC), and VAT, SAT and TF (all P<0.001). Correlations were also found between the waist/hip ratio (WHR) and VAT, and VAT/SAT ratio (VSR) (all P<0.001). Women had significantly less VAT, more SAT and TF, and lower VSR than men (all P<0.001). In men, WC correlated (P<0.001) with VAT (r=0.45), SAT (r=0.51), and TF (r=0.69). In contrast, in women, WC was highly correlated with SAT (r=0.78), VSR (r=-0.43) and TF (r=0.89; all P<0.001), but not VAT (r=0.17, P=0.167).

Table 1. (Abstract P-11)

	Men		Women

	Mean baseline		Mean baseline
Parameter	n	measurement (SD)	n	measurement (SD)

WC, cm	482	99.6 (8.1)	79	94.9 (10.7)
WHR	482	1.04 (0.6)	79	0.97 (0.6)
VAT, cm²	411	148.8 (64.9)*,†	67	93.4 (38.4)
SAT, cm²	411	157.2 (94.3)*	67	276.9 (127.7)*
VAT/SAT ratio	411	1.8 (4.1)†	67	0.4 (0.3)*
Trunk fat, kg	464	11.0 (4.6)*,†	75	13.9 (4.9)*

*Significant correlation with WC at baseline (P<0.001); †significant correlation with WHR at baseline (P<0.001).

CONCLUSIONS: These data demonstrate that, in HIV-infected patients with excess central fat, there are sex differences in the distribution of visceral and subcutaneous adipose tissue and their relationships to anthropometric measurements. It remains to be determined whether changes in WC and WHR during treatment correlate with changes in VAT or SAT, and if anthropometric measures could potentially serve as surrogate markers to estimate change in VAT.

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2007-07-24
P-11

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