3rd International AIDS Society Conference on HIV Pathogenesis and Treatment


Rio de Janeiro - July 24 - 27, 2005

ART IN ORPHANED CHILDREN IN WESTERN KENYA

IAS Conf HIV Pathog Treat 2005 Jul 24-27;3rd: Abstract No. MoPe9.2C11

Nyandiko-Mokaya W.1, Ayaya S.1, Nabakwe E.1, Tenge C.1, Yiannoutsos C.2, Musick B.2
1Moi University, Eldoret, Kenya, 2Indiana University, Indiana, United States of America

INTRODUCTION: We commenced ART in 2002 in MTRH and affliated health centres with the aim of providing comprehensive care to families, including HIV infected orphaned children.

METHODS: Patient care including ART and OI prophylaxis is done according to WHO guidelines by trained doctors and clinical officers.Data is collected into encounter forms at each visit and entered into electronic medical records daily.

RESULTS: We are currently following 1200 HIV exposed and infected children in 2 urban (716) and 7 rural settings (433) of Western Kenya since 2002. 255 of these are on ART, there are 128 girls and 127 boys in the study. The median age of the subjects in the cohort was 5.49 years from newborn (age zero), at the time of study entry, to 15.5 years old. Most were brought in by mothers (51%), 12 % each by father and aunt and 8% by grandparents. 40% of the children are orphaned. 53% were CDC and WHO stages C and III respectively at enrollment, with 75% having immunologic category III. The median CD4 percent was 10% (range 0%-50%) and the weight was 15kg (range 2.3-60.8). Not receiving antiretroviral therapy was associated with almost four times the risk for TB than when receiving antiretroviral therapy (p-value<0.0001). Orphans had a slightly lower CD4 count compared to non-orphaned children (p-value 0.341) Recorded mortatily in these cohort was 7%.

CONCLUSIONS: Many of the children are orphaned. Not being on ART increases the chances of getting TB 4 fold. There is excellent adherence with acceptable response to treatment in orphaned and non-orphaned children. There is a worrying stagnation and subsequent decline of CD4 % at 70 weeks. Being orphaned does not seem to affect adherence as earlier feared. Mortality is not dramatic both in the orphaned and non-orphaned

Acrobat ReaderDownload PDF of this abstract.

050724
Clinical | MoPe9.2C11 | Winstone Nyandiko-Mokaya
9.2 11 9.2 Paediatric treatment strategies

Copyright © 2005 - International AIDS Society (IAS). All information and content relating to the abstracts from the 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment, such as text, graphics, logos, button icons, images, audio clips, and software is protected by copyright. Permission is hereby granted for the non-commercial use or reproduction of the information on this web site, provided that the use of such information is accompanied by an acknowledgement that IAS is the source of the information and the name of the author of the article.

AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, the National Library of Medicine, and donations from users like you. Always watch for outdated information. This article first appeared in 2005. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 2005. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. Permission is hereby granted for the non-commercial use or reproduction of the information herein, provided that the use of such information is accompanied by an acknowledgement that IAS is the source of the information and the name of the author of the article.