8th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV San Francisco, California - September 24 - 26, 2006

MECHANISMS OF INSULIN RESISTANCE: LESSONS LEARNED FROM CLINICAL STUDIES

Antiviral Therapy 2006; 11:L2 (abstract no. P4)

KF Petersen
Yale University School of Medicine, New Haven, CT, USA

This plenary session will review the application of magnetic resonance (MR) techniques to examine the pathogenesis of insulin resistance and type 2 diabetes in humans, including: i). Basic principles of MR spectroscopy; ii). ¹³C MR studies to examine the regulation of muscle glycogen synthesis in healthy people and type 2 diabetic patients; iii). ³¹P MR studies to examine the rate controlling steps of insulin stimulated muscle glycogen synthesis in healthy people and type 2 diabetic patients; iv). ¹³C/¹H and ³¹P MR Studies of the mechanism of insulin resistance in: lipodystrophy, normal aging and offspring of diabetic parents; v). the effect of weight loss on hepatic steatosis, hepatic insulin resistance and hyperglycemia in patients with type 2 diabetes.

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2006-09-24
P4

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