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16th International AIDS ConferenceToronto, Canada — August 13-18, 2006 |
Cite as: Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. xx
| Table of Contents Main Monday Tuesday Wednesday Thursday Late-Breakers |
| Wednesday | Oral Abstracts |
| Track A | |
| WeAa01 | Host Factors |
| WeAa0101 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0101 Abstract not available. |
| WeAa0102 | HUMAN TRIPARTITE MOTIF PROTEIN 1 BLOCKS HUMAN IMMUNODEFICIENCY VIRUS REPLICATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0102 Marchant D.1, Neil S.J.D.2, Carter G.2, Harrison I.2, Aubin K.2, Meroni G.3, McKnight Á.2 After fusion with the cell membrane and entry into the cytoplasm, HIV-1 and -2 must therefore avoid host intracellular anti-viral factors including TRIM 1 to complete replication. It will be important to determine the role of these TRIM proteins in the tissue compartmentalisation and pathogenesis of HIV. |
| WeAa0103 | ADVANTAGE OF KIR2DS2 AND HLA-C GROUP C1 IN HIV-1-INFECTED ADOLESCENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0103 Lazaryan A.1, Tang J.2, Wilson C.3, Kaslow R.4 The KIR2DS2 allele and its epistatic interaction with the HLA-C C1 appear advantageous in the immune responses of adolescents to HIV-1 infection. Our findings extend the evidence for a role of NK receptors in the pathogenesis of HIV/AIDS. |
| WeAa0104 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0104 Abstract not available. |
| WeAa0105 | PROTHYMOSIN ALPHA A NOVEL ANTIVIRAL RESTRICTION FACTOR THAT BLOCKS TRANSCRIPTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0105 Mosoian A.1, Teixeira A.1, High A.A.2, Hunt D.F.2, Shabanowitz J.2, Liu X.1, Klotman M.E.1 ProTa suppresses HIV-1 gene transcription in primary macrophages and dendritic cells and contributes to the anti-viral activity of CD8+ cell supernatant. |
| WeAa0106 | GLOBOTRIAOSYLCERAMIDE: A NATURAL RESISTANCE FACTOR TO HIV INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0106 Lund N.1, Sakac D.2, Lingwood C.A.3, Levene C.4, Hellberg Å.5, Olsson M.L.5, Branch D.R.2 Overall, HIV infection is inhibited when Gb3 is cell surface expressed, while its absence enhances infection. Furthermore, exogenously introduced Gb3 seems to mimic natural Gb3 over-expression (P1k). These findings support Gb3 as providing natural resistance to HIV-1. |
| WeAa02 | Effectiveness of Anti-HIV T Cell Immunity |
| WeAa0201 | DESIGNING A VACCINE STRATEGY: IMPLICATIONS OF VIRAL ESCAPE AND SHIV-SPECIFIC CD8 T CELLS AT TRANSMISSION AND DURING ACUTE INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0201 Fernandez C.S.1, Smith M.Z.1, Batten C.J.1, De Rose R.1, Reece J.1, Rollman E.1, Venturi V.2, Davenport M.P.2, Kent S.J.1 Effector T cells present at transmission and capable of rapid expansion are vital for the prevention of reversion to wild-type and control of HIV/SHIV viremia. |
| WeAa0202 | INCORPORATION OF SEQUENCE DIVERSITY INCREASES THE RATE OF DETECTION OF HIV-SPECIFIC T CELL RESPONSES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0202 Frahm N.1, Yusim K.2, Fisher W.2, Muldoon M.3, Linde C.1, Hewitt H.1, Faircloth K.1, Walker B.1, Brander C.1, Korber B.2 The data thus show that toggled peptides represent a powerful tool for the detection of more comprehensive breadth and magnitude of T cell responses, therefore providing additional insight as to which regions of HIV are targets of the virus-specific cellular immune responses, and hence may reflect potential vaccine candidates. |
| WeAa0203 | DUAL SELECTION PRESSURE BY DRUGS AND HLA CLASS I-RESTRICTED IMMUNE RESPONSES ON HIV-1 PROTEASE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0203 Mueller S.M.1, Schaetz B.1, Eismann K.1, Bergmann S.1, Bauerle M.1, Schmitt-Haendle M.1, Maurer K.1, Schmucker M.2, Walter H.3, Schmidt B.3, Korn K.3, Sticht H.4, Spriewald B.5, Harrer E.G.1, Harrer T.1, HIV Competence Network HIV/AIDS Our results support a fundamental role of HLA class I-restricted immune responses in shaping the sequence of the HIV-1 protease in vivo. This may have important clinical implications both for to the understanding of drug resistance pathways and for the design of therapeutic vaccine. |
| WeAa0204 | VACCINE INDUCED T-CELL RESPONSES IN IMMUNISED RHESUS MACAQUES CORRELATE WITH SIV REPLICATION KINETICS IN VITRO BUT NOT IN VIVO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0204 Ochieng' W., Stahl-Hennig C., Suh Y.-S., Sopper S., Hunsmann G., Sauermann U. SIV replication in vitro correlates with vaccine-induced T cell responses and shows "immunisation-route-dependent" kinetics. This kinetics was predictive of post-challenge outcome and may be useful in designing pre-clinical vaccine and pathogenesis studies. Additional factors worth investigation may influence in vitro vaccine response. |
| WeAa0205 | CROSS-CLADE RECOGNITION OF GAG-P24 GPSHKARVL EPITOPE RESTRICTED BY HLA-B7 IN A HIV-1 CRF15-01B INFECTED INDIVIDUAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0205 Castro E.1, Harari A.1, Cellerai C.1, Bart P.A.1, Chave J.P.2, Pantaleo G.1 We provide evidence that Gag-p24 sequence "GPSHKARVL" is a viral conserved motif and CTL epitope in a patient with a CRF15-01B infection. The fact that this epitope has been previously reported among other HLA-B7 individuals infected with clades C and B underlines its relevance for vaccine trial monitoring. |
| WeAa03 | Mucosal and Innate Immunity |
| WeAa0301 | DIFFERENTIAL CYTOKINE RESPONSIVENESS TO TOLL-LIKE RECEPTOR (TLR) LIGAND STIMULATION IN HIV-1 RESISTANT SEX WORKERS FROM NAIROBI, KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0301 Ball T.B.1, Lester R.1, Wachihi C.2, Marlin C.1, Plummer F.1, HayGlass K.3 Resistant women have significantly altered innate responses to some TLR ligands compared to uninfected controls, which may reflect their ability to mount a protective adaptive response to HIV-1. Interestingly cytokines known to induce cellular immunity were depressed while these women had elevated immunosuppressive cytokine responses. HIV resistance may therefore be associated with a hyporesponsive innate response rather than a preference to generate cellular immune responses. |
| WeAa0302 | TREG CHARACTERIZATION IN SIV INFECTION OF RHESUS MACAQUES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0302 Barbercheck J.1, Apetrei C.2, Ploquin M.3, Butor C.4, Muller-Trutwin M.3, Veazey R.1, Lackner A.5, Pandrea I.1 Our study demonstrates that these species are good models for studying Tregs' role in HIV infection. Tregs' decrease during SIVmac infection may result in lack of immuneoregulation and aberrant hyperactivation of T cells. The role of Tregs in pathogenicity can only be determined using animal models. |
| WeAa0303 | MULTIPLE NEWLY IDENTIFIED URIDINE-RICH TLR7/8 LIGANDS WITHIN THE RNA OF HIV-1 ACTIVATE HUMAN CD8+ T CELLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0303 Meier A., Alter G., Streeck H., Teigen N., Altfeld M. These data demonstrate that uridine-rich regions of the ssRNA of HIV-1 can serve as potent immune-modulators and induce immune activation of T cells through the ligation of TLR7/8. HIV-1-derived TLR ligands may therefore contribute to the chronic immune activation observed during viremic HIV-1 infection, as well as to the associated immune pathogenesis and disease progression. |
| WeAa0304 | POTENTIAL MUCOSAL IMMUNE MECHANISMS FOR INCREASED HIV SUSCEPTIBILITY IN WOMEN INFECTED BY HERPES SIMPLEX TYPE 2 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0304 Rebbapragada A.1, Pettengell C.1, Sunderji S.1, Huibner S.1, Sheung A.1, Moussa G.2, Mazzuli A.2, Wachihi C.3, Jaoko W.4, Ball B.5, Fowke K.5, Plummer F.5, Kaul R.1 DC-SIGN, which has been hypothesized to act as a "Trojan horse" in transporting HIV virions from mucosal sites to lymph nodes, was significantly increased in the FGT of women with chronic HSV2 infection. This suggests a potential immune mechanism for enhanced HIV susceptibility. HSV2 shedding was infrequent in HIV uninfected FSWs, and TLR9 induction may be associated with local control of HSV2 reactivation. |
| WeAa0305 | TRANSCYTOSIS OF HIV ACROSS POLARIZED ORAL EPITHELIAL CELLS REDUCES INFECTIOUS ACTIVITY OF HIV-1 VIRIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0305 Tugizov S.1, Herrera R.1, Levy J.1, Martinez-Marino B.2, Abreu M.1, Soros V.3, Greene W.3, Palefsky J.1 Cell-free and cell-associated HIV migrate across polarized oral epithelial cells by apical-to-basolateral transcytosis. Compared with virions transcytosed across endometrial cells, virions transcytosed across tongue and pharyngeal cells lost most of their infectious activity. Inactivation of HIV during transcytosis across oral epithelial cells might contribute to the low rate of oral HIV transmission. |
| WeAa04 | T Cell Immunity to HIV in Acute/Chronic Infection |
| WeAa0401 | LONG-TERM NONPROGRESSOR'S JOURNEY INTO PROGRESSIVE DISEASE: ASSOCIATION WITH ESCAPE FROM CELLULAR IMMUNE CONTROL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0401 Kemal K.1, Beattie T.2, Dong T.2, Weiser B.1, Kuiken C.3, Sutton J.2, Lang D.3, Yang H.2, Yang P.2, Collman R.4, Philpott S.1, Rowland-Jones S.2, Burger H.1 This man's journey from LTNP to progressive infection was associated with both the acquisition of viral mutations conferring escape from CD8 mediated control and targeted depletion of HIV-1-specific CD4+ T cells. These data are relevant to the correlates of protection from disease progression. |
| WeAa0402 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0402 Abstract not available. |
| WeAa0403 | SURVEILLANCE OF IL-2 INDUCING CD4+ T CELL EPITOPES IN ACUTE HIV-1 INFECTION FOR THE EMERGENCE OF ESCAPE MUTANTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0403 Jones R.B.1, Yue F.Y.1, Kovacs C.M.2, Mohamed R.1, MacDonald K.S.1, Ostrowski M.A.1 This is the first study to characterize IL-2 inducing epitopes during acute HIV-1 infection, and their contemporaneous plasma viruses. The data support that selective pressure exerted by the CD4 immune response contributes to virus variation. However, the progressive loss of HIV-1 p55 specific IL-2 producing CD4 T cells could not be attributed solely to viral evasion of immune responses through the fixation of escape mutations within targeted epitopes. Examining the responses of these clones to autologous p55 variants, from both early and late stages of infection, will shed further light on whether the observed flanking mutations represent a means of escape from immunological pressure. |
| WeAa0404 | T CELL RESPONSES TO HUMAN ENDOGENOUS RETROVIRUSES IN PRIMARY HIV INFECTION: A NOVEL VACCINE STRATEGY? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0404 Garrison K.1, Jones R.B.2, Meiklejohn D.A.1, Agrawal A.1, Anwar N.2, Spotts G.3, Hecht F.M.3, Rakoff-Nahoum S.4, Lenz J.5, Ostrowski M.A.2, Nixon D.F.1 |
| WeAa0405 | HIV-SPECIFIC IFN- AND IL-2 SECRETING RESPONSES AND THEIR ASSOCIATION TO HLA ALLELES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0405 Peretz Y.1, Ndongala L.M.1, Boulassel R.2, Routy J.-P.2, Sékaly R.-P.3, Tremblay C.L.3, Tsoukas C.M.4, Bernard N.F.1 Responses restricted to slow progressing alleles such as B27 and B57 are more likely to stimulate IFN-γ and IL-2 secretion, a functional profile that is associated with viral control. |
| WeAa0406 | COMPARATIVE VIRAL FITNESS ASSESSMENT OF CONGENIC MUTATIONS WITHIN AN IMMUNODOMINANT CD8+ T CELL EPITOPE OF HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0406 Christie N.1, Willer D.O.2, Lobritz M.3, Cochrane A.4, Luscher M.A.2, Arts E.J.3, MacDonald K.S.5 Mono- and dual infection assays indicate that the emergence of potential immune escape mutations are limited by factors other that purely viral fitness constraints. This suggests that a lack of emergence of CTL escape mutations may not always be indicative of restrictions in viral replication. In fact, the conservation of these epitopes may be a feature of a crippled immune response, incapable of placing pressure on the viral sequence. |
| Track B | |
| WeAa05 | Microbicide Development |
 WeAa0501 |
Invited Presentation: Overview of Microbicide Development Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0501 Robin Shattock This is a Power Point presentation. There is no abstract available. |
| WeAa0502 | CONTRACEPTIVE AND NON-CONTRACEPTIVE THIOUREA NON-NUCLEOSIDE INHIBITOR-BASED ANTI-HIV MICROBICIDES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0502 D'Cruz O.1, Uckun F.2 Membrane-permeable tight-binding thiourea NNRTIs have particular clinical utility as spermicidal or non-spermicidal broad-spectrum anti-HIV-1 microbicides as well as prophylactic antiviral agents. Supported by: NIH grants AI052594, AI052633, AI054352 and HD043683. |
| WeAa0503 | CHARACTERIZATION OF IN VITRO RELEASE AND IN VIVO DELIVERY OF TMC120 WITH AN INTRAVAGINAL RING: IMPLICATIONS FOR MICROBICIDE DELIVERY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0503 Romano J.1, Coplan P.1, Mitchnick M.1, Douville K.1, Malcolm K.2, Van Roey J.3, Temmerman M.4, Van Bortel L.4, Weyers S.4, Rosenberg Z.1 The study demonstrated that IVR delivery of TMC120 was safe and generally well tolerated, and release of drug in vivo could be achieved. |
| WeAa0504 | TRAPPIN-2: DISCOVERY OF A NOVEL INHIBITOR OF HIV HIGHLY ELEVATED IN HIV-RESISTANT SEX WORKERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0504 Iqbal S.1, Ball T.1, Ao Z.1, Maranan L.1, Rutherford J.1, Wachihi C.2, Pak B.3, Podust V.3, Yao X.-J.1, Plummer F.1 We have identified a previously uncharacterized inhibitor of HIV using a novel proteomics approach. Importantly, elevated expression of this protein is highly associated with natural immunity to HIV infection in a HIV-resistance cohort. As such, this protein may make an ideal candidate for a component of a preventative microbicide. |
| WeAa0505 | PRECLINICAL ASSESSMENT OF TOPICAL MICROBICIDES: DEVELOPMENT OF A MICROBICIDE QUALITY ASSURANCE PROGRAM (MQAP) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAa0505 Cummins J.1, Lackman-Smith C.1, Richardson-Harman N.2, Beer B.1, Reichelderfer P.3 Given the wide range of existing and novel assay methods, there is a need to maintain a quality control program for topical microbicides. By establishing standardized guidelines for preclinical testing and analysis, the MQAP will expedite advancement of microbicides through the drug development pipeline. |
| Track B | |
| WeAb01 | Delivering HAART in Women Following Delivery |
| WeAb0101 | LOW SENSITIVITY OF TOTAL LYMPHOCYTE COUNT, AS A SURROGATE MARKER TO IDENTIFY PRE- AND POST-PARTUM INDIAN WOMEN WHO REQUIRE ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0101 Gupta A.1, Gupte N.2, Nayak U.3, Kulkarni V.2, Paranjape R.4, Thakar M.4, Sastry J.2, Phadke M.5, Bollinger R.1, MIT-BJMC-JHU Study Group Our data suggests that pre-partum and PP women with TLC <1200 cells/mm3 are likely to have CD4 cell counts <200. However, the sensitivity of this TLC cut-off was low. Between 45 – 64% of pre-partum and PP women requiring initiation of ART may not be identified by using TLC alone as a surrogate marker for CD4<200. The UNAIDS recommended TLC cutoff of <1200 cells/mm3 is not optimal for this female population. |
| WeAb0102 | 24 MONTH OUTCOME OF NEVIRAPINE BASED HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) IN WOMEN DURING THE POSTPARTUM PERIOD: A PMTCT+ PILOT PROGRAM SUPPORTED BY THE GLOBAL FUND IN THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0102 Jourdain G.1, Briand N.2, Fregonese F.3, Halue G.4, Chutanunta A.5, Nilmanat A.6, Prommas S.7, Bowonwatanuwong C.8, Yuthavisuthi P.9, Lallemant M.10, Program for HIV Prevention and Treatment (PHPT) - IRD 174 The good response to triple therapy would not have been observed without optimal adherence. If international efforts had not facilitated access to efficacious combinations, it is likely that patients would have use affordable but suboptimal combinations, increasing the risk of spreading resistance mutations in the population. |
| WeAb0103 | DEVELOPMENT OF ANTIRETROVIRAL RESISTANCE AMONG HIV-1-INFECTED WOMEN FIRST EXPOSED TO ANTIRETROVIRALS DURING PREGNANCY: THE NICHD INTERNATIONAL SITE DEVELOPMENT INITIATIVE (NISDI) PERINATAL STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0103 Duran A.1, Losso M.1, Salomón H.2, Pampuro S.2, Harris R.3, Soto-Ramirez L.4, Read J.5, NISDI Perinatal Study Group Among HIV-1-infected mothers from Latin American and Caribbean countries receiving ARVs for prevention of MTCT, PRMs are relatively common. |
| WeAb0104 | MATERNAL IMMUNE RESPONSE AND CLINICAL OUTCOMES ON NNRTI-BASED ANTIRETROVIRAL THERAPY (ART) FOLLOWING EXPOSURE TO SINGLE-DOSE NEVIRAPINE (NVP) FOR PREVENTION OF MOTHER-TO-CHILD HIV TRANSMISSION (PMTCT) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0104 Chi B.1, Sinkala M.2, Levy J.1, Cantrell R.1, Stringer E.1, Bulterys M.3, Zulu I.4, Kaseba C.4, Mtonga V.5, Wilfert C.6, Stringer J.1 In this large programmatic ART cohort in Zambia, exposure to NVP for PMTCT was not associated with attenuated maternal immune response or worse clinical outcomes overall. Further studies are needed to determine the potential impact on treatment failure of timing between NVP exposure and ART initiation, particularly among women reporting recent NVP use. |
| WeAb0105 | HIGH RATE OF NELFINAVIR-ASSOCIATED MUTATIONS OBSERVED AMONG WOMEN EXPOSED TO PROPHYLACTIC ANTIRETROVIRAL DURING PREGNANCY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0105 Kakehasi F.M., Tupinanmbas U., Cleto S., Aleixo A., Lin E., Melo V., Aguiar R., Pinto J., Maternal and Pediatric AIDS Group In this group of women ART regimens were very efficient to block MTCT, despite the partial virologic suppression. The finding of a high rate of nelfinavir resistant mutation observed in the post-partum period may impact future therapeutic options for these women. |
| WeAb02 | STIs: Is it Smart to Stop HAART? |
| WeAb0201 | PLASMA LEVELS OF NEVIRAPINE FOLLOWING INTERRUPTION OF ZDV/3TC/NVP IN AFRICAN ADULTS WITHIN THE DART TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0201 Kikaire B.1, Walker S.2, Khoo S.3, Munderi P.1, Ssali F.4, Namale L.4, Reid A.5, Gibb D.2, Mugyenyi P.4, Grosskurth H.1 Plasma NVP levels are below the subtherapeutic range after one week, and below the limit of quantitation after two weeks, in the majority of patients investigated. These data support the use of a one-week dual nucleoside 'cover' for planned treatment interruptions with NVP. |
| WeAb0202 | CD4-GUIDED STI: FOUR-YEARS FOLLOW-UP OF A CONTROLLED, PROSPECTIVE TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0202 Maggiolo F.1, Ripamonti D.1, Callegaro A.2, Gregis G.1, Quinzan G.1, Airoldi M.1, Bombana E.1, Arici C.1, Suter F.1 CD4-guided pulse-therapy is as least as effective as continuous HAART from the immunologic, virologic and clinical standpoints and is generally safe if patients are properly monitored. A nadir CD4 cell count <350 cell/mcL is the main predictor of CD4 cell decline and of the possibility to stay off-therapy. These findings should be considered in designing STI programs, but also outline possible risks of a late start of HAART. |
| WeAb0203 | PROGRESSION OF HIV-RELATED DISEASE OR DEATH (POD) IN THE RANDOMISED SMART STUDY: WHY WAS THE RISK OF POD GREATER IN THE CD4-GUIDED ((RE)-INITIATE ART AT CD4 <250 CELLS/μL) DRUG CONSERVATION (DC) VS THE VIROLOGICAL SUPPRESSION (VS) ARM? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0203 Lundgren J.D., on behalf of the SMART Study Group Intended differences in proximal CD4 and VL levels between the arms of the study explains a substantial part of the difference in the risk of POD between the DC and VS arms. Additional analyses on predictors of POD will be presented. |
| WeAb0204 | INFERIOR CLINICAL OUTCOMES WITH EPISODIC CD4-GUIDED ANTIRETROVIRAL THERAPY AIMED AT DRUG CONSERVATION (DC) IN SMART STUDY: CONSISTENCY OF FINDING IN ALL PATIENT SUBGROUPS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0204 El-Sadr W., for the SMART Study Group HR for DC/VS groups for POD was consistent in a number of subgroups with no patient subgroup having lower POD rate in DC arm. Patients with HIV RNA <400 copies/ml (on ART at Entry) had significantly higher HR estimates (DC/VS), as this subgroup of patients had low POD rates in VS arm. Episodic ART as per SMART design is inferior to VS across a number of a priori defined subgroups. |
| WeAb0205 | TIME TO HAART RESUME AFTER STRUCTURED TREATMENT INTERRUPTION IS STRONGLY ASSOCIATED WITH HIV DNA LEVEL IN PBMC AT INTERRUPTION: RESULTS OF THE ANRS 116 SALTO TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0205 Piketty C.1, Weiss L.1, Bachir-Cherif S.2, Assoumou L.2, Burgard M.3, Ragnaud J.-M.4, Bentata M.5, Girard P.-M.6, Rouzioux C.3, Costagliola D.2, The ANRS 116 SALTO study group Long term treatment interruption is feasible in patients who started HAART based on earlier guidelines. HIV-DNA level may be a useful tool to select patients who may benefit of a prolonged treatment interruption. |
| WeAb03 | Optimizing HAART for Children |
| WeAb0301 | EFFICACY AND SAFETY RESULTS OF 48 WEEKS OF TREATMENT WITH APTIVUS ORAL SOLUTION CO-ADMINISTERED WITH LOW DOSE RITONAVIR (APTIVUS/R) IN CHILDREN AND TEENAGERS (PHASE I/IIA STUDY) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0301 Salazar J.1, Cahn P.2, Della Negra M.3, Castelli-Gattinara G.4, Fortuny C.5, Flynn P.6, Giaquinto C.7, Yogev R.8, Caparelli E.9, Fenton T.10, Mikl J.11, Jelaska A.11, PACTG 1051 Clinically relevant virological and immunological improvements were seen with APTIVUS/r therapy in treatment experienced children aged 2 – 18 years at Week 48. APTIVUS/r provides a potent and well-tolerated therapeutic option for children and teenagers. |
| WeAb0302 | 3TC +ABC MAINTAINS VIROLOGICAL SUPERIORITY OVER ZDV+3TC AND ZDV+ABC BEYOND 5 YEARS IN CHILDREN: THE PENTA 5 TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0302 Gibb D.M.1, Green H.1, Saidi Y.2, Pillay D.3, Compagnucci A.2, Harper L.1, Walker A.S.1, Castelli-Gattinara G.4, della Negra M.5, Levy J.6, Candeias F.7, Butler K.8, Feiterna-Sperling C.9, Wintergerst U.10, Giaquinto C.11, on behalf of PENTA 5 Improved efficacy, in terms of VL suppression and growth changes, and lower rates of switching with detectable VL in the 3TC +ABC arm were sustained through to year 5. |
| WeAb0303 | LONG-TERM EFFECTIVENESS OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON THE SURVIVAL OF CHILDREN AND ADOLESCENTS INFECTED WITH HIV-1 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0303 Patel K.1, Hernán M.A.1, Williams P.L.2, Seeger J.D.1, McIntosh K.3, Seage III G.R.1, for the Pediatric AIDS Clinical Trials Group 219/219C Study Team The use of HAART is highly effective in reducing mortality among children and adolescents infected with HIV. Effects of HAART on survival, appropriately controlling for confounding by severity, are consistent with those observed in adult trials. |
| WeAb0304 | COMPARATIVE BIOAVAILABILITY STUDY OF A NOVEL PEDIATRIC FIXED DOSE DISPERSIBLE TABLET (FDDT) OF LAMIVUDINE, STAVUDINE AND NEVIRAPINE VERSUS INDIVIDUAL MARKETED LIQUID FORMULATIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0304 Shankar G.1, Manaktala C.1, Verma M.1, Chhabra A.2, Juneja S.2 It was concluded that the FDDT of lamivudine, stavudine and nevirapine could be used in place of individual liquid formulations. This would enhance convenience of administration and compliance with therapy. |
| WeAb0305 | NEVIRAPINE CONCENTRATIONS IN HIV-INFECTED CHILDREN TREATED WITH DIVIDED FIXED DOSE COMBINATION TABLETS IN MALAWI AND ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAb0305 Mulenga V.1, Ellis J.2, Ewings F.3, L'homme R.4, Chintu C.1, van Oosterhout J.5, Chileshe R.1, Molyneux E.2, Gibb D.3, Burger D.4 To avoid nevirapine underdosing in young children, divided FDC triomune should be used with caution; nevirapine levels may be reduced in stunted but increased in wasted children. Further studies investigating these relationships are required. |
| Track C | |
| WeAc01 | Thinking Positive: The Role of People Living with HIV in Prevention Initiatives |
| WeAc0101 | UNSAFE SEX IN STEADY PARTNERSHIP AMONG HIV-INFECTED PATIENTS: EVIDENCE FROM A LARGE REPRESENTATIVE SAMPLE OF OUTPATIENTS ATTENDING FRENCH HOSPITALS (VESPA/ANRS 2003) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0101 Bouhnik A.-D.1, Préau M.1, Schiltz M.-A.2, Obadia Y.1, Lert F.3, Spire B.1, VESPA study group A high number of serodifferent couples persist in reporting risky sexual behaviour. Patients' personal experience and HIV disclosure represent key factors on the path to adopting safer sex among homosexuals. Among heterosexuals, socio-economic conditions play a major role in risk-taking. |
| WeAc0102 | EXPERIENCES OF PEOPLE LIVING WITH AIDS (PLWA) FOLLOWING ENROLLMENT IN THE BOTSWANA NATIONAL TREATMENT PROGRAMME (BNTP) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0102 Percy-de Korte F.1, Weiser S.1, Leiter K.1, de Korte D.1, Wolfe W.1, Phaladze N.2, Iacopino V.1, Heisler M.3 Sexual behaviour change facilitating HIV prevention was reported, in association with increasing comfort in disclosing sero-status. These findings are contrary to studies in developed countries, reporting re-uptake of risky sexual behaviour among men having sex with men receiving ART. Results indicate the importance of including PLWA enrolled in treatment programmes as agents of behaviour change in high prevalence countries. Policies and programmes which involve PLWA can facilitate HIV testing, treatment uptake, disclosure, subsequent enrollment of others, and show promise in changing sexual behaviour for reduced HIV transmission. |
| WeAc0103 | KNOWLEDGE OF HIV POSITIVE STATUS DECREASES PREGNANCY INTENTION AND INCREASES CONTRACEPTIVE USE AMONG WOMAN IN LILONGWE, MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0103 Hoffman I.1, Chanza H.2, Martinson F.2, Chilongozi D.2, Powers K.1, Hosseinipour M.2, Dziza E.2, Kachipa E.2, Mphande C.2, Nkhalamba T.2, Stephenson R.3, Tsui A.4 There was a significant reduction in women wanting pregnancy after being notified of their positive HIV status, and an accompanying increase in the use of contraceptives. Condom use among these HIV+ women was disturbingly low. Despite counseling and the availability of contraceptive services, incidence of pregnancy was high, even among women reporting they did not want another child. Immune status affects both pregnancy intention and contraceptive use. Culturally sensitive programs that assist HIV+ women in making sound reproductive choices are urgently needed. |
| WeAc0104 | PREVENTION WITH POSITIVES PROGRAMS IN CLINICAL CARE SETTINGS IN THE UNITED STATES: RECEIPT OF PREVENTION COUNSELING AND CARE SATISFACTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0104 Patel S.N.1, Golin C.E.2, Lu T.-S.3, Tien H.3, Thompson M.4, Thrun M.5, Wilson T.6, Timmons A.6, Yale A.5, Clemons J.4, Quinlivan E.B.7, Wright J.8 People living with HIV (HIV) reported increases in provider-delivered risk reduction counseling and satisfaction with care after 6 months. Although we cannot stratify yet by dose of provider intervention received, 12 month follow-up and dose collection are underway and may strengthen our conclusions. |
| WeAc0105 | EXPERIENCE OF THE RUSSIAN RED CROSS IN PROVIDING MEDICAL AND PSYCHOLOGICAL ASSISTANCE TO HIV+ WOMEN AND CHILDREN BORN TO HIV+ MOTHERS IN IRKUTSK CITY (EAST SIBERIA), RUSSIAN FEDERATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0105 Zagainova A.1, Shishkina V.2 The experience of the C&S Project and the visiting nurse service in Irkutsk has been a unique and successful model of collaboration between federal institutions and NGOs such as the RRC. This collaboration has helped create a system of advocacy and integrated services (care & prevention) for HIV+ women and HIV+ children. With continued support and funding from Federal health authorities, this model can be replicated in other RRC branches in Russia. |
| WeAc02 | What's New? Innovations in HIV Prevention |
| WeAc0201 | REACHING OUT TO CSWS THROUGH A CARE AND SUPPORT PROGRAMME FOR OVC Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0201 Singh V.1, Chhakchhuak L.2 Care and support for children infected and/or affected by HIV/AIDS is effective for engage CSWs and drug users in preventive programs, especially in difficult social circumstances. Advocacy with communities helps reduce stigma and discrimination - a key for effective HIV/AIDS prevention programs. |
| WeAc0202 | BASELINE STUDY INFORMS ESTABLISHMENT OF A MOBILE UNIT PROVIDING HIV/AIDS/STI INFORMATION, SKILLS AND SERVICES TO VULNERABLE ADOLESCENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0202 Campbell P.1, Bell R.2 Rich, detailed findings disaggregated by age, gender and location were provided, enabling the service to be tailored to address specific vulnerabiliities. The service's mobility was strongly endorsed because staff "not from area". |
| WeAc0203 | RANDOMIZED CONTROLLED TRIAL OF AN HIV RISK-REDUCTION INTERVENTION FOR DEPRESSED AFRICAN AMERICAN ADOLESCENTS: A SUBSET ANALYSIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0203 DiClemente R., Wingood G., Lang D. This is the first study to demonstrate a significant intervention effect for depressed adolescents. Given the high prevalence of depression among this population, the intervention could have a substantial impact in reducing adolescents' vulnerability for HIV infection. |
| WeAc0204 | INVOLVING MEN IN PREVENTION AND CARE - CRUCIAL INTERVENTION FOR REDUCTION OF HIV/AIDS MORBIDITY AND MORTALITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0204 Byakatonda J.1, Kerressey M.2 Creative programmes tailored towards constructive involvement of men and designed to reduce gender inequalities and minimize the impact of HIV/AIDS is needed. Sensitization on risks of contracting HIV/AIDS within marriage with peer support in couple clubs is important prevention strategies, decreasing not only HIV/AIDS morbidity but also supporting healthier family lives. |
| WeAc0205 | HOW TO TRAIN HEALTH PROVIDERS TO TALK ABOUT SEXUAL PLEASURE: EXPERIENCES FROM CAMBODIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0205 Gordon P.1, Chi S.2, Philpott A.1 With support, sexual health trainers can be enabled to discuss sex and pleasure as a way of promoting safer sex. By the end of the training, almost without exception, participants expressed a commitment to extending this discussion to their own practice. As a result of the training, the Pleasure Project is designing a "sexy sexual health toolkit" as an education/training resource to help sex educators promote safer sex in a sex-positive way in their own projects. |
| WeAc03 | Global Trends in HIV Risk Behaviours |
| WeAc0301 | TRENDS IN CONDOM USE IN LAST SEX AMONG YOUNG SINGLE AFRICAN WOMEN, 1996 – 2002 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0301 Ali M.M.1, Cleland J.2 Condom promotion in Africa has had an impact on the behaviour of young single women and the pace of change compares favourably with changes in other behaviour that harms health, such as cigarette smoking. However, sharp socio-economic disparities in use are apparent that may reflect differential access. A greater emphasis on condom promotion for pregnancy-prevention is justified because it must be more feasible for a young woman to negotiate use for this purpose than for disease-prevention. |
| WeAc0302 | A LONGITUDINAL ASSESSMENT OF HIV/AIDS KNOWLEDGE, RISK, AND BEHAVIOR IN CAMBODIA (2003 – 2005) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0302 Keo P.1, Cheaty L.1, Khim V.1, Chann B.2, O'Connell K.1 Messages should continue to stress the importance of consistent condom use and communicate that all partners pose a risk for HIV/AIDS. Campaigns should continue to reduce stigma related to condom use and foster social support by promoting it as appropriate with all partners, even trusted partners. |
| WeAc0303 | TRENDS IN HIV-RELATED RISK BEHAVIORS AMONG US ADOLESCENTS: 15 YEARS OF PROGRESS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0303 Kann L., Lowry R., Eaton D., Wechsler H. While HIV-related risk behaviors have decreased steadily overall, some subgroups of high school students in the United States may be at increased risk. |
| WeAc0304 | HIV EPIDEMIC STATUS AND BEHAVIORAL SURVEILLANCE AMONG MSM IN CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0304 Xu H.1, Zhang B.2, Zeng Y.3, Li X.2 Though HIV prevalence was relative low in Chinese MSMs, however high-risk sexual behaviors still existed in MSMs. They often practiced unsafe sex. Once HIV enters the MSM population in some cities, it will quickly spread in this group. In addition, MSMs often had sex with females. Virus can transmit between MSMs and prostitutes, then transmit to to general population. Urgent harm reduction program and health education program should be implemented to reduce the epidemic risk of HIV among MSMs. |
| WeAc0305 | SEX WORK TYPOLOGY AND RISK FOR HIV IN FEMALE SEX WORKERS (FSWS): FINDINGS FROM AN INTEGRATED BIOLOGICAL AND BEHAVIOURAL ASSESSMENT IN THE SOUTHERN INDIAN STATE OF KARNATAKA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAc0305 Ramesh B.1, Washington R.2, Mondal S.3, Moses S.4, Alary M.5, Blanchard J.F.6 HIV risk among FSWs varies considerably by type of sex work. Preventive interventions for these highly vulnerable individuals must incorporate this information into their designs. |
| Track D | |
| WeAd01 | Economic exclusion, racism and vulnerability |
| WeAd0101 | WHAT WILL HAPPEN WHEN GRANDMOTHERS DIE? UNPACKING THE GENDER AND GENERATIONAL IMPLICATIONS OF AIDS AND HOUSEHOLD CHANGES AMONG STREET TRADERS IN DURBAN, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0101 Chazan M. Older women in this study are unevenly and increasingly burdened by AIDS. As prevalence and unemployment levels rise, they assume ever greater financial and care-taking responsibilities in their families; they are also displaced and chronically ill. Yet, the phenomenon of households pivoting around grandmothers is not new in southern Africa. What is new is AIDS: combining national data with detailed ethnography, this analysis raises questions about what will happen when today's grandmothers die and suggests that the "next generation" of grandmothers may be disappearing. Together, understanding the country's changing demographics, street traders' household dynamics, and older women's vulnerabilities provides key insights into the gender and generational implications of AIDS in this context of rapid urbanization and political-economic change. |
| WeAd0102 | RACISM AND HIV/AIDS: IMPACTS OF RACIALIZED DISCOURSE ON THE DAILY LIVES OF AFRICAN AND CARIBBEAN COMMUNITIES IN TORONTO, CANADA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0102 Gardezi F.1, Calzavara L.1, Lawson E.1, Husbands W.2, Tharao E.3, Willms D.4, George C.5, Myers T.1, Remis R.S.6, Taylor D.7, Adebajo S.1, McGee F.8, Wambayi E.J.9 Representation and discourse around race and HIV/AIDS filters into the daily lives of African and Caribbean people, and resonates with experiences of racism, colonialism and lack of access to resources. Education, policy and institutional practices responding to HIV cannot neglect the ways in which they may perpetuate systems of inequality, furthering HIV stigma. Institutional practices and policies need to be informed by the lived experiences of African and Caribbean people and their critiques of dominant discourses. |
| WeAd0103 | HIV VACCINE CONCERNS AND MISTRUST AMONG VULNERABLE COMMUNITIES: TOWARDS PROACTIVE, CULTURALLY-APPROPRIATE INTERVENTIONS (PROJECT VIBE) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0103 Newman P.A.1, Cunningham W.E.2, Lee S.-J.3, Seiden D.3, Duan N.3 Widespread HIV vaccine concerns, misconceptions and mistrust among vulnerable communities present formidable challenges to HIV vaccine dissemination, and may thereby compromise the effectiveness of vaccines in controlling the AIDS pandemic. Culturally-appropriate, empirically-based individual- and community-level interventions are essential to address HIV vaccine concerns and mistrust before an approved vaccine becomes pubicly available. |
| WeAd0104 | DETERMINANTS OF HIV-RISK BEHAVIOR IN REFUGEES FROM AFRICA RESIDING IN SWEDEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0104 Steel J.1, Dunlavy A.2, Herlitz C.3, Theorell T.4 HIV/AIDS prevention interventions should be culturally sensitive and address specific determinants of risk behavior of that population. |
| WeAd0105 | THE CHALLENGE OF PROVIDING ADEQUATE INFANT NUTRITION FOLLOWING EARLY BREASTFEEDING CESSATION BY HIV-POSITIVE, FOOD-INSECURE MOZAMBICAN MOTHERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0105 Johnson W.1, Alons C.2, Fidalgo L.3, Piwoz E.4, Kahn S.5, Macombe A.6, Catarina R.7, Briend A.8, Lovich R.9, Warming E.10, Floriano F.1, Chavane V.10 EBC is likely to increase the risk of malnutrition among already vulnerable infants from food insecure families. Specialized replacement foods and/or increased access to maternal ARV treatment are needed to protect child health and survival in areas affected by chronic and seasonal food shortages. |
| WeAd02 | Young People and Sexuality: The Unspoken and the Taboo |
| WeAd0201 | SURVEY OF CHILD SEX TOURISM ON THE KENYAN COAST - PRELIMINARY RESULTS AND POLICY IMPLICATIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0201 Jones C.S.1, Ferguson A.2, Mirikau A.3, Dunn J.3 The study demonstrates that it is possible to collect accurate data in difficult-to-reach populations using a combination of traditional and innovative methodologies. It further demonstrates that policy and interventions are frequently based on the false premise that there is a collective repudiation of child sex tourism as a practice. This suggests the need for a radically new approach to curbing child sex tourism. |
| WeAd0202 | ADOLESCENT MSM IN JAMAICA-HIV RISK, HOMOPHOBIA, VIOLENCE AND GENDER STEREOTYPES IN RELATIONSHIPS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0202 Haniff N. This very complex and troubling behavior among many of these youths is directly related to their high HIV infection rates and stifling homophobia More research and good interventions are urgently needed. |
| WeAd0203 | ANAL INTERCOURSE AMONG YOUNG HETEROSEXUALS IN THREE US STD CLINIC POPULATIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0203 Gorbach P.M.1, Manhart L.E.2, Stoner B.P.3, Martin D.H.4 Anal intercourse is common among young heterosexuals attending STD clinics and few report using condoms. Those who practice anal intercourse report other sexual risks such as sex work suggesting a confluence of risks for HIV infection among young heterosexuals practicing anal intercourse. |
| WeAd0204 | HIV RISKS AMONG YOUNG MALE MIGRANTS USING HEROIN IN HANOI, VIETNAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0204 Giang L.M.1, Clatts M.C.2, Goldsamt L.A.2, Yi H.2, Son N.M.1 Young men migrating to urban cities in Southeast Asia like Hanoi for wage labor are clearly at risk of HIV infection. Many are missing in prevention programs that have difficulties in even reaching local residents. The confluence of both drug and sexual risks reflects the complex vulnerability that exists in this population group and the urgent need for prevention programming targeting both drug and sexual risks. |
| WeAd0205 | URBAN YOUTH CULTURES, MASCULINITY AND SEXUAL RISK Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0205 Munoz-Laboy M. The notion of citizenship and rights seem to be influenced by a notion of the "real Hip Hop" and no by other forms of youth culture. The above findings suggest that understanding cultural narratives of masculinity is critical to advance an effective social agenda that promotes gender equity and sexual health among urban youth. |
| WeAd03 | Civil Society Institutions: Caught Between Stigma and Social Responsability |
| WeAd0301 | INNOVATIONS IN EDUCATION: THE ROLE OF THE EDUCATION SECTOR IN COMBATING HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0301 Blackett-Dibinga K.1, Anah K.1, Matinhure N.2 Governments and organizations should consider such innovations that address the needs of the entire communities in order to address the needs of vulnerable groups, especially OVC. |
| WeAd0302 | CHANGES IN ASSOCIATIONAL COMMITMENT IN THE FIGHT AGAINST HIV/AIDS IN SWITZERLAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0302 Voegtli M., Horat S. This historical and comparative study helps us to understand the commitment principles of people involved in associations fighting against HIV/AIDS. This study is particularly important in order to understand the demobilization observed in swiss associations since the introduction of HAART. |
| WeAd0303 | BUDDHISM AS A SUPPORT MECHANISM FOR PEOPLE LIVING WITH HIV/AIDS IN VIETNAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0303 Tran N.T. Providing support through religious institutions is an effective approach in supporting PLWHA and educating the community. Religious leaders have an important role to play in the response to the HIV/AIDS epidemic as compassionate, accepting and influential leaders in society. Building the capacity and strengthening HIV knowledge within religious institutions will provide increased access to support for PLWHA and will contribute towards reducing stigma and discrimination in society. Encouraging PLWHA to look to the pagoda for support will help them have a more positive outlook and can restore hope. |
| WeAd0304 | DOES THE CHURCH DELIVER? PERCEPTIONS AMONGST SOUTH AFRICANS ABOUT THE ROLE OF THE CHURCH IN THE HIV/AIDS FIELD Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0304 Van Dyk P. The church is considered an important support system to HIV-positive people by most South Africans, although some participants thought that the church could do more. Although attitudes towards HIV-positive people and condom usage were mostly positive, negative attitudes were sometimes more prevalent amongst active church members and certain categories of people. |
| WeAd0305 | ASIAN IMMIGRANT COMMUNITY INSTITUTIONS IN NEW YORK CITY (NYC): BARRIERS TO INVOLVEMENT IN HIV-RELATED ACTIVITIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0305 Chin J.J.1, Mantell J.2, Weiss L.1 Understanding the barriers to immigrant organizations' involvement in HIV intervention is a key step in engaging them in HIV-related activities. Given the growing HIV problem in Asian immigrant communities, involvement of these organizations is critical to raising awareness and combating stigma. |
| WeAd04 | The Old and the New: Culture, Communication and HIV Prevention |
| WeAd0401 | REDEFINING AIDS PREVENTION STRATEGIES AMONG YOUTH IN THE MULTICULTURAL SOCIETY OF GUATEMALA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0401 Ikeda J., Yac J., López Tellez C.A. It is important to involve youth representatives in redefining AIDS Prevention Strategies in Multi-cultural countries such as Guatemala. |
| WeAd0402 | BREAKING THE BARRIER: USING TRADITIONAL APPROACHES IN HIV/AIDS PREVENTION FOR MOBILE HERDSMEN AND INITIATES IN LESOTHO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0402 Ochan W.1, Maketha D.2, Hachonda H.3 This approach offers lessons for integrating HIV/AIDS prevention messages in traditional communication channel in reaching rural and pastoral communities more effectively; through their language and design, adapted to their situation and life style. |
| WeAd0403 | CULTURAL RESPONSES TO THE AIDS EPIDEMIC IN UGANDA: THE CHANGING ROLES OF STAKEHOLDERS PROVIDING SEXUAL ADVICE TO YOUTH IN TWO PERI-URBAN SETTINGS IN SOUTHWESTERN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0403 Mbonye M.1, Wolff B.1, Bufumbo L.1, Ssejjaaka P.1, Grosskurth H.2 HIV/AIDS awareness and urban migration are eroding old taboos against direct discussion between parents and children on sexual issues and catalyzing new approaches to informal sex education such as urban aunties for informal sex education. Rise of new traditions reflect continued demand among youth for advice from trusted elders. Greater involvement of different stakeholders should be encouraged to reinforce AIDS prevention messages to reach mobile youth in high-risk environments. |
| WeAd0404 | DYNAMICS IN HIV/AIDS COMMUNICATION INTERVENTIONS: A CASE STUDY OF THE DATOGA SPEAKING PEOPLE, NORTHERN TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0404 Nyoni J. As such we suggest that "interventionists" need to take more seriously social and contextual variables in the communication process. In addition, demystification of HIV/AIDS among indigenous groups like the Datoga would open a common platform whereby conceivers and recipients of HIV/AIDS information would to a large extend be talking about the same thing. |
| WeAd0405 | USING CULTURE TO FIGHT CULTURE: PREVENTING HIV TRANSMISSION BY CHANGING HARMFUL PRACTICES SURROUNDING CIRCUMCISION OF YOUNG MEN IN EAST NUSA TENGGARA, INDONESIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAd0405 Lake P.1, Hakim W.2 The model that will be presented may be applied in settings where harmful traditional practices exists, and suitable cultural mechanisms are available or can be developed. Further efforts should be put into building models of cultural-participatory monitoring. |
| Track E | |
| WeAe01 | Routine and Rapid HIV Testing |
| WeAe0101 | ROUTINE TESTING: ARE WE READY TO THROW HUMAN RIGHTS OUT OF HIV TESTING POLICY? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAe0101 Csete J., Elliott R. Research is urgently needed on the real experience of both VCT and provider-initiated models. This research must meaningfully involve people living with HIV and others who have experienced HIV testing, especially womem tested in antenatal care. |
| WeAe0102 | FCS IN FACILITATION OF VCCT GUIDELINES FOR CHURCHES IN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAe0102 Musa S.A.U.1, Akpo O. E.2, Zakka A.1, Udeoba E. S.3, Mershak B. D. P.4 Church policy development initiatives should emphasise on involvement of all key stakeholders, especially youth and women. |
| WeAe0103 | THE NATIONAL SCALE-UP OF VOLUNTARY COUNSELING AND TESTING (VCT) IN KENYA HAS POTENTIAL FOR ABUSE IN THE COUNSELING ROOM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAe0103 Hamilton C.1, Okoko D.2, Tolhurst R.3, Kilonzo N.2, Theobald S.4, Taegtmeyer M.5 Despite a strong focus on quality assurance and supervision in many VCT sites, the study demonstrates the potential for abuse in the VCT process. This has important implications for policymakers. Further debate around this issue and the application of ethical guidelines and codes of conduct are urgently needed to ensure the protection of clients and providers in the scale-up of VCT and wider HIV/AIDS treatment and care programmes. |
| WeAe0104 | IMPACT OF ROUTINE HIV COUNSELING AND TESTING WITH AN OPT-OUT STRATEGY COMPARED TO VOLUNTARY COUNSELING AND TESTING IN THE IMPLEMENTATION OF PMTCT SERVICES, LILONGWE, MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAe0104 Zimba C.1, Kamanga E.1, Chilongozi D.1, Martinson F.1, Kayambo F.2, Meme J.3, Hoffman I.4, van der Horst C.4 The opt-out approach to HIV counseling and testing was responsible for a 22.5% increase in testing among this antenatal population. It is an acceptable and effective strategy to provide HIV counseling and testing among women attending antenatal clinics in Malawi. |
| WeAe0105 | COUNSELING IN THE USE OF ANTI-HIV RAPID TEST: THE EXPERIENCE OF THE BRAZILIAN AIDS PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAe0105 Serafim D., Ferraz D., Chequer P. Training should emphasize the attention to specific vulnerabilities, include simulated use of the protocol and qualify the relationship between professional and service user. It should include practical exercise of counseling and cases discussion. Counseling protocol for primary care services should be simplified facilitating its insertion in the routine. Periodic monitoring is essential to reinforce service training thus increasing the staff's confidence and ability and guaranteeing the quality of counseling. |
| WeAe02 | Young People Control the Future of the Response! |
| WeAe0201 | JOINT RESPONSIBILITY - JOINT ACTION: CHINA YOUTH NETWORK, A YOUTH-ADULTS PARTNERSHIP IN THE FIGHT AGAINST HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAe0201 Hang C. Young people are the main force and the biggest beneficiary in the fight against HIV/AIDS, especially in a country with a large territory and population of young people like China, where the epidemic is increasing dramatically. However, though the rights of young people are gradually recognized, still huge amount of them don't have access to information and services and are neglected in programs and decision-making at all levels. |
| WeAe0202 | ADOLESCENT PEER EDUCATION: THE NEED FOR FAMILY LIFE AND SEXUAL AND REPRODUCTIVE HEALTH RELATED EDUCATION IN DEVELOPING LIFE SKILL IN BANGLADESH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAe0202 Hasan K. In order to help adolescents earn some means of an income, it is mandatory to give them some type of vocational training. It is not enough to only make sure they participate in peer education programs and acquire vocational training but also to use their acquired knowledge. Therefore, micro credit scheme may be introduced. |
| WeAe0203 | STRENGTHENING YOUTH PARTICIPATION IN NATIONAL REPRODUCTIVE HEALTH (RH)/HIV/AIDS RESPONSES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAe0203 Mahler H., Vasileva-Blazev M. Greater efforts to meaningfully involve youth should be made as it improves the relevance and technical approach to national processes and strategic planning. |
| WeAe0204 | ELECTED YOUTH LEADERS FROM THE POOR REGION OF MINDANAO, THE PHILIPPINES CLAIM THEIR RIGHT TO SEXUAL AND REPRODUCTIVE HEALTH EDUCATION AND SERVICES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAe0204 Datoy M.V.1, Amomonpon D.L.2 Scaling up is indeed a possibility but may seem relevant only in areas which have the same conditions and characteristics as this region. |
| WeAe0205 | Discussant: Sam Ocen, Uganda Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAe0205 Sam Ocen, Uganda Abstract not available. |
| Track X | |
| WeAx01 | Young People Control the Future of the Response! |
| WeAx0101 | SEXUAL TRANSMISSION OF HEPATITIS C AMONG HIV-INFECTED MEN WHO HAVE SEX WITH MEN IN ENGLAND AND WALES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0101 S. Dougan1, M. Balogun2, J. Elford3, L. Brant2, K. Sinka1, B. Evans1, M. Ramsay2 Using national surveillance data in E&W, only 31 MSM co-diagnosed with HIV and hepatitis C were identified. Clinic studies indicate that this is an underestimate of sexually-transmitted hepatitis C among HIV-infected MSM in E&W. Sentinel surveillance data however, indicate that a substantial number of HIV-diagnosed MSM tested hepatitis C positive in E&W during 2003, and that co-infection is not confined to London. |
| WeAx0102 | EFFICACY OF A 24 WEEK COURSE OF ACUTE HCV TREATMENT WITH PEG-INTERFERON A-2B AND RIBAVIRIN IN HIV INFECTED PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0102 Kruk A., Polovinkina N. After 24 week of acute HCV treatment with peg-interferon and ribavirin the majority of treated patients (94%) achieved sustained virological response (negative qualitative HCV RNA 24 weeks after the end of treatment). |
| WeAx0103 | HIGH LEVELS OF RISK IN YOUNG OFFENDERS: AN EPIDEMIC IN THE MAKING – RESULTS OF THE ONTARIO HIV AND HEPATITIS C REMAND STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0103 Calzavara L.1, Ramuscak N.1, Burchell A.1, Myers T.1, Swantee C.2, Ford P.3, Raymond S.4 Despite low HIV and HCV prevalence rates, young offenders are engaging in high-risk behaviours. Unavailability of harm reduction measures in correctional facilities increase the level of risk. Targeted prevention and education programs are needed to ensure that prevalence of blood-borne infections remain at the current low level. |
| WeAx0104 | PREVALENCE OF HIV, HEPATITIS B & C AND SYPHILIS INFECTION SUBSTANCE USERS IN ZANZIBAR TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0104 Dahoma M.1, Salim A.A.1, Abdool R.2, Othman A.A.1, Nganga L.3, Abdullah A.4, Kibuka T.3, Ali A.S.1 Injection drug use and needle-sharing are common among SUs in Zanzibar resulting in high prevalence of blood-borne infections. IDU could present a bridging population for HIV spread into the general population in Zanzibar, and interventions are critically needed to prevent this spread. |
| WeAx0105 | REDUCING HIV/HEPATITIS CO-INFECTION IN EUROPE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0105 Eramova I.1, Munz M.1, Salmon D.2, Malkin J.-E.3 After the protocols, the next steps should include increasing access to the prevention and treatment of hepatitis by raising awareness of hepatitis morbidity as a public health issue, through the development of a price reduction strategy for anti-hepatitis drugs and diagnostics, and increasing access to the HBV vaccination. |
| WeAx0106 | NON-MEDICAL STAFF KNOWLEDGE, ATTITUDES AND PROFICIENCY ABOUT HIV AND HEPATITIS C FOR INJECTION DRUG USERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0106 Rowe K.1, Tesoriero J.1, Heavner K.1, Rothman J.2, Litwin A.3, Birkhead G.2 This study demonstrated that individuals providing HIV services to IDUs have lower knowledge, less favorable attitudes and lower self-rated proficiency towards HCV than they have towards HIV. These barriers should be addressed prior to integrating HCV services into settings already providing HIV services. |
| WeAx02 | Education and AIDS: challenges and possibilities |
| WeAx0201 | ASSESSING GLOBAL READINESS OF THE EDUCATION SECTOR TO MANAGE AND MITIGATE HIV AND AIDS IMPACT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0201 Badcock-Walters P.1, Boler T.2, Carroll K.2, Desmond C.1, Görgens M.1, Heard W.1, Jellema A.3, Kelly M.4, Smart R.1, Wilson D.1, Draxler A.5, Castle C.5, Sass J.5 To institutionalise comprehensive, inclusive responses, MoEs and civil society need to better understand and benchmark the impact of HIV/AIDS on education; identify key problems and omissions in the Sector response; and develop and implement policy and comprehensive, strategic, time-bound plans. |
| WeAx0202 | HIV/AIDS AND TEACHER ABSENTEEISM: IMPLICATIONS FOR ATTAINMENT OF QUALITY EDUCATION IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0202 Twesigye P. HIV/AIDS has impacted on the education sector in Uganda through keeping a big number of teachers absent from work not only for many days but also for long and extended periods. Due to Stigma, many teachers suffer. While they may be physically present at school and in classrooms, they are spiritually absent. |
| WeAx0203 | CAPACITY BUILDING FOR HIV POSITIVE TEACHERS (KENEPOTE) IN KENYA'S EDUCATION SECTOR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0203 Lawson P.J.1, Siparo A.2, Gatua E.2, Wambete M.3, Ouko E.3, Atieno J.4 HIV positive teachers face extreme stigma and discrimination in the education sector. Teachers can play a role to decrease stigma and discrimination, support children and change the way the education sector addresses HIV. |
| WeAx0204 | ARE TEACHERS AND STUDENTS READY TO ACCEPT LESSONS ON HIV/AIDS?: EXPERIENCES FROM BANGLADESH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0204 Ahmed L.1, Ahmed N.U.1, Khan S.I.2, Ali K.B.1, Rasheduzzaman Shah M.1, Chowdhury A.Y.3 Because of preoccupied etic notions of sensitivities, issues related to sexuality and HIV/AIDS receive inadequate attention at educational institutes. However, when well-designed initiatives are taken for actions after providing training to teachers on technical content as well as the methods of initiation of discussion, most of the teachers and students support 'open and free' discussions on so called 'sensitive' issues at classroom settings. This has challenged our conventional views about 'silence' regarding sexuality and given social space to rethink for scaling-up sexuality education program at national level. |
| WeAx0205 | LEADING THE WAY IN THE EDUCATION SECTOR: ADVOCATING FOR A COMPREHENSIVE APPROACH TO HIV AND AIDS IN THE CARIBBEAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0205 Constantine C. Replicating this campaign with Ministries of Education throughout the Caribbean region, will help senior level decision makers understand and address the impact of HIV and AIDS on schools, teachers and society. |
| WeAx03 | Women: Doing Better than Men? |
| WeAx0301 | FOOD INSUFFICIENCY PREDICTS HIGH-RISK SEXUAL BEHAVIOR AMONG WOMEN BUT NOT MEN IN SOUTHERN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0301 Weiser S.1, Leiter K.2, Heisler M3, Percy-de Korte F.4, Hlanze Z.5, DeMonner S.6, Tlou S.7, Phaladze N.7, Iacopino V.2, Bangsberg D.8 Food insufficiency is an important risk factor for increased sexual risk taking among women in Southern Africa. Targeted food assistance and income generation programs may play an important future role in decreasing transmission risk for women. |
| WeAx0302 | DISCLOSURE OF HIV STATUS AMONG SOUTH AFRICAN WOMEN: FACTORS THAT IMPEDE DISCLOSURE AND SUBSEQUENT REPERCUSSIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0302 Forsyth B.1, Visser M.2, Makin J.D.3, De Villiers A.4, Jeffery B.3, Serithi Despite common perceptions, the majority of HIV+ women (81%) do disclose their diagnosis to others, and few experience repercussions. This greater understanding about the consequences of knowing one's HIV status should help promote wider HIV testing. |
| WeAx0303 | REPEAT PREGNANCY IN INDIAN WOMEN WITH KNOWN HIV STATUS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0303 Suryavanshi N.1, Erande A.1, Pisal H.1, Shankar A.2, Phadke M.3, Bolinger R.4, Ssatry J.1, BJ JHU MIT study group, Pune, India The majority of the repeat pregnancies for HIV-positive women were both unplanned and unwanted. Inabilities to terminate the pregnancy and family pressure appear to drive repeat pregnancy in HIV-positive Indian women. Interventions focused on contraception negotiation skills to empower HIV-positive women and involving partners and family, when possible, in postpartum counseling are important to assist women who don't want to become pregnant again. |
| WeAx0304 | HIV-1 POSITIVE RWANDAN WOMEN HAVE A HIGH FREQUENCY OF LONG-TERM SURVIVAL: 20-YEAR FOLLOW-UP FROM A PROSPECTIVE COHORT STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0304 Peters P.1, Meinzen-Derr J.2, Karita E.3, Kayitenkore K.3, Kim D.-J.4, Tichacek A.5, Allen S.5, and the Rwanda Zambia HIV Research Group (www.rzhrg.org) HIV positive Rwandan women have higher rates of long-term survival than predicted by current natural history models of HIV infection in Africa. The majority of these long-term survivors, however, still have evidence of disease progression. |
| WeAx0305 | MORTALITY AMONG PARTICIPANTS IN THE MULTICENTER AIDS COHORT STUDY (MACS) AND THE WOMEN'S INTERAGENCY HIV STUDY (WIHS): IMPACT OF ACCIDENTS AND INJURY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0305 Cohen M.1, Kalinowski A.2, Mullen J.3, Palella F.4, Anastos K.5, Benning L.3, Hessol N.2 The higher risk of deaths from injury and accident among women in WIHS compared to men in MACS warrants further study. The characteristics identified may help target groups and interventions to reduce accidental and injury-related deaths. |
| WeAx04 | Risk and Risk Reduction for Female Sex Workers |
| WeAx0401 | RESEARCH ON HIV/AIDS-RELATED BEHAVIORS OF 986 CLIENTS OF SEX WORKERS IN SICHUAN PROVINCE, CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0401 Wan S.1, Zhang J.2 Clients surveyed are at risk of HIV infection and transmission. They seldom receive health services and intervent. |
| WeAx0402 | SHORT TERM EFFECT OF A CULTURAL ADAPTATION OF VOLUNTARY COUNSELING AND TESTING AMONG FEMALE SEX WORKERS IN CHINA: A QUASI-EXPERIMENTAL TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0402 Li X.1, Wang B.1, Fang X.2, Zhao R.2, Stanton B.1, Hong Y.3, Dong B.4, Liu W.4, Zhou Y.4, Liang S.4, Yang H.1 This quasi-experimental trial provides evidence that the brief VCT intervention, through appropriate cultural adaptation, can be efficacious in increasing condom use and reducing STD infection rate among FSWs in China. |
| WeAx0403 | A JOURNEY OF EMPOWERMENT OF RURAL TRADITIONAL FEMALE SEX WORKERS (RTFSW) IN RAJASTHAN, INDIA: A CASE STUDY FROM RAJASTHAN, INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0403 Mathur A.1, Singh P.2, Moses S.3, Blanchard J.3, O'Neil J.3 Empowering rural traditional female sex workers, their clients and communities to reduce their risk & vulnerability to HIV/AIDS is a unique challenge given historical and cultural conditions. The Saksham project began with an understanding of the rural sex work environment and developed a community relevant HIV/AIDS prevention, care and support program model. |
| WeAx0404 | THE ROLE OF ALCOHOL CONSUMPTION IN TRANSACTIONAL SEX IN MALAWI: A SIGNIFICANT FACTOR FOR HIV PREVENTION INTERVENTION DESIGN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0404 Mack N.1, Alleman P.1, Chaponda M.2, Bula A.2, Hoffman I.3, MacQueen K.1 HIV prevention intervention strategies should accommodate alcohol as a significant risk factor. Alcohol impairment among FSW and clients necessitates a more aggressive approach to condom promotion at HTAs than might otherwise be considered appropriate. |
| WeAx0405 | MEASURING THE EFFECTIVENESS OF INTERVENTION AMONG FEMALE SEX WORKERS (FSW) AND LONG DISTANCE TRUCK DRIVERS (LDTD) THROUGH CROSS-SECTIONAL MEASUREMENT OF TRENDS OF RISKY SEXUAL BEHAVIORS IN THE CORRIDORS OF HOPE PROJECT (COH), ZAMBIA 2000 – 2006 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WeAx0405 Kamanga J.1, Ndubani P.2, Siziya S.3, Long L.1 The results of the third trend point among FSW and LDTD will provide a direction to which intervention activities are going. And will provide the basis on which to re-design current HIV/AIDS strategies and intervention aimed at most high risk populations. |
| Poster Exhibitions | |
| Track A – Biology and Pathogenesis of HIV | |
| WePE0001 | ESCAPE FROM AN HLA-B57-RESTRICTED CTL RESPONSE IN CAPSID REDUCES HIV-1 FITNESS AND RT EFFICIENCY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0001 M.A. Brockman, A. Schneidewind, M.P. Lahaie, B.D. Walker, T.M. Allen Escape in B57-TW10 reduces HIV-1 replication and associates with an early defect in viral DNA generation. Mutation at T242N mutation can be restored partially by compensatory changes in the CyPA binding loop. Complex phenotypes of T242N-containing mutants in the presence of CSA or As2O3 indicate that the escape and compensatory mutations impact capsid function and may alter sensitivity to host restriction. These results highlight an attractive region of p24 for vaccine design. |
| WePE0002 | EVOLUTION AND COMPARTMENTALIZATION OF HIV-1 IN A DUAL INFECTION WITH SUBTYPES B AND G: FULL-LENGTH SEQUENCES FROM PLASMA, PERIPHERAL BLOOD MONONUCLEAR CELLS AND HIV-1 PRIMARY ISOLATES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0002 M. Muñoz-Nieto1, L. Pérez-Álvarez1, G. Casado1, M. Thomson1, A. Ocampo2, E. Delgado1, C. Miralles2, E. Vázquez de Parga1, M. Sierra1, R. Carmona1, Y. Vega1, G. Contreras1, L. Medrano1, R. Nájera1 Intercompartment dynamic of HIV-1 populations involved opposite phenotypic and genotypic variants throughout follow up of one B+G dual infection, with generation of different recombinants, suggesting that virus populations in PBMC may reflect the persistence of variants initially transmitted and that may emerge under different selective pressures. |
| WePE0003 | RECOMBINATION AND FITNESS; COULD IT EXPLAIN THE EMERGENCE AND PREDOMINANCE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) CIRCULATING RECOMBINANT FORM (CRF02-AG) IN WEST AND WEST CENTRAL AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0003 H.F. Njai1, K.K. Arien2, Y. Gali2, C. Clybergh2, W. Jennes3, N. Vidal4, C. Butel4, E. Mpoudi-Ngolle5, M. Peeters4, G. Vanham2 We observed a higher ex vivo replicative capacity of CRF02-AG isolates, independent of the disease stage and biophenotype but dependent on cellular environment. This fitness advantage may contribute to a dominant spread of CRF02-AG over A and G subtypes in West and West Central Africa. |
| WePE0004 | BETWEEN A ROCK AND A HARD PLACE: MODELLING THE INTERPLAY BETWEEN EFFECTIVE SIV GAG-SPECIFIC CD8+ T CELLS AND THE KINETICS OF VIRAL ESCAPE IN MACAQUES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0004 M.Z. Smith1, L. Loh1, C.S. Fernandez1, C.J. Batten1, B. Pratt1, I. Stratov1, R. De Rose1, J. Lin1, D.H. O'Connor2, M.P. Davenport3, A.G. Brooks1, S.J. Kent1 SIV-specific CD8+ T cell responses force viral escape in different ways. We hypothesise that the rate of escape reflects the efficiency of particular T cell responses in eliminating wild-type virus. This suggests that the relative effectiveness of various SIV-specific CD8+ T cell responses is KP9>AF9>KW9. This is the first in vivo definition of the comparative effectiveness of different T cell responses for SIV. Inducing the most efficient T cell responses in designing HIV vaccines could substantially improve their efficacy. |
| WePE0005 | VARIANTS OF DIFFERING REPLICATION CAPACITY (FITNESS) CO-EXIST IN THE QUASISPECIES POPULATIONS OF VIRUSES RESISTANT TO A SMALL MOLECULE CCR5 INHIBITOR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0005 K.G. Anastasopoulou1, A.J. Marozsan1, A. Matet1, A.D. Snyder1, E.J. Arts2, S.E. Kuhmann1, J.P. Moore1 Clonal variants with either increased or decreased fitness can co-exist in populations of viruses resistant to a small molecule CCR5 inhibitor when the selecting compound is absent. In the presence of the inhibitor, all the variants are more fit than the parental, inhibitor-sensitive virus. |
| WePE0006 | DETERMINATION OF EX-VIVO FITNESS OF DIFFERENT HIV-1 SUBTYPES AND INTERSUBTYPE BF RECOMBINANTS CIRCULATING IN ARGENTINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0006 A.E. Rubio1, A. Abraha2, R.M. Troyer2, G. Turk1, E.J. Arts2, H. Salomón1 These findings suggest that although subtype F has a higher fitness than subtype B, the recombination event between these subtypes did not increase the replicative capacity of the BF recombinant in PBMCs. These results further emphasize low fitness of the subtype C, which is now beginning to circulate in Argentina. |
| WePE0007 | MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF PRIMARY ALLELES OF THE HIV-1 VPR PROTEIN DURING THE NATURAL COURSE OF INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0007 G. Jacquot1, E. Le Rouzic1, V. Daneluzzi1, J.-J. Lefrere2, L. Morand-Joubert3, S. Benichou4 The characterization of the vpr alleles from a large number of HIV-1-infected patients is in progress to evaluate the potential impact of the Vpr protein as a virulence factor during the natural course of infection. |
| WePE0008 | MULTI-SITE TISSUE AUTOPSY SAMPLES FROM PATIENTS WITH DEMENTIA AND AIDS RELATED LYMPHOMA SHOW DISTINCT PATTERNS OF HIV EVOLUTION IN VIVO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0008 D. Galligan1, S.L. Lamers2, L. Zhao3, S. Yu4, L. Shagrun5, T. De Oliveira6, M. Salemi7, M.S. McGrath8 The study shows a conservation of ARL HIV between metastatic sites suggesting a critical role for either an ARL specific form of HIV or an expanded macrophage population spreading a homogenous form of HIV DNA. The study provides the basis for a new method to examine the metastatic process via the evolution of a well characterized virus. |
| WePE0009 | EVOLUTION AND SELECTION IN HIV-1 POL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0009 R. Pilon1, A. Burchell2, S. Read3, L. Calzavara2, P. Sandstrom1, Polaris HIV Study Team The evolution of HIV-1 pol nucleotide sequences was largely confined to synonymous sites, suggesting that pol has been maintained at a relatively stable fitness peak over the past 20 years, even with the widespread introduction of ART within this population. Although individual codons within the RT and PR genes are under positive selection in the Polaris cohort, most were also being selected prior to ART becoming available. This suggests that the evolution of HIV-1 pol has been influenced by selective pressures other than the widespread use of ART. |
| WePE0010 | PHYLOGENETIC CHARACTERIZATION OF GAG AND ENV SUBGENOMIC REGIONS FROM HIV-1 ISOLATES IDENTIFIED IN MASHHAD, IRAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0010 H.R. Naderi1, M. Tagliamonte2, M.L. Tornesello2, M. Ciccozzi3, G. Rezza3, R. Farid4, F.M. Buonaguro2, L. Buonaguro2 The phylogenetic analysis of 12 HIV-1 Iranian samples, identified in Mashhad, suggests an A subtype-driven epidemics deriving from the African and not from the Middle-East Countries A-subtype. The clustering pattern and the nucleotide divergence values suggest a recent introduction of the HIV-1 infection in this community. Moreover, the phylogenetic correlation with sequences from Teheran suggest a common origin of the HIV-1 epidemics in the two cities. These first data on HIV-1 subtypes in Iran could represent the starting point for a wider molecular survey to trace the HIV-1 epidemics in the Iranian and Middle-East region. |
| WePE0011 | COMPARATIVE DATA SUMMARY OF THE EFOORA RAPID HIV DIAGNOSTIC TEST Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0011 D. Grosky1, R. Rubenstein2 That the Efoora HIV Rapid Test is used in all settings and in all instances where currently the Aboott Laboratories enzyme immunoassay is used. |
| WePE0012 | CHARACTERIZATION OF CTL IMMUNE RESPONSES TO GAG AND NEF PROTEIN OF HIV-1 SUBTYPE C IN INFECTED INDIAN INDIVIDUALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0012 M. Vajpayee1, S. Mendiratta1, U. Malhotra2, K. Mojumdar1 Correlations observed for Gag and Nef specific T cell responses with plasma viral load would have implications for future vaccine design and trial. All the identified immunodominant regions also correlated with HIV Immunology database (Los Alamos) indicating the importance of Gag and Nef-specific responses in multi-clade vaccine approach. |
| WePE0013 | CHARACTERIZATION OF HIV-1 GAG SPECIFIC T CELL IMMUNE RESPONSES AND CORRELATION WITH PLASMA VIREMIA IN INFECTED INDIAN INDIVIDUALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0013 M. Vajpayee1, S. Kaushik1, K. Mojumdar1, N. Wig2 The results reflect the inability of HIV-1-specific T cell responses to control viral replication during chronic infection in absence of IL-2 help that leads to the probable dysfunction of IFN-γ secreting CD4+ and CD8+ T cells. The identification of these responses at single peptide level across HIV-1 subtype C infected Indian population and correlation with the data from Caucasian population may provide useful insight for the design of new immunotherapies and vaccines for effective control of HIV-1 infection. |
| WePE0014 | LOW CMV-SPECIFIC CD4+ T CELL RESPONSES IN HIV PATIENTS RECEIVING EFFECTIVE ANTIRETROVIRAL THERAPY ARE ASSOCIATED WITH LOW NUMBERS OF PLASMACYTOID DENDRITIC CELLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0014 S. Fernandez1, S. Stone1, P. Price1, M. French2 HIV patients who have increased CD4+ T cell counts on long-term effective ART have low numbers of pDC, which are associated with low CMV-specific CD4+ T cell IFN-γ responses. These findings suggest that inefficient priming and stimulation of antigen-specific T cell populations may be one mechanism by which the reconstitution of antigen-specific T cell responses is hindered in HIV patients receiving ART. |
| WePE0015 | CD31 NEGATIVE NAÏVE CD4+ T CELLS ARE DEPLETED IN HIV-1 INFECTION AND ARE PERMISSIVE TO INFECTION WITH BOTH R5 AND X4 USING HIV-1 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0015 F. Wightman1, A. Solomon1, P. Cameron1, S. Lewin2 Naïve CD4+ T cells expressing platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) have been shown to be recent thymic emigrants. Naïve CD4+ T cells that lose CD31 have proliferated in the periphery in the absence of T cell receptor stimulation and are the subset of naïve cells most frequently infected by HIV-1 in vivo. We hypothesised that in the setting of CD4+ T cell depletion secondary to HIV-1 infection, the pool of CD31 negative naïve CD4+ T cells would be expanded and serve as targets for HIV infection. |
| WePE0016 | HIV-1 INFECTION DOWNREGULATES CELLULAR TELOMERASE ACTIVITY AT NUCLEAR COMPARTMENT OF LYMPHOBLASTOID T CELLS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0016 R. Reynoso, L. Minces, L. Cassino, H. Salomón, J. Quarleri HIV-1 infection is able to downregulate telomerase activity in the nuclear compartment of lymphoblastoid cells. This effect has not emerged by impact on its components -hTERT and hTR- at transcriptional level neither affected the telomere length but exhibited abnormal enzymatic cellular re-distribution. This hypothesis might shed new light on HIV-1 pathogenesis. |
| WePE0017 | CHARACTERISATION OF NEAR FULL-LENGTH GENOMES OF SUBSUBTYPE A3 AND A3/CRF02-AG RECOMBINANT FORMS IN GHANA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0017 E. Delgado1, W. Ampofo2, K. Torpey3, E. Ugly-Kwame2, M. Sierra1, M. Muñoz1, Y.D. Mukadi3, C. Nyarko4, E. Vázquez de Parga1, Y. Vega1, R. Asare5, R. Amenyah3, R. Carmona1, G. Casado1, M. Thomson1, R. Nájera1 Seven near full-length genomes from HIV-1 samples from Ghana have been characterised. These genomes involve subsubtype A3, either alone or as part or intersubtype recombinants with CRF02-AG. The same recombinant pattern shared by three samples could define a new CRF. The unique recombinant patterns found in the other two viruses are derived from dual infections in an area where CRF02-AG, the predominant genetic form, co circulates with A3. Phylogenetic analyses of A3 suggest that A3 viruses might represent an A1 variant which circulates in West African countries, and it is more frequently found as intersubtype A3/CRF02-AG recombinants than as pure A3 viruses. |
| WePE0018 | HIV-1 SUBTYPE A IS THE DOMINANT CLADE IN GREECE IN HIV-1 NEWLY DIAGNOSED PATIENTS DURING 2004 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0018 D. Paraskevis1, E. Magiorkinis1, G. Magiorkinis1, V. Sypsa1, V. Paparizos2, C. Botsi2, N. Stavrianeas2, M. Lazanas3, M. Chini3, N. Mangafas3, P. Gargalianos4, M. Lelekis4, G. Chilomenos4, G. Chrysos5, S. Drimis5, G. Panos6, A. Antoniadou7, G. Poulakou7, G. Koratzanis8, A. Karafoulidou9, O. Katsarou9, A. Skoutelis10, H. Sabatakou11, A. Kontos12, T. Kordossis12, G. Petrikkos13, M. Psichogiou13, M. Theodoridou14, O. Kosmopoulou15, F. Ntziora1, G. Nikolopoulos16, A. Hatzakis1 We report an increasing HIV-1 subtype A epidemic among individuals living in Greece. Subtype A was found to spread mainly through sexual intercourse. Interestingly, subtype A is the most prevalent clade among individuals diagnosed in 2004, therefore suggesting that the HIV-1 epidemic is changing in Greece. |
| WePE0019 | EVOLUTION OF HIV IN KENYA: TRENDS IN HIV DIVERSITY OVER A 2 YEAR PERIOD IN A SEXUALLY TRANSMITTED DISEASE CLINIC IN NAIROBI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0019 R.W. Lihana1, S.A. Khamadi1, M.K. Kiptoo1, E.P. Makokha2, J.G. Kinyua1, M. Mwau1, G.N. Magoma3, N. Lagat1, J. Mwangi1, J. Muriuki1, R. Yamada4, F. Okoth1, E.M. Songok5 The low level of subtype C is in conformity with other reported studies from Kenya. However the noted increase in env subtype D is intriguing. More follow-ups, however, are required to confirm this observation. |
| WePE0020 | IDENTIFICATION OF A NOVEL CIRCULATING RECOMBINANT FORM (CRF33-01B) DISSEMINATING WIDELY AMONG VARIOUS RISK POPULATIONS IN MALAYSIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0020 K.K. Tee1, X.-J. Li1, K. Nohtomi1, K.P. Ng2, A. Kamarulzaman3, Y. Takebe1 We identified a novel CRF disseminating widely among all reported risk groups in Malaysia. This new CRF appears to be bridging viral transmission between different risk populations in this country. |
| WePE0021 | AUTOLOGOUS HIV QUASISPECIES SEQUENCING AND CORRELATIONS WITH CD*+ T CELLS RESPONSES TO VARIANT HIV EPITOPES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0021 L. McKinnon1, X. Mao1, T. Stuart1, S. Kassum1, C. Wachihi2, A. Maingi2, N. Chinga2, K. Fowke1, B. Ball1, F. Plummer1 The heterogeneity of HIV sequences between and within infected individuals can be substantial, and measurements of the epitope specificity of HIV-specific immune responses needs to take into consideration the various strains of HIV that are present at a given time in HIV infection. Natural priming with particular strain(s) of HIV produces populations of T cells with natural cross-reactivity to previously unseen strains in multiple assays measuring multiple aspects of CD8+ T cell activity. |
| WePE0022 | SEARCHING FOR A CRF-B/F IN HIV-1 RECOMBINANT B/F VIRUSES FROM RIO DE JANEIRO, BRAZIL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0022 M.L. Guimarães, J.C. Couto-Fernandez, W. Eyer-Silva, S.L.M. Teixeira, S.L. Chequer-Fernandez, M.G. Morgado So far, four distinct B/F recombinant genetic profiles were found in our work, and none of the analyzed samples gathered with high bootstrap value with CRF12, 28 or 29. |
| WePE0023 | PROTOCOL FOR NEARLY FULL-LENGTH SEQUENCING OF HIV-1 RNA FROM SERUM OR PLASMA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0023 Y. Nadai1, L. Eyzaguirre1, N. Constantine1, F. Cleghorn2, M. Charurat1, A. Sill3, N. Jack4, P. Figueroa5, J. Pape6, E. Guerrero7, W. Blattner1, J. Carr1 A new protocol was developed for sequencing nearly full-length HIV-1 genomes from plasma or serum. The success of the procedure was sensitive to VL but was routinely successful for VL greater than 100,000 copies/ml. The procedure was used to assess the molecular diversity of HIV-1 in the Caribbean. Most of the Caribbean strains were non-recombinant subtype B. |
| WePE0024 | HIV-1 SUBTYPE A DIVERSITY IN RUSSIA: ANALYSIS OF PHYLOGENETIC CLUSTERS AND CHARACTERIZATION OF NEAR FULL-LENGTH GENOME SEQUENCES OF THE PREDOMINANT STRAIN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0024 E. Vázquez de Parga1, M. Thomson1, A. Rakhmanova2, A. Vinogradova3, E. Delgado1, L. Pérez-Álvarez1, G. Casado1, M. Sierra1, M. Muñoz1, R. Carmona1, Y. Vega1, G. Contreras1, L. Medrano1, S. Osmanov4, R. Nájera1 Three phylogenetic subclusters within the HIV-1 subtype A variant in Russia have been identified, and geographic correlations have been defined. Three near full-length genome sequences have been obtained from the predominant strain, which is spreading rapidly among IDUs in Russia and other FSU countries. |
| WePE0025 | SURVEILLANCE OF HIV-1 INFECTION IN FAR NORTH CAMEROON Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0025 H. Gayum, N. Ndembi, L. Kaptue, Laboratoire d'Hématologie et d'Immunologie. Université de Yaoundé I This study highlights the need for ongoing surveillance of HIV-1 variants in Cameroon. More research and funding are deeply needed to better understand crossed reaction among HIV types (1 and 2) and groups (M, N, O) to adapt control measures. |
| WePE0026 | ASSESSMENT OF PHYLOGENETIC ACCURACY FOR RECONSTRUCTING HIV-1 EPIDEMIOLOGICAL RELATIONSHIPS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0026 D. Paraskevis1, A. Beloukas1, E. Magiorkinis1, G. Magiorkinis1, A.-M. Vandamme2, J. Albert3, A. Hatzakis1 We report that under the conditions of our study, HIV-1 epidemiological relationships were truly reconstructed by NJ and Bayesian methods, while ML quartet puzzling method was more dependent on the genetic heterogeneity of the analyzed region. Our results suggest that for particular methods, genomic regions (PR, partial RT) analyzed routinely for HIV-1 genotypic resistance testing, may have insufficient phylogenetic signal for the accurate trace of epidemiological relationships. |
| WePE0027 | PRESENCE OF COMPLEX RECOMBINANT HIV TYPE 1 STRAINS IN MALI: EVIDENCE OF SIGNIFICANT ONGOING VIRUS EVOLUTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0027 H. Imamichi1, O. Koita2, S. Dao2, R.L. Dewar1, S. Berg1, M.K. Jiang1, M. Parta1, M.A. Polis3, H.C. Lane3, A. Tounkara2, The Project Serefo This study demonstrates the recombination-prone nature of HIV-1 in areas such as Mali where CRFs have a high prevalence. It also describes the presence of complex forms of CRF02-AG in West African populations, indicating significant ongoing viral evolution. Creation of new recombinant forms has important implications for vaccine development, diagnostic testing, and treatment strategies. The role of these recombinant viruses in the global pandemic must be monitored on an ongoing basis to detect new variants as they arise. |
| WePE0028 | LIMITED GENETIC VARIATION DURING SEXUAL TRANSMISSION OF HIV-1 KOREAN CLADE B Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0028 B.G. Shin, J.G. Nam, G.J. Kim, J.S. Lee, S.S. Kim Our study on infected pairs of Korean HIV subtype B characterized relatively low genetic variation of HIV-1 env, which were different from other studies on heterosexual group of non-B subtype. This result would be helpful in understanding the evolution of currently distinct HIV-1 korean clade B. |
| WePE0029 | DEMOGRAPHIC GROWTH OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 IN SOUTH AMERICA: IMPLICATIONS FOR THE BF RECOMBINANT EPIDEMICS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0029 E. Leal, R. Diaz, M. Janini Owing to the almost complete absence of subtype F recent infections and the nonexistence of a well-defined epidemic caused by subtype F in South American countries, we suggest that the first recombinant events that resulted in the emergence and expansion of CRFs-BF occurred very close to the clade F introduction in the continent, in the early 1980s. |
| WePE0030 | A QUANTITATIVELY DOMINANT MECHANISM FOR HIV-1 PERSISTENCE IN PATIENTS ON ANTIRETROVIRAL THERAPY INVOLVES ERRORLESS EXPANSION OF INDIVIDUAL VIRAL CLONES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0030 J.R. Bailey, A.R. Sedaghat, T. Kieffer, T. Brennan, P. Lee, M. Wind-Rotolo, C. Haggerty, J.E. Gallant, J. Cofrancesco Jr., T.C. Quinn, C. Wilke, S.C. Ray, J. Siliciano, R.E. Nettles, R.F. Siliciano Antiretroviral therapy reduces HIV-1 viremia to clinically undetectable levels. However, latent HIV-1 persists in the resting CD4+ T cell reservoir, and there are low residual levels of free virus in the plasma. This residual plasma virus can provide important clues regarding the nature of viral persistence in patients with undetectable viral loads. |
| WePE0031 | EVALUATION OF DISCREPANT HIV2 SEROLOGIES IN BAMAKO, MALI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0031 B. Traore1, B. Diarra1, O. Guindo1, Y. Sarro1, J. Warfield2, R. Burges2, H. Imamichi2, R. Dewar2, V. Natarajan2, A. Tounkara1, M. Parta3, Serefo Team Serologies provided discrepant results and poor predictive value for the presence of HIV2 in Mali. ¼ specimens reactive by BioRad LAVII and ½ by Multispot were confirmed by PCR as containing HIV2. Sequence of the HIV2 seroreactive specimens found HIV1 AG2 in 1 of the 2 specimens. The diversity of HIV subtypes in West Africa may necessitate more than one assay to resolve discrepancies found by current methodologies. |
| WePE0032 | DETECTING SHIFTS IN HIV-1 DIVERSIFICATION RATES WITHIN PATIENTS: A LANGUAGE-BASED ANALYSIS OF RECONSTRUCTED SEQUENCE PHYLOGENIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0032 A. Poon, S. Frost We find strong evidence for shifts in HIV-1 diversification rates along lineages within patients. This method provides a unique characterization of the selection pressures imposed on HIV-1 that is not captured by methods based on substitution rates. |
| WePE0033 | HIV-1 MOLECULAR EPIDEMIOLOGY IN CUBA: ANALYSIS OF EPIDEMIOLOGICAL CORRELATIONS OF GENETIC FORMS AND INTRACLADE SUBCLUSTERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0033 M.J. Bleda1, M.M. Thomson2, M. Sierra2, L. Pérez3, C. Aragonés3, Z. González3, J. Pérez3, Y. Vega2, E. Delgado2, G. Casado2, R. Nájera2 Phylogenetic subclusters were found in the main HIV-1 genetic forms of Cuba, which allowed to identify intraclade recombinants. Statistically significant associations of some genetic forms and subclusters with risk exposure and/or region support the existence of diverse HIV-1 transmission networks in Cuba. |
| WePE0034 | A COMPARISON OF CORECEPTOR PREDICTION PROGRAMS FOR SUBTYPE C HIV-1 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0034 E. Johnston White, B. McColgan, D. Katzenstein Informatics programs developed with subtype B, do not perform accurately in subtype C virus isolates. Geno2pheno had the highest rate for correctly predicting X4 tropism, followed by the PSSM program. Biological clones, as compared to virus isolates demonstrated improved prediction in the PSSM program, suggesting that population sequencing results may miss X4-tropic variants. |
| WePE0035 | TOWARD THE UNDERSTANDING OF THE EFFECT OF DISTAL DRUG RESISTANT MUTATIONS OF HIV-1 PROTEASE. MOLECULAR DYNAMICS SIMULATION STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0035 D. Kovaslkyy First, we have shown that the effect of distal mutations L10I and L90M on changes of conformational dynamics is evident. Second, mechanisms of action of L10I and L90M mutations are different. Third, effect of combination of the mutation could rationalized based on contribution of each of them with respective mode. |
| WePE0036 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0036 Abstract unavailable. |
| WePE0037 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0037 Abstract unavailable. |
| WePE0038 | INSERTIONAL INACTIVATION OF HIV-1 PROVIRUS DNA: A NOVEL GENE THERAPY STRATEGY TO INHIBIT HIV REPLICATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0038 R. Nazari1, S. Joshi2 Our results demonstrate for the first time that the mobile group II intron insertion within the HIV-1 provirus DNA can inhibit virus replication. These introns are now being exploited for developing an intron-based strategy for HIV gene therapy. |
| WePE0039 | INHIBITION OF HIV-1 ENTRY USING ONCORETROVIRAL AND LENTIVIRAL VECTORS EXPRESSING A MULITMERIC HAMMERHEAD RIBOZYME Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0039 R. Nazari1, S. Joshi2 We conclude that the anti-CCR5 multimeric hammerhead ribozymes can inhibit replication by preventing HIV-1 entry. These vectors will now be tested in CD34+ stem cells. |
| Track B – Clinical Research, Treatment and Care | |
| WePE0040 | EFFECT OF BASELINE FIBROSIS ON THE SAFETY AND EFFICACY OF PEGINTERFERON α-2a (40KD) (Pegasys®) PLUS RIBAVIRIN (Copegus®) IN HIV-HCV CO-INFECTED PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0040 J. Sasadeusz1, E. Godofsky2, R. Sterling3, B. Clotet4, S. Staszewski5, V. Soriano6, A. Rieger7, J. De Pamphilis8, F. Torriani9 Higher response rates with PegIFNα-2a(40KD) plus ribavirin in patients with fibrosis stages 0 – 4, compared to stages 5 – 6, support early use of this regimen in patients with HIV-HCV co-infection. |
| WePE0041 | EFFECT OF THE IL-6 GENE POLYMORPHISM ON TREATMENT OF ACUTE AND CHRONIC HEPATITIS C IN HCV/HIV CO-INFECTED PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0041 J. Nattermann, M. Vogel, G. Ahlenstiel, M. Schulz, T. Sauerbruch, J.K. Rockstroh, The Kompetenznetz HIV/AIDS HIV/HCV+ IL6 HP patients treated with IFN ribavirin combination therapy achieve significantly improved SVR, presumeably because of higher IL6 expression levels. This effect is particularly prominent in infection with difficult-to-treat HCV strains and strengthens the concept that host genetic factors can at least in part affect the response to HCV therapy also in HIV/ HCV co-infected patients. |
| WePE0042 | CYTOKINE PROFILES IN HIV/ HEPATITIS C CO-INFECTED DRUG USERS IN MIAMI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0042 M.K. Baum1, R. Duan1, L. Xue1, D.T. Jayaweera2, A. Campa1 The HIV/HCV co-infected group had significantly lower serum Th1 and Th2 cytokines, and significantly more pathological symptoms than those infected with HIV alone. In HIV/HCV co-infection, reduced antioxidant levels (plasma zinc) were associated with higher pro-inflammatory IL-6 cytokine indicating that HCV/HIV co-infection may increase requirements for antioxidants. |
| WePE0043 | INTERFERON-α NEUROPSYCHIATRIC ADVERSE EFFECTS(AE) IN HIV/HCV CO-INFECTED PATIENTS: A COST-EFFECTIVE BENEFIT RATIONAL FOR A PRE-TREATMENT PROPHYLAXIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0043 S. Compostella, P. Nasta, S. Antonelli, F. Gatti, C. Zeni, A. Matti, G. Carosi This pilot deep analysis of neuropsychiatric disorders in HIV/HCV co-infected subjects show an high rate of disturbances: 85% of studied patients have at least one fragile psychic aspect. This observation may offer a rational to implement a multidisciplinary approach and to perform a future trial on preventive antidepressants in this population. |
| WePE0044 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0044 Abstract unavailable. |
| WePe0045 | RESPONSE OF HEPATITIS B VACCINATION IN HIV POSITIVE HOMOSEXUAL MEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePe0045 S. Emmett1, K. Sheppard1, P. Gomez1, L. Morison2, N. O'Farrell3 The response rate (HbsAb > 10) was greater amongst those with a higher CD4 count. Consideration should be given to revaccinating non-responding HIV positive patients that were vaccinated initially with CD4 counts < 200 if their CD4 count subsequently rises above 200 following the initiation of antiretroviral therapy. |
| WePe0046 | FACTORS ASSOCIATED WITH SERONEGATIVE CHRONIC HEPATITIS C VIRUS INFECTION IN HIV-INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePe0046 G. Chamie1, M. Bonacini2, D. Bangsberg1, C. Hall3, J. Stapleton4, E.T. Overton5, R. Scherzer6, P.C. Tien7 Anti-HCV- HIV+ individuals with elevated ALT should undergo HCV RNA testing, especially those with CD4 < 200 and history of IDU (as expected because IDU is a risk factor for HCV). Analysis of HIV+ subjects with detectable HCV RNA suggests that patients with CD4 < 200 and younger patients, and those without a history of IDU are more likely to be anti-HCV-. Investigation of how immunosuppression and viral factors impact serologic detection of HCV in specific populations is therefore needed. |
| WePe0047 | REVERSAL OF END STAGE LIVER DISEASE IN PATIENTS WITH HIV/HBV-RELATED CIRRHOSIS TREATED WITH TENOFOVIR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePe0047 G. Matthews, D. Cooper, G. Dore TDF is well tolerated in HIV/HBV cirrhosis and not only results in significant HBV viral suppression but may also result in eAg loss/seroconversion. Improvements in hepatic function and reversal of Child-Pugh status suggest that TDF may ultimately alter the natural history of liver disease in HIV/HBV co-infected individuals. |
| WePe0048 | TRENDS AND RISK FACTORS ASSOCIATED TO INCIDENCE OF TUBERCULOSIS IN HAART TIMES IN A MULTICENTRE HOSPITAL-BASED COHORT IN SPAIN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePe0048 S. Moreno1, I. Jarrin2, M.A. Rodríguez-Arenas2, M.J. Perez Elias1, J.A. Iribarren3, P. Viciana4, J. Parra5, J.L. Gomez-Sirvent6, M. Saumoy7, J. Lopez-Aldeguer8, F. Gutierrez9, J.R. Blanco10, S. Perez-Hoyos11, J. del Amo2, S. Padilla Urrea12, CoRIS-MD Important declines in incident TB, the commonest AIDS defining condition in Spain, are being observed over the calendar years studied. IVDU, subjects presenting with advanced HIV disease and those not receiving antiretroviral therapy are the groups most at risk. Incidence of TB in subjects receiving HAART was very low, highlighting the role of HAART in reducing the burden of TB. Spanish Medical Research Fund (FIS) through RIS nº173. |
| WePe0049 | PROTEASE INHIBITOR BASED HAART IS ASSOCIATED WITH PROGRESSION OF LIVER FIBROSIS IN HCV CO-INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePe0049 M. Klein, T. Murphy, R. Lalonde In HIV-HCV co-infection, fibrosis progression is accentuated during exposure to HAART, particularly PI based regimens. A small but significant increase in APRI in HIV mono-infection was also seen which may represent low-grade cumulative hepatotoxicity. |
| WePe0050 | IMPACT OF HBV AND HCV CO-INFECTIONS ON THE RESPONSE TO HIGHLY ACTIVE ANTIRETROVIRAL THERAPY OF HIV-1-INFECTED PATIENTS AT JOS UNIVERSITY TEACHING HOSPITAL, NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePe0050 N. Gwamzhi1, O. Agbaji1, P. Agaba1, G. Onwuegbuzie1, P. Badung1, G. Imade1, J.-L. Sankale2, J. Idoko1, P. Kanki2 HIV-1 co-infection with Hepatitis B and/or C has no significant impact on the response of patients to HAART but may negatively affect toxicity, CD4 cell recovery and HIV-1 viral load reduction on the long term. |
| WePE0051 | CHARACTERISTICS AND PREDICTORS OF HEPATIC FLARES WITHIN A RANDOMIZED STUDY OF HBV THERAPY IN ANTIRETROVIRAL (ARV) NAÏVE HIV/HBV CO-INFECTED PATIENTS IN THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0051 A. Avihingsanon1, G.V. Matthews2, S.R. Lewin3, P. Petcharapirat4, R. Rerknimitr4, P. Marks2, E. Knight2, J. Sasadeusz5, D.A. Cooper2, S. Bowden6, S. Locarnini6, K. Ruxrungtham1, G.J. Dore2 In this population with advanced HIV disease HF after initiation of HBV-active HAART is relatively common and may be clinically significant, especially in advanced liver disease. HF was associated with higher baseline ALT and higher HBV DNA after one month of treatment. |
| WePE0052 | HIV-INFECTED LIVER AND KIDNEY TRANSPLANT RECIPIENTS: 1- AND 3-YEAR OUTCOMES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0052 M. Roland1, B. Barin2, L. Carlson3, L. Frassetto3, N. Terrault3, R. Hirose3, C. Freise3, L. Benet3, N. Ascher3, J. Roberts3, B. Murphy4, M. Keller4, K. Olthoff5, E. Blumberg5, K. Brayman6, S. Bartlett7, C. Davis7, J. McCune3, B. Bredt3, D. Stablein2, P. Stock3 Patient and graft survival rates are similar to the overall transplant population. HCV progression is a concern. There was no significant HIV disease progression. Despite kidney rejection episodes, renal function was good. |
| WePE0053 | PREVALENCE OF CHRONIC HEPATITIS C VIRUS ((HCV) AND HEPATITIS B VIRUS INFECTION (HBV) IN A LARGE COHORT OF HIV-INFECTED SPANISH CHILDREN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0053 J.T. Ramos1, S. Guillén1, P. Barreiro2, R. Resino3, J. Beceiro4, C. Calvo5, M.I. de José6, M.D. Gurbindo7, J. Martínez-Pérez8, P. Martín-Fontelos9, M.J. Mellado9, M.A. Muñoz-Fernández3, M.L. Navarro7, M.A. Roa10, B. Rubio11, Cohort of Madrid HCV and HBV prevalences are low in HIV-co-infected Spanish patients, but higher than in non-HIV-infected children. Vertically HCV-co-infected children are entering adolescence with apparent low hepatic fibrosis by elastography, although patients may have histologic progression. Liver disease in HCV and HIV-co-infected children is of great concern and warrants studies on outcome treatment. |
| WePE0054 | SAFETY OF ATAZANAVIR (ATV) AND ATAZANAVIR/RITONAVIR (ATV/R) IN SUBJECTS CO-INFECTED WITH HIV AND HEPATITIS B AND/OR C: 1100 SUBJECT-YEARS OF TREATMENT EXPOSURE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0054 J. Witek1, S. Mc Callister2, L. Odeshoo3, A. Thiry3, D. Frederick3, E. Ledesma3, J. Hammond3 Similar to other ARVs, subjects with HBV and/or HCV co-infection had a higher rate of G3/4 ALT/AST elevations. In contrast, G3/4 bilirubin elevations, overall AEs and liver-related AEs, had a comparable frequency in subjects with/without coinfection, suggesting that ATV and ATV/r are safe treatment alternatives in this population. |
| WePE0055 | CHRONIC HEPATITIS C IN PATIENTS WITH AND WITHOUT HIV INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0055 J. Méndez1, A. Horta1, A.P. Tavares1, O. Vasconcelos1, H. Coelho1, J. Seabra1, L. Pinho2, F. Carneiro3, R. Sarmento e Castro1 Co-infected pts had higher RNA-HCV, NIA and fibrosis although differences didn't reach statistical significance. Globally, G2/3 induced higher NIA and fibrosis and probably higher viremia than G1/4. In HCV group G2/3 pts tended to have higher viremia and fibrosis than G1/4. In HCV-HIV group G2/3 pts tended to have higher fibrosis. PEG plus ribavirin treatment was significantly associated with viral reduction and lower NIA in all pts and fibrosis regression in HCV group but not in HCV- HIV. |
| WePE0056 | IMPACT OF OCCULT HBV INFECTION IN HIV PATIENTS NAÏVE FOR ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0056 P. Filippini1, N. Coppola1, R. Pisapia1, C. Marrocco1, A. Zaccariello1, C. Nacca2, G. De Stefano3, C. Sagnelli1, T. Ferraro4, C. De Stefano5, E. Sagnelli1 The study suggests that HBV occult infection, relatively frequent in anti-HIV positive patients, is frequently involved in the pathogenesis of hepatic flares. |
| WePE0057 | PREVALENCE OF HEPATITIS C VIRUS (HCV) AND CHRONIC HEPATITIS B VIRUS (HBV) INFECTIONS AMONG HUMAN IMMUNODEFICIENCY VIRUS TYPE-1-INFECTED CHILDREN, ABIDJAN, CÔTE D'IVOIRE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0057 F. Rouet1, A. Inwoley2, M.-A. Anaky3, P. Fassinou4, M.-L. Chaix5, P. Msellati6 This high prevalence of hepatitis B and high rate of replicative infection show the interest to use HAART with lamivudine component in co-infected children with HIV and HBV. |
| WePE0058 | HEPATITIS C CO-INFECTION IN HIV PATIENTS IS NOT ASSOCIATED WITH HIGHER RATE OF ANTIRETROVIRAL CHANGE. FOUR YEARS OF FOLLOW UP Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0058 N. Porteiro1, H. Mingrone1, S. La Rosa2, E. Loiza1 Overall, HIV/HCV prevalence was 46.8%. In this cohort, HIV/HCV co-infection was not statistically associated with higher rate of ARV change after four years of follow up (p=0.1). |
| WePE0059 | MORE CO-INFECTED HIV/HCV PATIENTS ARE ULTIMATELY CLEARED FROM HCV BY PEGYLATED IFN+RIBAVIRIN TREATMENT IF HCV-RNA UNDETECTABILITY AT WEEK 4 IS USED AS PREDICTIVE PARAMETER OF SUSTAINED RESPONSE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0059 M. Setti1, B. Bruzzone2, R. Villa1, S. Blanchi1, M. Basso1, N. Pelli1, A. Picciotto1, F. Indiveri1 Reportedly, about 50% co-infected patients are currently considered eligible for treatment against HCV, less offered, 10% actually treated, about 5% healed. With different strategies, starting from proposing a 4 week treatment to be continued only in documented, motivated responders, human and material resources could be better focused and greater proportion of potential responders enrolled and ultimately healed, beyond the risk of losing some improbable late responder. |
| WePE0060 | THE PREVALENCE OF HIV-1, HEPATITIS B (HBV), HEPATITIS C, (HCV), AND CO-INFECTIONS AMONGST IN-PATIENTS IN A LARGE AFRICAN TEACHING HOSPITAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0060 M. Nyirenda1, M. Beadsworth2, P. Stephany1, C. Munthali1, T. Lomgwe1, T. Hart3, E. Zijlstra1 The HIV prevalence is consistent with previous studies. However, if the HBV serology is confirmed further studies of the effects of Triomune® in co-infection should be considered. |
| WePE0061 | C REACTIVE PROTEIN (CRP) AND HEPATITIS C IN HIV+ DRUG USERS IN MIAMI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0061 R. Duan1, A. Campa1, M. Zaveri1, S. Sales1, L. Xue1, D.T. Jayaweera2, J.B. Page2, M.K. Baum1 Elevated CRP, a marker of systemic inflammation appears to be a less sensitive marker in the presence of HCV infection, despite elevated symptoms of inflammatory pathology. As expected, HCV co-infection was strongly associated with liver dysfunction as shown by higher ALT, AST and LDH. These findings suggest that when HCV co-infection is present, CRP is a less useful indicator and other markers may be required to define inflammation. |
| WePE0062 | ANALYSIS OF HEPATIC EVENTS AFTER NEVIRAPINE CONTAINING REGIMENS IN THE REAL LIFE BY CD4+, GENDER AND HCV COINFECTION. RESULTS FROM A SINGLE CENTRE STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0062 C. Torti1, G. Lapadula1, M. Puoti1, G. Paraninfo2, S. Casari2, F. Castelnuovo2, E. Quiros-Roldan1, G. Cristini2, M.C. Uccelli1, S. Costarelli1, G. Cologni1, V. Tirelli1, M.A. Forleo1, A. Patroni1, G. Carosi1 Most of the excess rates of grade = III LTE's in patients prescribed NCR's could be attributed to HCV co-infection, not differently from other HAART regimens. The incidence of hepatic events after NCR's did not appear a major concern in our cohort of mainly experienced patients overall, and especially in those who are HCV-negative with CD4+ <250 (females) or <400/mm3 (males). |
| WePE0063 | PREVALENCE OF COMPARTMENTALIZED HPV IN HIV-INFECTED MEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0063 S. Agarwal, A. Golembieski, I. Brar, N. Markowitz, D. Baxa Both high-risk and low-risk HPV were detected in anal, oral and PBMC specimens. There was no relationship between specific HPV types identified and compartments tested. Immunosuppression was associated with an increased number of HPV genotypes. These data demonstrate the high prevalence of HPV in HIV-infected men and suggest the need to develop HPV screening protocols for males. |
| WePE0064 | POSITIVES TO POSITIVES SUPPORT- THE KEY TO A SUCCESSFUL ART PROGRAMME - REACH OUT'S EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0064 A.-T. Stella Community based models with a real-life situation approach to patient preparation, and strategies to enhance adherence are desired.PLWHA are role models, and should be involved in offering care and support at various levels in the community. |
| WePE0065 | EVALUATION OF WORLD HEALTH ORGANIZATION CRITERIA FOR ANTIRETROVIRAL TREATMENT FAILURE IN RESOURCE-LIMITED SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0065 P. Mee1, K. Fielding1, S. Charalambous2, M. Eisenstein2, L. Pemba2, C. Innes2, G. Churchyard2, A. Grant1 Clinical and CD4 criteria for treatment failure are insensitive in detecting treatment failure. Low specificities and positive predictive values indicate many with adequate levels of virological suppression would be incorrectly assessed as treatment failures, resulting in potentially unnecessary switching to second-line therapy. Better techniques to assess ART treatment failure in resource-limited settings are required. |
| WePE0066 | NATIONAL SCALE UP OF ANTIRETROVIRAL THERAPY IN MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0066 E. Libamba1, S. Makombe1, A. Harries1, E. Schouten2, D. Lungu3 Adherence to a structured and simple national ART programme can enable rapid scale up of treatment to patients in need. |
| WePE0067 | ANTIRETROVIRAL THERAPY IMPROVES SURVIVAL AND DECREASES TUBERCULOSIS IN ETHIOPIAN HIV PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0067 D. Dare1, A. Næss2, B. Lindtjørn3 HAART improved survival and decreased tuberculosis incidence to a level similar to that achieved in the developed countries during the early years of HAART. However, the tuberculosis incidence rate is much higher in this resource-limited setting. The high tuberculosis incidence rate when coupled with the improved survival can lead to increased tuberculosis transmission.This highlights the need for strengthening tuberculosis prevention efforts along with the scale-up of treatment programmes. |
| WePE0068 | ACCESS TO CD4 TESTING IN RESOURCE-LIMITED SETTINGS: IMPACT OF CLINICAL AND IMMUNOLOGIC STAGING ON ANTIRETROVIRAL ELIGIBILITY IN MTCT-PLUS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0068 M. Rabkin, M. Katyal, R. Carter, J. Austin, J. Kim, P. Toro, W. El-Sadr, E. Abrams, D. Nash 92% of patients eligible for ART were identified using CD4 and would have been missed using WHO staging alone until they developed WHO4 disease . The availability of CD4 testing greatly expands the ability to identify patients requiring ART, especially among pregnant women. |
| WePE0069 | VIRAL SUPPRESSION FOLLOWING MODIFIED DIRECTLY OBSERVED ANTIRETROVIRAL THERAPY IN HIV – INFECTED CAMBODIAN CHILDREN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0069 S. Sophan1, D. Pugatch2, H. Joseph I3, K. Luzuriaga4, M. Somasundaran4, Y.M. Chhour5, P. Polidy6 MDOT-HAART appears to be a feasible and promising strategy to optimize medication adherence for children beginning on antiretroviral treatment. |
| WePE0070 | KNOWLEDGE AND ATTITUDES TOWARDS ART AND RELATED PREVENTIVE BEHAVIORS AMONG RURAL SOUTH AFRICAN YOUTH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0070 M. Lurie1, A. Harrison2, P. Kunene3, M. Kubeka3, N. Williams1 Knowledge about some aspects of ART is high among rural youth, but many misperceptions are evident. The expansion of treatment will have limited success unless young people fully understand the benefits and risks of testing and treatment with ART. |
| WePE0071 | DEVELOPMENT AND EVALUATION OF A VISUAL DOSING AID TO FACILITATE PEDIATRIC ANTIRETROVIRAL TREATMENT ROLL OUT IN RESOURCE POOR SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0071 S. Callens1, D. Westreich1, A. Van Rie1, F. Kitetele2, J. Lusiama2, P. Lelo2, T. Belhorn3, R. Colebunders4, F. Behets1 The VDA performed well in children of both settings. This visual dosing aid can be adapted easily to locally available antiretroviral formulations, potentially reducing dosing errors and time spent on dosing. |
| WePE0072 | FIVE YEARS OF FREE ART IN RESOURCE-LIMITED SETTINGS: THE EXPERIENCE IN KHAYELITSHA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0072 E. Goemaere1, M. Darder1, K. Hilderbrand1, A. Boulle2, G. van Cutsem1, S. Mathee3, P. Saranchuk1, C. Cragg3, L. Kaarse3, D. Coetzee2 Scale up has been successful. Mortality has fallen, patient retention and adherence is excellent, and CD4 count at initiation has risen over time. Unique challenges are presented by maturing cohorts in resource-limited settings, including access to newer, costlier antiretroviral drugs for patients failing first-line, the need to expand the service beyond dedicated HIV clinics, and the high incidence of tuberculosis. Further simplification and standardised approaches are required to cope with future challenges. |
| WePE0073 | RISK OF CNS-COMPARTMENT FAILURE ON PI MONOTHERAPY (ATARITMO-STUDY) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0073 P. Vernazza1, S. Daneel1, V. Schiffer2, L. Decosterd3, T. Klimkait4, B. Hirschel2, and the Swiss HIV Cohort study Limited penetration of PI into CNS may result in replication of wild-type HIV-RNA in the CNS in a relevant subset of patients. As the consequence of low-level HIV replication in different compartments is not known, future monotherapy trials should include careful monitoring of compartments other than blood. Mono-maintenance, however, might be a valid option for future studies. |
| WePE0074 | CLINICAL AND IMMUNOLOGICAL LONG-TERM OUTCOMES ON ADULTS AFTER 3 YEARS OF ART IN "M&EACUTE;DECINS SANS FRONTI&EGRAVE;RES (MSF)" PROGRAMS: A MULTICENTRIC ANALYSIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0074 D. Sauvageot1, L. Ferradini2, Médecins Sans Frontières - AIDS Working Group After three years of ART, survival, tolerance, immunological and nutritional parameters are encouraging. These findings show the long-term feasibility and effectiveness of ART in resource-poor settings. |
| WePE0075 | INCREASING COVERAGE LINKED TO IMPROVED CLINICAL OUTCOMES IN THE SUCCESSFUL SCALE UP OF ANTIRETROVIRAL TREATMENT IN THE WESTERN CAPE PROVINCE OF SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0075 F. Abdullah1, P. Bock2, M. Osler2, A. Boulle2 Limited coverage is a key determinant of high early mortality on HAART. Excellent coverage (3×5 target reached) and adherence are possible in this setting. The five key implementation issues facilitating rapid expansion in the last two years were securing reliable drug supply, involvement of clinicians in programme planning, a basics first approach to routine monitoring, strategic involvement of international and local partners and involvement of community activists in referral, treatment literacy and adherence support. |
| WePE0076 | SUBTYPE-K INFECTED PATIENTS RECEIVING ART IN BURKINA FASO AND MALI DEVELOP RESISTANCE TO NRTIS PREFERENTIALLY ALONG THE 67 – 70 PATHWAY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0076 M. Sylla1, P. Niamba2, S. Dakouré2, A. Traoré2, C. Boileau3, A. Chamberlan1, N. Machouf4, S. Rashed3, V.-K. Nguyen3, C. Tremblay1, Pro-ARV Group Resistance pathways have been well-described for B clade HIV. While expanding use of ART in developing countries has not yet demonstrated any clinical difference in these pathways in non-B viruses, concern remains that resistance to ARVs may proceed differently in non-B clades. We describe resistance mutations in 9 patients harbouring a recombinant K strain, a rare recombinant described mainly in West Africa. |
| WePE0077 | NATIONAL TRAINING AND ACCREDITATION FOR ANTIRETROVIRAL THERAPY SCALE UP IN MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0077 S. Makombe1, E. Libamba1, A. Harries1, S. Phiri2, R. Weigel3, J. van Oosterhout4, E. Zijlstra4, E. Schouten5, D. Lungu6 The trainings and accreditation assessments have laid the foundations for delivering ART in health facilities in Malawi. ART teaching is also being integrated into the curricula of various training colleges, and must remain a vital component of sustaining and scaling up the treatment response. |
| WePE0078 | EFFECTS OF ANTIRETROVIRAL THERAPY ON BONE AGE IN PERINATALLY-INFECTED HIV-POSITIVE ADOLESCENTS IN SUB-SAHARAN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0078 H. Kisembo1, S. Bakeera-Kitaka2, L. Zollinger3, C. Snider4, A. Kekitiinwa2, A. Maganda2, C. Foster5, M. McKellar6 HIV-positive adolescents present with delayed skeletal age when compared to chronological age. These data suggest that introduction of HAART does not markedly restore radiologically-ascertained growth after one year. |
| WePE0079 | BARRIERS TO RAPID INITIATION OF ART IN A COHORT OF HIV POSITIVE UGANDAN ADULTS WITH CD4 COUNTS LESS THAN 200 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0079 R. Parkes1, I. Namakoola2, J. Todd2, I. Kalanzi3, M. O hIarlaithe4, N.K. Mugisha5, H. Grosskurth2, D. Lalloo1, A. Kamali2 Despite adequate ART drugs, laboratory and medical resources, 40% of eligible study participants had not started ART within 3 months of study enrolment. Whilst many of the delays were for medical reasons; domestic and social issues affecting patients need to be addressed to improve rapid access. |
| WePE0080 | THE ANALYSIS OF ART REGIMENS USED IN SEVEN DEVELOPING COUNTRIES: IMPACT ON FORECASTING NEEDS AND RATIONAL DRUG USE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0080 L. Akhlaghi Worldwide ARV usage harmony and compliance with WHO guidelines ensure the durability of regimens; make it easier to estimate future drug needs; help keep costs down by facilitating joint procurement and reducing product prices; and decrease the emergence of ARV resistance, thereby preserving future treatment options. Although these seven countries include many regimens in their ART policies, they are generally abiding by WHO's four recommended guidelines for almost all of their patients. |
| WePE0081 | 5-YEAR PLAN FOR ANTIRETROVIRAL THERAPY SCALE UP IN MALAWI: 2006 – 2010 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0081 A. Harries1, S. Makombe1, E. Libamba1, E. Schouten2, D. Lungu3 Potential solutions to constraints and risks will need to be implemented if ART expansion is to progress satisfactorily. |
| WePE0082 | TOXICITY OF NEVIRAPINE IN HIV-INFECTED WOMEN WITH HIGH CD4 COUNTS IN MALAWI: THE BAN STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0082 B. Bramson1, C. Chasela2, C. Chavula2, N. Numba2, M. Majawa2, M. Hosseinipour1, Y. Ahmed3, A. Kourtis3, R. Knight4, R. Jafali5, G. Tegha2, G. Joaki2, H.-C. Tien6, L. Hyde2, P. Kazembe7, D. Jamieson3, C. van der Horst1, the BAN Study Given the high incidence of NVP-related toxicities in women with high CD4 counts, chronic NVP treatment should not be used in such patients. |
| WePE0083 | RESULTS OF ACTIVE MANAGEMENT OF INITIAL VIROLOGICAL FAILURE IN A LARGE COMMUNITY-BASED ANTIRETROVIRAL PROGRAMME IN SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0083 C. Orrell1, G. Harling1, R. Kaplan2, M. McNally2, S. Lawn3, L.-G. Bekker1, R. Wood1 Use of an intensive counsellor-based adherence intervention targeted at patients with a viral load >1000 copies/ml was associated with a 71% reduction in the proportion with a second viral load >1000 copies/ml and a low rate of switching to second line. |
| WePE0084 | IS ALT CONTROL REALLY NECESSARY FOR ROUTINE ART MONITORING IN RESOURCE POOR SETTINGS? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0084 P. Di Mattei, Mozambique Team - Medecins Sans Frontieres Our data show a very low incidence of liver toxicity in patients taking d4T/3TC/NVP. Besides specific patients (pregnant women, TB patients or patients symptomatic for liver dysfunction), the pertinence in terms of cost/efficacy of regular ALT tests should be questioned. Further analysis will be needed to reinforce our evidence, to identify possible factors associated with liver toxicity and likely timing of occurrence. |
| WePE0085 | HEALTHCARE UTILIZATION BY A COHORT OF LATE-STAGE HIV-POSITIVE PATIENTS COMMENCING ANTIRETROVIRAL MEDICATION IN SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0085 G. Harling, C. Orrell, R. Wood In a cohort of patients with advanced disease the commencement of ART led to reductions in both inpatient and outpatient demand for care, with inpatient demand falling most rapidly. Demand for HIV-related care fell even more rapidly. The rise in outpatient care demand seen in the developed world did not occur in this setting. |
| WePE0086 | PRELIMINARY OUTCOMES OF PATIENTS RECEIVING SUPERVISED ANTIRETROVIRAL THERAPY IN RURAL RWANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0086 H.M. Epino1, A. Karamaga1, P.C. Niyigena1, W. Nagaba1, Y. Uwimana1, S.N. Stulac1, C.D. Mitnick2, J.S. Mukherjee3, P.E. Farmer3, M.L. Rich3 Ambulatory delivery of ART in rural poor communities in Africa is feasible. Accompagnateurs can assure the delivery of therapy with excellent adherence and patient follow up. The model of care, which includes nutritional support, can result in rapid weight gain and improved immunological status among patients receiving ART. |
| WePE0087 | CAN ROUTINE ALANINE TRANSAMINASE (ALT) MONITORING BE SIMPLIFIED IN PATIENTS STARTING A NEVIRAPINE CONTAINING ANTIRETROVIRAL TREATMENT REGIMEN? AN EXPERIENCE FROM A CLINIC SETTING IN MAPUTO, MOZAMBIQUE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0087 S. Mikusova1, M. Biot1, R. Bastos2, R.C. Manuel2, N.A. Ramanlal1, M. Stefanutto1, P. Firmenich3 It is justified to perform routine ALT measurements at baseline and 0.5M in specific risk-groups such as pregnant women, patients on hepatotoxic medication or those symptomatic for liver dysfunction. In all other patients, it would be acceptable to drop "systematic" ALT measurements at baseline and at M0.5. |
| WePE0088 | INTEGRATING FAMILY AND COMMUNITY SUPPORT EFFORTS IN ART PROGRAMS IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0088 L. Nakato The major source of information and support for ART is the health facilities, which are very limited in resource poor settings like Uganda. This affects patients' capacity to adhere. It is therefore important that ART Programs build the capacity of the readily available resource of family and community support for ART Programs to succeed. |
| WePE0089 | OUTCOMES OF HIV-INFECTED ORPHANED AND NON-ORPHANED CHILDREN ON ANTIRETROVIRAL THERAPY IN WESTERN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0089 W. Nyandiko-Mokaya1, S. Ayaya1, E. Nabakwe1, C. Yiannoutsos2, K.W. Kaloustian3 Good adherence is possible in western rural Kenya. antiretroviral therapy for HIV-infected children produced substantial and sustainable improvement of CD4%. Orphan status was not associated with worse short-term outcomes. |
| WePE0090 | A HIGH PERCENTAGE OF ANTIRETROVIRAL TREATMENT (ART) EXPERIENCED PATIENTS ENROLLED IN A HIV TREATMENT PROGRAM IN LAGOS, NIGERIA: A COMPARISON OF THE VIROLOGICAL AND IMMUNOLOGICAL OUTCOMES OF ARV-NAÏVE AND ARV-EXPERIENCED PATIENTS ON 2003 WHO RECOMMENDED FIRST LINE ART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0090 J. Wenkel1, D. O'brien2, W. van den Boogaard3, E. Botha Standaert1, K. Braker4, M.A. Olaiya5, G. Guenther6, A.G. Grillo1, B.A. Olomo1, C. Mills7 The outcomes for ART experienced patients were inferior to those of naïve patients. Results for VL > 10.000 and CD4 decrease below baseline suggest a high proportion of therapy failure in the experienced group. This has implications for programs using these regimens for ART experienced patients. |
| WePE0091 | DETECTABLE VIRAL LOADS AFTER 6 MONTHS OF TREATMENT THROUGH THE NATIONAL HAART PROGRAM IN PERU: FREQUENCY AND ASSOCIATED FACTORS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0091 D. Lopez de Castilla1, K. Verdonck2, C. Seas1, M. Campos1, D. Iglesias1, E. Gonzalez1, C. Maguiña1, E. Gotuzzo1, J. Echevarria1 Uncontrolled use of ARV before the implementation of the NP might have led to primary and secondary resistance and could explain the association with incomplete viral suppression. NNRTI-containing HAART regimens should be re-assessed in these settings. |
| WePE0092 | THE ROLL-OUT OF HIV TREATMENT IN PERU: APPLYING THE DOTS-PLUS MODEL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0092 J.L. Sebastian1, M. Munoz2, E. Palacios2, B. Espiritu2, L. Mestanza2, K. Chalco2, K. Llaro2, D. Guerra2, S. Shin3, J. Bayona2 The experience of DOTS-Plus expansion, the collaborative support of an agile NGO, and the firm political commitment of the Peruvian HIV Program were the main strengths that enabled the successful scale-up of the HIV program. |
| WePE0093 | IMPLEMENTING AN ELECTRONIC MEDICAL RECORD SYSTEM TO EXPAND ARV TREATMENT IN RURAL RWANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0093 P. Manyika1, D. Jazayeri2, M. Rich1, N. Lesh1, H. Fraser3, C. Allen1 This project and others in Haiti, Peru, Malawi, Kenya and elsewhere have shown that clinically-focused EMR systems are feasible and useful to support scale-up of HIV treatment projects to hundreds or thousands of patients. |
| WePE0094 | THE EFFECT OF TENOFOVIR+DIDANOSINE CONTAINING REGIMENS ON CD4 COUNTS IN TREATMENT-EXPERIENCED PATIENTS AT THE MILDMAY CENTRE, UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0094 L.K. Nabiddo1, B. Wilson2, T.J. Rukirande1 Patients on TDF+low-dose ddI containing regimens at The Mildmay Centre have experienced significant improvements in CD4 counts, providing early evidence that this regimen may be effective as second-line therapy in resourcelimited settings. |
| WePE0095 | THE IMPACT OF NURSES IN THE PROVISION HAART IN A POOR URBAN SETTING IN HAITI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0095 E. Michel, P. Leger, P. Severe, M. Charles, J. Julmiste, J. Borgart, J.W. Pape In countries with limited resources in medical personnel, Nurse Practitioners can play a significant role in the scale-up of ART programs. |
| WePE0096 | UPDATE ON THE EFFECTIVENESS OF INDIA'S ANTIRETROVIRAL TREATMENT (ART) PROGRAMME Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0096 A. Khera1, N.S. Dharamshaktu1, B.B. Rewari1, J.-M. Tassie2, P. Chan3, B. Mahanty3 The analysis showed high rates of treatment continuation and survival. The lower proportion of women enrolled in ART may be related to the HIV/AIDS epidemic profile. As expected, deaths occurred mainly during the first 6 months and decreased thereafter. Survival of women on treatment is slightly better than of men. Most patients remain on first line regimen at 6 and 12 months. The effectiveness and quality of the ART programme forms the basis for further expansion and decentralization of ART services in the country. |
| WePE0097 | LIFE EXPECTANCY OF HIV-INFECTED MEN AND WOMEN INITIATING HAART IN RESOURCE-CONSTRAINED SETTINGS: INSIGHTS FROM THE ART-LINC COLLABORATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0097 R.S. Hogg1, P. Braitstein2, R. Weigle3, N. Kumarasamy4, T. Meade5, D. Nash6, D.R. Bangsberg7, M. Schechter8, E. Sprinz9, J.E. Sidle10, L. Pepper11, E. Balestre12, M. Brinkhof2, M. Egger2, F. Dabis12, ART-LINC Collaboration These data suggest that in spite of HAART use and under-ascertainment of mortality, life expectancy appears lower in these resource-constrained settings compared to HIV-infected adults receiving HAART in Canada. This may be related to factors not related to HAART use. |
| WePE0098 | SHORT-TERM CLINICAL AND IMMUNO-VIROLOGICAL OUTCOMES OF NNRTI-BASED HAART USING GENERIC DRUGS IN A PERUVIAN COHORT OF HIV-INFECTED PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0098 J.A. Collins, J. Claros, C. Rojas, L. Hercilla This study show a high overall effectiveness of NNRTI-based HAART using generic drugs in spite of high proportion of patients with AIDS-defining diseases, advanced HIV infection, and high viral load. |
| WePE0099 | EFFICACY AND TOLERABILITY OF NEVIRAPINE-BASED REGIMEN VS EFAVIRENZ-BASED REGIMEN IN HIV-INFECTED THAI CHILDREN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0099 K. Lapphra, N. Vanprapar, S. Chearskul, W. Phongsamart, P. Chearskul, W. Prasitsuebsai, K. Chokephaibulkit NNRTI-based HAART were effective in children in developing countries at least for 3 years. |
| WePE0100 | COMPARING CLINICAL VERSUS IMMUNOLOGICAL AND VIROLOGICAL RESPONSES TO HAART IN HIV-INFECTED UGANDAN CHILDREN ON TRIOMUNE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0100 P. Ajuna1, M. Mubiru1, L. Barlow -Mosha1, M. Luttajumwa1, B. Musoke1, M.G. Nalubega1, M. Namawejje1, R. Kayondo1, M. Owor1, D. Bagenda2, P. Musoke3 Growth monitoring of children on HAART in resource limited settings may be a useful tool to determine response to therapy, in addition to measurements of immunological indices. |
| WePE0101 | INCREASED TRANSFER OF KNOWLEDGE THROUGH HIV/AIDS TELEMEDICINE CASE CONFERENCE: ADDIS ABABA, ETHIOPIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0101 Y. Abebe1, M. Doherty2, S. Dawd3, A. Getachew4, J.G. Bartlett5 The telemedicine case conference demonstrates the effectiveness of internet-based learning in resource limited countries. Ethiopia is in the process of creating a virtual network via satellite stations throughout the country. PEPFAR implementers can harness this potential to create HIV/AIDS distance learning modules with the goal of increased clinician retention, worker satisfaction, and improved quality of care. Formal evaluation of clinicians involved in telemedicine is planned in the future. |
| WePE0102 | EVALUATION OF THE CHANGES IN HAEMATOLOGICAL PARAMETERS OF 500 CHILDREN ON ANTIRETROVIRAL MEDICATION. EXPERIENCE FROM PIETERMARITZBURG, KWA- ZULUNATAL, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0102 K. Naidoo1, M. Krishna2, M. Suleman1, M. Bizaare1, N. McKerrow1, H. Hurkchand3 Despite the high levels of background anaemia in this population the addition of antiretroviral treatment brings an overall improvement in anaemia. This occurs with the significant improvement in immune status and virological response. |
| WePE0103 | DIVERGENT VIEWS REGARDING ADHERENCE TO ANTIRETROVIRAL THERAPY BETWEEN CLINICIANS AND THEIR PATIENTS IN DALI, YUNNAN PROVINCE, CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0103 C. Gill1, D. Hamer1, M. Bachman-DeSilva1, K. Heggenhougen1, K. Xu2, Y. Yuan3, W. Fan3, L. Sabin1 It is likely that non-adherence is far more common in China than many clinical staff believe. There is also a large gap between what patients and clinicians believe to be important barriers to adherence. |
| WePE0104 | RESPONSE TO HIGHLY ACTIVE ANTIRETROVIRAL THERAPY AMONG PATIENTS WITH CD4 COUNTS BELOW 50 CELLS/MM3 IN A RESOURCECONSTRAINED SETTING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0104 R. Wiseman, N. Padayatchi, H. Carrara, K. Naidoo, A. Singh, G. Nair, M. Khan, S. Abdool Karim The risk of death for patients with CD4<50 was RR 8 (95% CI 1.5 – 42.7) compared to the CD4>100 group. Among the 8 deaths, 6 patients died within the first 2 months of therapy. It is likely that these patients presented too late for treatment and never underwent complete immune reconstitution. Among the survivors, fewer patients in the CD4<50 group achieved viral suppression at 6 months [RR 0.7 (0.5 – 0.8)]. These findings highlight the importance of identifying AIDS patients at an earlier stage of disease with CD4 counts greater than 100 for initiation of HAART. |
| WePE0105 | TREATMENT WITH HAART OF ADULTS WITH BASELINE CD4 CELL COUNT < 25/μL IN THE PUBLIC SECTOR IN SOWETO, SOUTH AFRICA: 48 – WEEK RESULTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0105 A. Karstaedt The antiretroviral response in this advanced cohort in a crowded public sector setting was adequate and was not significantly different from that of the CD4>140/ml group. The high early mortality in the advanced cohort was the main difference between the 2 groups. |
| WePE0106 | SURVIVAL OF HIV-INFECTED PATIENTS IN NORTH OF THAILAND ENROLLED IN NATIONAL ANTIRETROVIRAL PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0106 S. Chaiyamahapurk Survival probability at one year was not different from other studies in developing countries, however it was poorer when it was compared with studies from developed countries. CD4 cell count was the strong predictor of survival. Low body weight at starting ARV was also strongly associated with increased mortality an its effect was more significant in group of low CD4 cell count. |
| WePE0107 | FOUR YEAR SURVIVAL IN THE HEINEKEN WORKPLACE HAART PROGRAMME IN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0107 S. Van der Borght1, H. Rijckborst1, D. Biteziminsi2, P. Clevenbergh3, Heineken African Medical Staff Investing in quality of treatment programs contributes to the realisation of a good medium term result. Survival rates of more than 90% over four years are possible. |
| WePE0108 | ARAMIS: A FRENCH OBSERVATIONAL PROSPECTIVE STUDY OF PATIENTS RECEIVING A ONCE DAILY ANTIRETROVIRAL REGIMEN. DATA ANALYSIS AT TWELVE MONTHS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0108 R. Landman1, Y. Mouton2, I. Ravaux3, P. De Truchis4 This interim analysis confirms the efficacy of QD regimen, especially for a 2 NRTIs + NNRTI combination and pts satisfaction. The 2-years results will assess the potential long-term benefit of this therapeutic approach. |
| WePE0109 | USING BIOMETRIC SMART CARDS TO TRACK PATIENTS ON ART IN SOUTH AFRICA: STAT™, A TECHNOLOGY SOLUTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0109 R. Bayard1, J. Wilson1, R. Ainsworth2, J. Mboyane2, J. Stanton3 Biometrics/smart card technology can provide a solution for the extensive information needs of expanding ART services. Private partnerships should be explored as options to make technology financially sustainable in resource-poor settings. |
| WePE0110 | LONG-TERM EFFICACY AND SAFETY OF ONCE-DAILY RITONAVIR BOOSTED-SAQUINAVIR MESYLATE (SQV/R) PLUS 2 NRTIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0110 J. Ananworanich1, A. Gayet-Ageron2, B. Hirschel2, M. Le Braz2, P. Chetchotisakd3, W. Prasithsirikul4, S. Kiertiburanakul5, W. Munsakul6, P. Raksakulkarn7, S. Tansuphasawadikul8, T. Jupimai9, S. Ubolyam9, M. Schutz10, K. Ruxrungtham11, Staccato Study Group SQV-HGC/r 500mg with TDF/FTC provides a convenient and effective first line regimen of 4 to 5 pills taken OD. In Western patients this regimen is being studied with the 2000 mg dose of SQV plus TDF/FTC due to higher body weight. |
| WePE0111 | ANTIRETROVIRAL THERAPY FOR HIV-INFECTED CHILDREN IN UGANDA, 2004 – 05 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0111 E. Luyirika1, T. Finkbeiner2, L. Nabiddo1, E. Kikule1, K. Kasule1, J. Floyd3, J. Downing1, M. Earp2, S. Shinde2, A. Namale4, R. Nakityo4, D. Okullo4, J. Mermin4, N. Shaffer2, J.T. Brooks2 In this specialized program, pediatric ART was effective and well tolerated. Mortality was low, clinical and laboratory parameters improved, and most children stayed on their initial ART regimen. Scale-up of pediatric ART programs should be encouraged, although longer term follow-up data are needed. |
| WePE0112 | LOW PREVALENCE OF DETECTABLE VIRAL LOAD IN COHORTS OF PATIENTS RECEIVING ART IN PUBLIC HOSPITALS AND COMMUNITY-BASED ORGANIZATIONS (CBOS) IN UNDER-RESOURCED SETTINGS IN BURKINA FASO AND MALI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0112 H.A. Traoré1, S. Ag-Aboubacrine1, A. Sylla2, S. Koala3, P. Niamba4, J. Drabo5, M. Maïga6, A. Ouermi7, S. Rashed8, M.V. Zunzunegui8, C. Boileau8, M. Sylla9, C. Tremblay10, V.-K. Nguyen8, Pro-ARV Group This study suggests that adherence rates early on in treatment compare favourably with structured clinical trials conducted in well-resourced settings. Lack of differences between sites even though these had different approaches suggest that site-specific factors do not drive adherence rates. Further study is required to ascertain the sustainability of these adherence rates. |
| WePE0113 | SECOND LINE TREATMENT IN LILONGWE MALAWI: ASSESSMENT OF THOSE IN NEED Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0113 M. Hosseinipour1, P. Ingiliz2, C. Kanyama1, R. Weigel3, D. Mzinganjira1, K. Schaalman1, E. Mhango3, S. Phiri3 ART patients will need PI based treatment for both 1st line toxicity and failure. Programs should calculate 2nd line drug needs considering both criteria. CD4 decline of >30% for the identification of treatment failure, without confirmatory HIVRNA, may result in false positives with premature modification of ART. Combined immunologic and clinical criteria may yield a more specific diagnosis for failure. |
| WePE0114 | COMPREHENSIVE HIV CARE INCLUDING ANTIRETROVIRAL THERAPY IN SOUTHERN UKRAINE: THE CHALLENGES, RESULTS AND LESSONS LEARNED FOR THE FUTURE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0114 A. Telnov1, G. van den Berk2, S. Venis3, J. Reinartz3, Z. Islam3, J. van der Meer4, R. Bedell5, D. O' Brien3 ART can be successfully provided in Ukraine, including to those with a history of IDU, with excellent clinical and immunological outcomes. This has acted as a catalyst for increased access to ART in the Ukraine. |
| WePE0115 | CLINICAL, IMMUNOLOGIC, VIROLOGIC AND ADHERENCE OUTCOMES IN THE SENEGALESE HIV-1 COHORT AFTER 7 YEARS OF TREATMENT WITH HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0115 P.S. Sow, The Senegalese Initiatve on Access to ARVs (ISAARV) To evaluate the long term effectiveness of HAART in one of the oldest cohorts of HIV-1 infected persons in Africa (N=404) by analysis of adherence, clinical, immunologic and virologic outcomes, and emergence of drug resistance. |
| WePE0116 | ART - MORE THAN JUST ARVS: LESSONS LEARNT FROM RAPID START-UP OF ART SERVICES AT THE SECONDARY LEVEL IN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0116 B. Keshinro1, M. Ibrahim1, L. Stuart2, Y.D. Mukadi2, P. Lamptey2 ART start up and scale up to secondary health facilities as a strategy for increasing access to ART should engage Government, health facility staff and the communities from conception to achieve rapid, sustainable results. |
| WePE0117 | OUTCOMES OF A PAEDIATRIC HIGHLY ACTIVE ANTIRETROVIRAL THERAPY COHORT FROM KWAZULU-NATAL, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0117 A. Reddi1, S. Leeper2, A. Grobler3, H. France1, G. Dorse1, H. Coovadia4, J. Giddy1 This report suggests that paediatric HAART in sub-Saharan Africa can be effective and sustainable despite the challenges of a resource-limited setting. |
| WePE0118 | THE EFFECTIVENESS OF PUBLIC SECTOR ANTIRETROVIRAL TREATMENT (ART) IN THE FREE STATE PROVINCE, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0118 L. Fairall1, M. Bachmann2, C. van Vuuren3, G. Louwagie4, D. Steyn3, R. Nhiwatiwa3, P. Chikobvu5, B. Andrew6, C. Seebregts7, V. Timmerman7, M. Msimanga7, G. Rembe1, C. Lombard8, E. Bateman1, M. Zwarenstein9, F. Booysen10, M. Tshabalala11, P. Shai-Mhatu12, R. Chapman13 ART appears as effective in the Free State public sector programme as under more optimal circumstances. The unusually high survival in this treatment cohort may be due to selection bias in this setting. |
| WePE0119 | THE NATIONAL ANTIRETROVIRAL THERAPY (MASA) PROGRAM IN BOTSWANA: FOUR YEARS AND 50,000 PATIENTS ON TREATMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0119 J. Puvimanasinghe1, S. Ramotlhwa1, T. Steen1, N. Ndwapi2, T. Gaolathe2, T. Fantan3, R. Marlink4, K. Seipone1, L. Mazhani5 Trained personnel and other resources need to be increased and ART services need to be further decentralized. Policy issues regarding purchase of generic drugs and authorization of other categories of health staff to initiate and dispense treatment need to be revisited. Collaboration with development partners, the private sector and civil society should be strengthened further. |
| WePE0120 | COMPREHENSIVE CARE OF HIV-INFECTED ADOLESCENTS IN SUB-SAHARAN AFRICA: MONITORING GROWTH, DEVELOPMENT AND RECOVERY WHILE ON ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0120 S. Bakeera-Kitaka1, M. McKellar2, C. Snider3, A. Kekitiinwa1, T. Piloya4, J.-M. Matovu4, E. Katabira5, M. Sande5, A. Ronald5 HAART in this sub-Saharan setting can be effective in HIV-infected adolescents and is able to restore some measures of growth and development. |
| WePE0121 | LONG - TERM EFFICACY, SAFETY, AND TOLERABILITY OF INDINAVIR-BASED THERAPY IN NUCLEOSIDE EXPERIENCED HIV-1-INFECTED PATIENTS IN A RESOURCE LIMITED SETTING: 272 WEEKS FOLLOW UP OF HIV-NAT 005 STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0121 A. Avihingsanon1, S. Kerr2, M. Boyd3, C. Ungsedhapand1, C. Duncombe4, S. Ubolyam1, K. Pussadee1, K. Ruxrungtham5, J. Lange6, D. Cooper7, P. Phanuphak8, HIV-NAT 006 Study Team In this group of patients with advance HIV disease in a RLS, IDV provided potent and durable viral suppression and immunological recovery. High incidence of renal and GI toxicity may be associated with Asian ethnic and low BMI. A dose reduction improved the regimen tolerability while maintaining efficacy. |
| WePE0122 | ASSESSING PROGRAM CONTINUATION RATES THROUGH LIFE TABLE ANALYSIS - AN INNOVATIVE APPLICATION FOR RESOURCE-LIMITED PROGRAM SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0122 I. Wanyeki1, J. Fielder2, K. Foreit3 Program retention, especially in the first months after initiating treatment, is an important indicator of quality of care. Life table analysis of existing data is inexpensive and findings can quickly alert program managers to issues needing further attention. The finding that women at the facility analyzed were more likely to discontinue treatment is a call for action to determine the causes of the sex difference. |
| WePE0123 | 12-MONTH OUTCOMES AMONG HIV-INFECTED INDIVIDUALS STARTING ANTIRETROVIRAL THERAPY IN SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0123 S. Charalambous1, K. Fielding2, A. Stenson1, L. Pemba1, C. Innes1, S. Senoge1, P. Seatlanyane1, R. Wood3, D. Martin3, A. Grant2, G. Churchyard1 Failure of virological suppression at 6 weeks is a useful determinant of later outcomes and where available may be an appropriate point for intensive adherence interventions. Site factors are important in determining the response to treatment. |
| WePE0124 | RISK FACTORS FOR DEATH AFTER ART INITIATION IN POOR SETTING COUNTRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0124 P. Leger, P. Severe, J. Julmiste, M. Theliard, M. Charles, E. Michel, J. Davilmar, P. Vachon, J.W. Pape |
| WePE0125 | EFFICACY OF MDOT AT IMPROVING VIROLOGICAL OUTCOME AMONG PATIENTS TAKING HAART IN COMMUNITY AND HOSPITAL BASED COHORTS IN MALI AND BURKINA FASO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0125 S. Ag Aboubacrine1, C. Boileau2, A. Sylla3, S. Koala4, P. Niamba5, J. Drabo6, M. Maïga7, A. Ouermi8, S. Rashed9, M.-V. Zunzunegui2, M. Sylla10, C. Tremblay11, V.-K. Nguyen2, Pro-ARV Group Prevalence of resistance in treated patients with VL>500 was high and compromised efficacy of the intervention. Even in non-resistant patients mDOT had limited success. Access to viral load testing needs to be expanded to ensure early detection of non-adherent patients and treatment sites need to be adequately resourced to support adherence in order to ensure treatment sustainability. |
| WePE0126 | HIV CARE CLINICS AS A PLATFORM FOR RAPID SCALE UP OF ART PROGRAMS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0126 F. Miruka1, B. Marston2, N. Lennah3, J. Gesami3, J. Otieno4, J. Wariero4, P. Oguta5, M. Aluoch5, L. Ngere1, A. Ajwang1, K. Decock6 The overwhelming need for HIV care and treatment services in Nyanza Province requires continued scale up to bridge the gap between the number of patients on and the actual number of patients, particularly children, who are in need of ART. |
| WePE0127 | REACHING THE POOR - CHANGES OF PATIENTS' CHARACTERISTICS AFTER INTRODUCTION OF FREE ARV AT THE LIGHTHOUSE AT KAMUZU CENTRAL HOSPITAL, LILONGWE, MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0127 E. Mhango1, S. Phiri1, M. Boxshall1, M. Hochgesang2, M. Hosseinipour3, J. Chiwoko1, A. Harries4, R. Weigel1 Introduction of free ARV and access to more clinics were associated with increased proportion of females, younger patients, sicker patients, and poorer patients accessing ARV, as well as decreased loss to follow-up. |
| WePE0128 | RAPID SCALE UP OF ANTIRETROVIRAL THERAPY WITH HEALTH WORKER HIV TRAINING AND CAPACITY BUILDING, HUBEI PROVINCE, CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0128 F. Zhan1, C. Teter2, X. Gui3, P. Liu4, R. Sherer2 Rapid scale-up of ART using existing HCW capacity and TOT trainings is achievable in Hubei Province. Resident US expertise supporting Chinese physicians & trainers, active CDC participation and leadership from an HIV Center of Excellence with a renowned Chinese expert (GX) are essential. |
| WePE0129 | OVERCOMING PROBLEMS WITH REGARDS TO PAEDIATRIC ADMINISTRATION &I#8211; DISADVANTAGES OF USING ORAL LIQUID FORMULATIONS AND THE RECOMMENDATIONS OF THE PERINATAL HIV RESEARCH UNIT (PHRU) PHARMACY, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0129 F. Mayat Methods have been developed by staff to improve administration accuracy and to help illiterate caregivers. These include early formulation changes to solid dosage forms, syringe and dosage aids, pictograms and blister packs .Other methods and tools used to improve compliance include fieldworker checks, adherence percentage records and mandatory support/couselling sessions. Patient preference and even disclosure issues must always be considered when prescribing paediatric ARV's (pictures and samples will be included in presentation). |
| WePE0130 | ANTIRETROVIRAL DURABILITY AND TOLERABILITY IN HIV-INFECTED ADULTS LIVING IN URBAN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0130 C. Hawkins1, C. Achenbach1, W. Fryda2, D. Ngare3, R. Murphy1 Excellent clinical and immunologic responses were seen in those on ARVs. Patients with poor baseline immune status require close monitoring for ARV response and laboratory toxicity. Initial NNRTI-based ARV regimens appear to be durable with a low number of treatment failures in this urban Kenyan population. |
| WePE0131 | EVALUATION OF TREATMENT OUTCOMES AND ADHERENCE AMONG PATIENTS RECEIVING ANTIRETROVIRAL THERAPY IN THE CONFLICTAFFECTED REGION OF NORTH UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0131 A. Rigon1, B. Nattabi2, B. Pido2, C. Pierotti3, L. Ojom3, F. Ciantia3, M. Fabiani4, S. Declich4, G. Gandolfo5, D. D'avola1, G. Mottini1, Z. Yoti6, R. Ocakacon2 The results show a good immunological and virological response and a strict adherence to ART, thus suggesting that ART can be successfully implemented in a region affected by civil strife and all related logistical problems. |
| WePE0132 | CLINICAL PRACTICES IMPACTING THE DURABILITY OF HAART IN RESOURCE-LIMITED SETTINGS: A FIVE-YEAR SOUTH AFRICAN MANAGED HEALTHCARE STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0132 D. Sifris, A. van Bassen, J. Myhre In the absence of genotyping, many doctors are changing HAART prematurely based on presumptive, unmotivated evidence, which correlates directly to a reduction of HAART durability. Paradoxically, treater experience does not reduce the incidence of this, with many failing to address adherence, abandoning endorsed protocols, and frequently succumbing to "drug fashion." |
| WePE0133 | MECHANISM OF CD4+ T CELL DEPLETION IN PATIENTS EXPOSED TO TENOFOVIR PLUS DIDANOSINE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0133 C. de Mendoza1, J.M. Benito1, N. Zahonero1, A. Cascajero1, M. de Baar2, P. Barreiro1, J. Gonzalez-Lahoz1, V. Soriano1 Treatment with ddI+TDF is associated with a progressive loss of CD4+ T cells despite complete viral suppression. This deleterious effect does not seem to be mediated by enhanced mitochondrial toxicity in PBMC. Our results suggest that increased apoptosis could lead to loss of CD4+ T cells in TDF+ddI treated patients. |
| WePE0134 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0134 Abstract not available. |
| WePE0135 | THE EFFECTIVENESS OF A DEDICATED SERVICE FOR MANAGING LIPODYSTROPHY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0135 L. Ratcliffe, P. Lewthwaite, E.G.L. Wilkins The majority of patients were referred because of facial LA for consideration for NewFill. 30% were still on a thymidine drug and many had evidence of the metabolic syndrome. The Lipodystrophy clinic allowed collection of BL assessments, cardiovascular risk factor-reducing advice, ARV switch, and advice on metabolic management to be given as well as facilitating recruitment to clinical studies. |
| WePE0136 | LONGITUDINAL INCREASES IN WAIST CIRCUMFERENCE ARE ASSOCIATED WITH HIV-SEROSTATUS, INDEPENDENT OF ANTIRETROVIRAL THERAPY IN THE MULTICENTER AIDS COHORT STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0136 T. Brown1, Z. Wang2, H. Chu2, F. Palella3, L. Kingsley4, M. Witt5, A. Dobs2 Cumulative NRTI therapy was associated with longitudinal decreases in body circumference measurements, whereas HIV infection was associated with increases in waist circumference independent of ART. |
| WePE0137 | A NOVEL ACTIVE SITE MUTATION OF HUMAN DNA POLYMERASE G ASSOCIATED WITH NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR (NRTI)-INDUCED MITOCHONDRIAL TOXICITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0137 H. Yamanaka1, H. Gatanaga1, K. Pope2, S. Mastuoka1, S. Kimura1, S. Oka1 A novel active site mutation of POLGα was identified, which reduced the polymerase activity of POLGα and was associated with NRTI-induced mitochondrial toxicities. |
| WePE0138 | EFFECT OF LOW DOSE SALMON OIL (SO) WITH OR WITHOUT LIPID LOWERING MEDICATION (LLM) ON TRIGLYCERIDES AND TC/HDL RATIO IN HAART TREATED HIV+ PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0138 J. Baril1, C. Kovacs2, S. Trottier3, G. Roederer4, A. Martel5, N. Ackad6, N. Longo7, C. Liao7, J. Sampalis7 Salmon oil is well-tolerated and effective in reducing serum triglycerides in patients receiving HAART. SO has a significant additive effect over and above that of LLMs. |
| WePE0139 | ALTERATIONS OF ANTHROPOMETRIC AND METABOLIC PARAMETERS CORRELATE WITH EARLY INCREASE IN IFN-γ AND TNF-Iα PRODUCTION AFTER STARTING ANTIRETROVIRAL TREATMENT IN ART-NAÏVE HIV PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0139 A. Biglino1, M.T. Brusa2, C. Bolla2, C. Martini3, E. Concialdi2, M. Mascolo4, G. Raineri4, M. Gobber5 In ART-naïve patients , early increase in IFN-γ and TNF-α after starting HAART is associated with insulin resistance, raised triglyceride plasma levels, and increase of WHR and BMI indexes. |
| WePE0140 | HOW COMMON IS LIPODYSTROPHY AFTER AT LEAST 1 YEAR OF WHO FIRST LINE ANTIRETROVIRAL TREATMENT IN KIGALI, RWANDA? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0140 J. van Griensven1, L. De Naeyer1, T. Mushi2, S. Obarijoro3, C. Gazille1, R. Zachariah1 This is the first study reporting prevalence data on lipodystrophy in Africa, revealing it as a frequent complication of HAART containing d4T. Simple tools to detect lipodystrophy will have to be validated in an African population. Therapeutic and preventive strategies such as NRTI switch and adjustment of first line HAART need to be assessed urgently, as well as the impact of this syndrome on adherence and soical stigmatisation. |
| WePE0141 | TOXICITY OF COMBINATION NRTI REGIMENS IN TREATMENT OF PEDIATRIC HIV INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0141 P.L. Williams1, L. Wang1, R. Van Dyke2, and the PACTG 219C Study Team ZDV-containing dual NRTI regimens had lower rates of target toxicities than those including d4T. However, ddI/d4T has an acceptable safety profile as a dual NRTI backbone in children and may be appropriate for inclusion in a second-line therapeutic regimen. |
| WePE0142 | TRANSGENIC CARDIAC TARGETING OF A POINT MUTATION OF MITOCHONDRIAL THYMIDINE KINASE (TK2): RELATIONSHIP TO MITOCHONDRIAL TOXICITY IN HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0142 S. Hosseini1, J. Kohler2, C. Haase2, T. Ludaway2, J. McNaught2, R. Russ2, E. Green2, N. Tioleco2, E. Keebaugh2, W. Lewis2 Over-expression of a point mutant of TK2 targeted to the heart and treated with HAART results in ultrastructural and function changes that relates mechanistically to mitochondrial toxicity. |
| WePE0143 | LONG-TERM CHANGES IN BODY COMPOSITION AMONG HIV-INFECTED ANTIRETROVIRAL NAÏVE PERSONS RANDOMIZED TO PI VS. NNRTI VS. PI + NNRTI-BASED ANTIRETROVIRAL REGIMENS: RESULTS OF THE CPCRA 061 METABOLIC STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0143 C.L. Gibert1, J.C. Shlay2, G. Bartsch3, G. Peng3, J. Wang4, F. Visnergarwala5, S. Raghavan6, Y. Xiang3, M. Farrough7, H.E. Perry8, C. Grunfeld9, W.M. El-Sadr6, for the Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) In this prospective trial, changes in total and regional body fat did not differ by ART strategy, with losses demonstrated in STAs and gains in FFM, NSTAs, and VTA. In contradistinction to other studies, there was no significant difference by planned ART. |
| WePE0144 | INSULIN RESISTANCE AND RELATION TO INCREASED PLASMA LACTATE PRODUCTION AFTER SUBANAEROBIC EXERCISE IN HIV-1-INFECTED PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0144 A. Maagaard1, P.A. Torjesen2, J.N. Bruun1 Lactate production after subanaerobic exercise in both HIV-infected groups may reveal dysfunctional mitochondria caused not only by NRTIs but also HIV-infection per se. Insulin resistance was not related to these observations. |
| WePE0145 | HIV AND METABOLIC SYNDROME (MET-SYN): CHARACTERISTICS OF PATIENTS AND LIMITATIONS OF CURRENT DIAGNOSTIC CLASSIFICATIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0145 J. Falutz1, L. Rosenthall2 The overall prevalence of patients with Met-Syn, 47%, was higher than in historical HIV(-) controls (20 - 25%). No single classification identified patients with greater insulin resistance or trunk fat measurements, the abnormalities most associated with Met-Syn pathogenesis. The lack of agreement between different Met-Syn classifications in identifying patients at higher risk for CVD suggests further research is needed to achieve consensus on using this important diagnostic tool. |
| WePE0146 | HIGH PREVALENCE OF REDUCED BONE MINERAL DENSITY IN HIV POSITIVE INDIVIDUALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0146 S. Guillemi1, F. Ng2, R. Joy2, C. Rocha2, M. Harris2, G. Bondy2, A. Beltberg3, J. Montaner2 We found a 61% prevalence of abnormal BMD by DEXA scan in an unselected group of HIV+ individuals. Abnormal BMD was associated with lower body weight, and lower CD4 count but not with HAART use or AIDS stage. |
| WePE0147 | PREVALENCE AND PREDICTORS OF METABOLIC SYNDROME AMONG HIV-POSITIVE AND NEGATIVE WOMEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0147 M.E. Sobieszczyk1, D.R. Hoover2, K. Anastos3, K. Mulligan4, T. Tan5, C. Hyman6, M.H. Cohen7, S.R. Cole8, J. Justman9, Women's Interagency HIV Study Metabolic syndrome is more prevalent in HIV-infected than HIV-uninfected women. Increased prevalence is associated with older age and other traditional risk factors in both groups. For HIV-infected women, higher HIV viral load levels and use of stavudine were associated with an increased prevalence of metabolic syndrome. |
| WePE0148 | SIGNIFICANT CORRELATION OF LOWER MITOCHONDRIAL DNA CONTENT IN PERIPHERAL BLOOD MONONUCLEAR CELLS WITH LOWER LIMB FAT MASS AND LIPODYSTROPHY IN STUDY 903 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0148 M.P. de Baar1, B. Lu2, D.J. McColl2, H. van Schijndel1, M. van Schilfgaarde1, M.D. Miller2 Significantly lower mtDNA levels were measured in PBMC from patients that developed lipodystrophy through 144 weeks in study 903. Lower total limb fat mass correlated strongly with d4T treatment and also with lower mtDNA levels in PBMC. Together, these results suggest that mtDNA levels in PBMC reflect changes in adipose tissue and might be a useful, low-cost marker in the diagnosis of lipodystrophy. |
| WePE0149 | EVOLUTION OF HEMATOLOGIC PARAMETERS IN THAI HIV-INFECTED PREGNANT WOMEN INITIATING ZIDOVUDINE PROPHYLAXIS AT 28 WEEKS´ OR 35 WEEKS GESTATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0149 N. Briand1, S. Le Coeur2, G. Jourdain3, J. Achalapong4, C. Putiyanun5, S. Techapalokul6, N. Chotivanich7, K. McIntosh8, M. Lallemant9, Program for HIV Prevention and Treatment study group ZDV initiation at 28 rather than 35 weeks´ gestation depresses hematologic parameters slightly. By the time of delivery this adverse impact appears to be largely reversed. The mechanism of this catch-up recovery deserves further investigation. |
| WePE0150 | CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH SYMPTOMATIC HYPERLACTATEMIA, ON A FIRST-LINE ANTIRETROVIRAL REGIMEN OF STAVUDINE, LAMIVUDINE AND NEVIRAPINE (D4T/3TC/NVP) IN AN URBAN DISTRICT HOSPITAL SETTING IN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0150 D.K. Kimani1, F. Filén2, M. Nderitu1, I. Van Engelgem2, A. Suleh1, R. Zachariah3 Scaling-up ART with limited laboratory support, will require clinicians to keep a high index of suspicion for symptomatic hyperlactatemia to avoid associated deaths. |
| WePE0151 | TRI-ACETYL-URIDINE (TAU) SUBSTITUTION IN ANTIRETROVIRAL-TREATED HIV-INFECTED PATIENTS WITH LIPODYSTROPHY AND POLYNEUROPATHY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0151 T. Sternfeld1, R. Winzer2, S. Mudra1, A. Tischleder1, C. Hoepfner1, B. Sporer3, R. Paul3, E. Zankl4, S. Schwarze5, G. Ader6, A. Knopf7, P. Langmann2, H. Klinker2, F.-D. Goebel1, J.R. Bogner1, German Competence Network HIV/AIDS TAU in a dosage of 500 mg bid increased plasma uridine levels significantly and was well tolerated. Subjective patient's scores for lipodystrophy and polyneuropathy as well as nerve velocity conducting studies showed improvement of symptoms. This is the first clinical trial evaluating TAU as new treatment strategy in HIV-infected patients with lipodystrophy and polyneuropathy. |
| WePE0152 | THE IMPACT OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY AND BODY FAT CHANGES ON ENDOTHELIAL FUNCTION IN HIV-INFECTED CHILDREN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0152 A. Dzwonek1, M. Charakida2, J. Halcox2, V. Novelli3, J. Deanfield4, N. Klein1 HAART is associated with endothelial dysfunction, elevated cholesterol and reduced limb fat distribution. However, increased skinfold thickness rather than lipoatrophy is associated with vascular dysfunction in childhood HIV including those on HAART. Our data support a potential role for body composition measurement in vascular risk assessment. |
| WePE0153 | COMPARISON OF APOLIPOPROTEIN B WITH CONVENTIONAL CARDIOVASCULAR RISK FACTORS IN ADULTS WITH HIV+ INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0153 M. Stambullian1, M.S. Feliu2, I. Cassetti3, N. Slobodianik2 In this population, ApoB identifies more patients with cardiovascular risk than the conventional evaluation. The biochemical assessment of ApoB in the routine lipid profile could be helpful detecting patients at risk and giving them an opportune treatment. |
| WePE0154 | LIMITATION OF EXERCISE CAPACITY IN NUCLEOSIDE-TREATED-HIV-INFECTED PATIENTS WITH HYPERLACTATEMIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0154 M. Duong, J.P. Dumas, B. Martha, M. Buisson, L. Piroth, P. Chavanet, H. Portier The degree of exercise limitation in patients with nucleoside-related mitochondrial toxicity correlates directly with the severity of impaired muscle oxidative phosphorylation as indicated by the capacity for muscle oxygen extraction. Exaggerated circulatory and ventilatory responses to exercise are direct consequences of the level of impaired muscle oxidative phosphorylation. |
| WePE0155 | NUCLEOSIDE-ASSOCIATED LACTIC ACIDOSIS IN HIV-1-INFECTED AFRICAN PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0155 P.S. Mwebaze1, B. Castelnuovo1, H. Byakwaga1, L. John1, A. Basenero1, P. Ocama2, R. Colebunders3, E. Katabira4, D. Thomas5, M. Kamya4, A. Kambugu4 These cases highlight NALA as a complication of ART in Africa, where D4T remains an important first line agent, and underscore the importance of a high index of clinical suspicion especially in settings where laboratory monitoring is limited. |
| WePE0156 | CHANGES IN LIPID PROFILE UPON SWITCHING FROM LOPINAVIR/RTV (LPV/R) TO ATAZANAVIR/RTV (ATZ/R) BASED HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0156 S. Guillemi1, A. Toulson2, R. Joy2, J. Toy2, M. Harris2, G. Bondy2, L. Norman2, B. Yip2, R. Hogg2, J. Montaner2 Switching from LPV/r to ATZ/r was associated with statistically significant decreases in TC, TGs and TC/HDL levels sustained for up to 6 months; however, these changes had a modest impact on the Framingham risk scores. |
| WePE0157 | RISK OF HYPERCHOLESTEROLEMIA OVER TIME AMONG PERINATALLY-INFECTED CHILDREN IN PEDIATRIC AIDS CLINICAL TRIALS GROUP (PACTG) 219C Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0157 J. Farley1, K. Tassiopoulos2, P. Williams3, M. Crain4, J. Oleske5, G. Seage2, for the Pediatric AIDS Clinical Trials Group Study 219C Team HC was noted in 12.9% of children at baseline and occurred among 10.9% during follow-up. Boosted and nonboosted PIs were significant risk factors for HC. Higher viral load was protective and may reflect non-adherence with medication. Further follow-up of this cohort will be critical to evaluate the long-term consequences of chronic PI exposure and hypercholesterolemia. |
| WePE0158 | A HISTORY OF STAVUDINE (D4T) PREDICTS HIGH HOMA INDEX THREE YEARS AFTER ART START Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0158 K. Koppel1, B. Lund1, E. Sandström1, J. Sutinen2, G. Bratt1, S. Nielsen3 stavudine has been linked to the loss of subcutaneous fat and in this material we found a significant correlation to the development of increased HOMA index, indicating the development of insulin resistance in non-diabetic patients on ART. Strong efforts should be made to exclude stavudine in all patients where possible. The huge use of stavudine in developing countries may cause serious side effects and thereby threaten adherence. |
| WePE0159 | LIPOPROTEIN (A) IS INCREASED BY ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0159 S. Mauss1, F. Berger1, C. Athmann1, G. Schmutz1, W. Richter2 Substantial increase in lp(a) concentration was mainly restricted to patients with already high lp(a) at baseline. This may have clinical implications as patients with high lp(a) are at higher risk for myocardial infarction and stroke. In addition the lp(a) increase under antiretroviral therapy is remarkable, because no change has been observed so far in the general population due to diet or medical intervention. Lp(a) should be included in studies assessing the influence of HIV and antiretrovirals on cardiovascular risk as it may represent not only a risk factor per se but may be modified by antiretrovirals. |
| WePE0160 | PHOSPHORYLATION OF NATIVE NUCLEOSIDES AND NRTIS BY THYMIDINE KINASE (TK) ISOFORMS RELATES MECHANISTICALLY TO MITOCHONDRIAL TOXICITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0160 J. Kohler1, S. Hosseini1, C. Haase1, T. Ludaway1, J. McNaught1, R. Russ1, N. Tioleco1, E. Keebaugh1, S. Eriksson2, W. Lewis1 Data indicate that disrupted pools of native nucleotides can result from specific activity of TK2 but not TK1 and that phosphorylation of native nucleosides and NRTIs by a specific TK isoform relates mechanistically to mitochondrial toxicity. |
| WePE0161 | MITOCHONDRIAL TOXICITY IS NOT ENHANCED IN IN VITRO MODELS NOR CORRELATED IN IN VIVO MODELS WHERE PRAVASTATIN IS USED IN CONJUNCTION WITH NUCLEOSIDE ANALOGUE CONTAINING ANTIRETROVIRAL THERAPIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0161 P. Sklar1, C. Morse2, M. van Schilfgaarde3, K. Smolders3, M. Buitelaar3, C. Rehm4, S. Owings5, J. Voell4, J. Kovacs2, H. Masur2, M.P. de Baar3 Mitochondrial toxicity induced by certain NRTIs is not enhanced by exposure to pravastatin. The clinical use of this drug in a group analysis of patients on antiretroviral therapy is also not correlated with changes in mtDNA or mtRNA content after 6 weeks of co-administration. Each of the statins seem to have individualized metabolism, potency, and toxicity and need to be further explored at the individual level given their increased use in this patient population. |
| WePE0162 | SMALL, DENSE LOW-DENSITY LIPOPROTEINS (LDL) IN HIV-INFECTED SUBJECTS ON PROTEASE INHIBITOR BASED COMBINATION ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0162 S. Mauss1, F. Berger1, W. Richter2 Prevalence of elevated small dense LDL strongly increases if triglyceride concentration is above 300 mg/dL. It does not further increase at higher concentrations. In about 50% of patients triglyceride concentrations above 300 mg/dl are not associated with elevated small, dense LDL-apoB-100 suggesting different pathomechanisms and cardiovascular risks for the development of hypertriglyceridemia in HIV-infected subjects on protease inhibitors. |
| WePE0163 | CHANGES IN LIPID PROFILES IN TREATMENT-EXPERIENCED PATIENTS SWITCHED TO ATAZANAVIR-BASED ANTIRETROVIRAL THERAPY: RESULTS FROM THE ATAZANAVIR EXPANDED ACCESS PROGRAM (EAP) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0163 P. Keiser1, S. McGrath2, L. Reynolds3, A. Thiry4, T. Guo4, G. Thal5, C. Tong6, L. Bessen7 This large cohort study provides further data supporting the favorable lipid profile of ATV-based regimens. The addition of RTV to ATV-based ART does not appear to negate this favorable profile. However the clinical significance of these findings is unknown, and prospective comparative controlled studies are required to confirm these findings. |
| WePE0164 | LACTATE ASSESSMENT IN HIV POSITIVE PREGNANT WOMEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0164 S. Ivalo, A. Durán, A. Parlante, M. Losso, F. Masciottra, J. Toibaro We observed a mild hyperlactatemia in 38% of pregnancies in this cohort. In most cases co-morbidity was identified and near all cases of repeatedly above normal value was in patients with a large exposure to NRTIs. A diagnostic role of prospective assessment of lactate, in patients with specific features, should be evaluated. |
| WePE0165 | ALCOHOL USE IS DIFFERENTIALLY ASSOCIATED WITH MARKERS OF MITOCHONDRIAL INJURY AMONG HIV+ AND HIV- VETERANS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0165 M. Gerschenson1, D.E. Libutti1, K. Gordon2, K.E.M. Cochrane1, K.L. Garcia1, K. Bryant3, S. Fultz2, A.C. Justice2, Veterans Aging Cohort Study (VACS) Both biomarkers of mitochondrial injury were associated with indicators of alcohol consumption (>7 drinks/week and diagnosis of abuse or dependence) among HIV+ veterans. |
| WePE0166 | METABOLIC SYNDROME AND RELATED DISORDERS IN A COHORT OF HIV-INFECTED PATIENTS FROM MEXICO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0166 Y.A. Vargas-Infante1, C.A. Aguilar-Salinas2, I. Cruz-Bautista2, L. Robles-Contreras2, C. Del Río3, R. Rothenberg3, F.J. Gómez- Pérez2, J.J. Calva-Mercado1, J.G. Sierra-Madero1 In this cohort of HIV-infected patients in Mexico, MS occurs at comparable rates to the non infected population in the country (National Health Survey). Additional factors associated with incident MS should be explored. |
| WePE0167 | DEXA OUTCOMES IN ANTIRETROVIRAL-NAÏVE SUBJECTS RANDOMIZED TO NELFINAVIR OR EFAVIRENZ OR BOTH PLUS DUAL NUCLEOSIDES: LONG-TERM RESULTS FROM A5005S, A SUBSTUDY OF ACTG 384 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0167 M. Dubé1, L. Komarow2, K. Mulligan3, S. Grinspoon4, R. Parker2, G. Robbins5, P. Tebas6, AIDS Clinical Trials Group A5005s and 384 Study Teams Over 144 weeks, ZDV+3TC continued to be superior to ddI+d4T with regards to limb fat loss. In particular, the combination of ZDV+3TC +efavirenz showed no overall pattern suggesting limb fat loss over time and was significantly superior to the pooled ZDV+3TC +nelfinavir (with and without efavirenz) arms. |
| WePE0168 | CONCENTRATION OF CIRCULATING OXIDIZED LDL IN HIV-INFECTED PATIENTS TREATED WITH ANTIRETROVIRAL AGENTS: RELATION TO HIV-RELATED LIPODYSTROPHY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0168 M. Duong, B. Martha, J.M. Petit, M. Grappin, L. Piroth, H. Portier, P. Chavanet The high concentration of oxLDL was found in HIV-infected patients under ART, especially those with lipodystrophy. |
| WePE0169 | A SIGNIFICANT INCREASE IN INCIDENCE OF LACTIC ACIDOSIS AND SYMPTOMATIC HYPERLACTAEMIA IN WOMEN ON HAART IN SOWETO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0169 M. Bolhaar1, A. Karstaedt2 d4T was implicated causally in all but one patient. There was a significantly increased risk of lactic acidosis and symptomatic hyperlactaemia in women on HAART. |
| WePE0170 | HYPERHOMOCYSTEINEMIA IN HIV-1 POSITIVE PATIENTS: THE ROLE OF ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0170 P. Maggi1, G. Parruti2, A. Panebianco1, C. D'Eramo2, V. Carito1, C. Bellacosa1, G. D'Amico2, L. Manzoli3, G. Di Iorio4, G. Pastore1 Our data suggest that both HIV-1 untreated and PI-treated patients have significantly higher homocysteinemia compared with controls. Instead, treatment with NNRTI based regimens seems to reduce homocysteinemia to those of healthy subjects. Regimens based on NNRTIs could exert a protective role against hyperhomocysteinemia in HIV-1 patients. |
| WePE0171 | PHARMACOGENETIC (PG) INVESTIGATION OF HYPERSENSITIVITY TO ABACAVIR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0171 M. Mosteller1, A. Hughes1, L. Warren1, E. Lai1, S. Haneline1, W. Spreen2, C. Brothers2, J. Hernandez2, A. Roses1 A strong association between presumed ABC HSR and HLA-B*5701 carriage was confirmed in this analysis. As retrospective ascertainment of ABC HSR is difficult, the performance characteristics of HLA-B*5701 in reducing ABC HSR are being investigated in a prospective, double-blind, multicenter clinical study that compares the ABC HSR rate between a current standard-of-care ABC treatment group and a prospective PG screening group excluding subjects who carry the HLA-B*5701 allele. Because the rate of ABC HSR and the allele frequency of HLA-B*5701 differ among racial groups, alternative study designs may be needed to investigate ABC HSR in non-Caucasian populations. |
| WePE0172 | INCIDENCE AND PREDICTORS OF HEPATOTOXICITY AMONG PATIENTS RECEIVING NEVIRAPINE (NVP)-CONTAINING ANTIRETROVIRAL THERAPY (ART) IN ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0172 R. Cantrell1, B. Chi1, L. Mulenga1, M. Sinkala2, J. Levy1, E. Stringer1, S. Reid1, M. Bulterys3, I. Zulu4, J. Stringer1 In this large programmatic ART cohort, severe hepatotoxicity was a rare event for individuals on NVP-containing ART. We did not observe a higher risk of transaminase elevation in individuals with higher entry CD4 count. |
| WePE0173 | NEVIRAPINE-ASSOCIATED HEPATIC TOXICITY AMONG HIV-1-SEROPOSITIVE PREGNANT WOMEN IN MOZAMBIQUE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0173 L. Jamisse1, J. Balkus2, J. Hitti3, S. Gloyd4, M. Djedje1, N. Osman5, C. Farquhar6 Hepatic toxicity, peripheral neuropathy, anemia, and skin toxicity were common in this cohort of Mozambican pregnant women on ART. Careful monitoring is recommended for all pregnant women taking ART, especially for those with CD4 counts ≥250 cells/ml. |
| WePE0174 | LOW HEPATOTOXICITY RATES IN A SOUTH AFRICAN COHORT ON NNRTI-BASED ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0174 C. Hoffmann1, S. Charalambous2, L. Pemba2, K. Fielding3, D. Martin4, A. Moss4, G. Churchyard2, C. Thio5, R. Chaisson5, A. Grant3 Despite multiple risk factors for hepatotoxicity during ART, the incidence is lower in this South African cohort than reported from developed countries, supporting the safety of NNRTI-ART in Africa. Further work is needed to confirm safety among other African populations. |
| WePE0175 | ANTIRETROVIRALS INCREASE NEURONAL PRODUCTION AND DISRUPT MICROGLIAL PHAGOCYTOSIS OF β-AMYLOID Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0175 R.D. Shytle, D. Obregon, J. Ehrhart, F. Fernandez, J. Tan Because some of these drugs do penetrate the blood brain barrier, these findings raise the possibility that antiretroviral drugs may play a casual role in the elevated Aβ found in the brains of those infected with HIV and contribute to cognitive decline observed in HAD. |
| WePE0176 | HEPATOTOXICITY IN INJECTION DRUG USERS (IDUS) AND NON-IDUS RECEIVING NEVIRAPINE-BASED HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0176 H. Tossonian1, J. Raffa2, J. Grebely1, C. Hofmann1, A. Mistry1, A. Winther1, M. Viljoen3, S. DeVlaming3, B. Conway1 Clinically significant hepatotoxicity occurred in 15% IDUs and 15% non-IDUs. HCV-infection, being naïve to HAART and abnormal baseline ALT were associated with higher risk of hepatotoxicity. Application of these criteria will allow us to define a population of IDUs and non-IDUs in whom nevirapine-based therapy can be safely prescribed. |
| WePE0177 | OLDER AGE ASSOCIATED WITH REDUCED TOLERABILITY OF ANTIRETROVIRALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0177 M. Silverberg1, W. Leyden1, M. Horberg1, G. Delorenze1, D. Klein2, C. Quesenberry1 Patients ≥50 years of age initiating ARV may require closer monitoring and treatment modification to reduce certain toxicities, particularly metabolic (glucose and lipids), hematologic (neutrophils, hemoglobin) and renal (creatinine) which are more frequent in this age group. |
| WePE0178 | URINARY NO3 EXCRETION AND RENAL FAILURE IN INDINAVIR-TREATED PATIENTS: POTENTIAL ROLE OF NITRIC OXIDE AND RISK FACTORS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0178 M. Eira1, M. Araujo2, A.C. Carvalho de Mello e Silva3, A.C. Seguro4 The lower NO3 excretion suggests that IDV decreases nitric oxide production and the alterations in osmolality and FEH2O can indicate possibility of tubular damage. Renal function of IDV-treated patients should be closely monitored. |
| WePE0179 | MYOCARDIAL INFARCTION RATES AMONG HIV-INFECTED PATIENTS IN A U.S. HEALTH CARE SYSTEM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0179 V. Triant1, H. Lee2, C. Hadigan2, S. Grinspoon2 AMI rates are increased among HIV-infected patients, and HIV is a significant independent risk factor for AMI. Differences in AMI rates are more pronounced among women. As antiretroviral treatment programs continue to expand and more patients are living with HIV globally, monitoring and treating long-term complications such as cardiovascular disease will be important components of HIV care. |
| WePE0180 | ESTIMATING THE UPPER BOUND FOR MORTALITY ASSOCIATED WITH ANTIRETROVIRAL TOXICITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0180 R.S. Braithwaite1, M.S. Roberts2, S. Shechter3, J.L. Goulet1, C.C. Chang4, S.L. Fultz1, M.B. Goetz5, C.L. Gibert6, M. Rodriguez-Barradas7, A. Schaefer3, A.A. Butt4, A.C. Justice1 The upper bound for the excess mortality attributable to ART is large during the first 6 months of therapy, but becomes sharply lower thereafter. |
| WePE0181 | EVALUATION OF HYPOPHOSPHATEMIA IN TENOFOVIR DISOPROXIL FUMARATE (TDF)-EXPOSED AND TDF-UNEXPOSED HIV OUTPATIENTS RECEIVING HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0181 K. Buchacz1, J.T. Brooks1, T. Tong1, A.C. Moorman1, R.K. Baker2, S.D. Holmberg3, A. Greenberg1 The incidence of hypophosphatemia was somewhat elevated but not statistically different among HOPS patients who took TDF-containing versus TDF-sparing HAART during the first one to two years of observation. Longer follow-up of a larger population is needed to determine if this trend toward an association achieves statistical significance and to evaluate the clinical consequences of transient hypophosphatemia. |
| WePE0182 | A MULTIFACETED APPROACH TO RECRUITMENT OF A DIVERSE AND HIGH RISK MSM COHORT FOR PREVENTATIVE VACCINE TRIALS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0182 J. Maynard, D. LeBlanc, R. Vanderwarker, K. Mayer, MD The Fenway Institute at Fenway Community Health will continue its multifaceted approach to high- and low-risk MSM recruitment in HIV preventative studies. Additional recommendations would be to: - Adjust allocation of paid advertisements by tracking the number of contacts leading to eventual study enrollment. - Make greater use of ASOs/BSOs that work primarily with communities of color to broaden diversity of recruited MSM cohort. - Broaden online recruitment utilizing MSM-geared internet sites. |
| WePE0183 | AN INTEGRATED HIV VACCINE RECRUITMENT CAMPAIGN IN ACTION: TARGETED APPROACHES FOR ENROLLMENT OF DIVERSE POPULATIONS IN A PHASE II STUDY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0183 P. Frew1, L. Lu2 The integrated strategy has yielded notable response and enrollment rates from women and minorities. "Traditional" outreach methods that include the dissemination of materials in clubs, bars, and at community venues, may be less effective than internet-based outreach (email messaging, listserv postings, website advertising and listings), followed by mass media to reach the target population. Methods that target those with higher educational attainment levels may result in stronger enrollment rates. |
| WePE0184 | LESSONS LEARNED IN DEVELOPING RESEARCH COUNSELING AND TESTING (RCT) IN EAST AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0184 N. Bahati1, J. Nyange2, O. Anzala2, M.R. Rwanyonga2, A. Kamali2, H. Oguto2, B. Bender1, A. von Lieven3, E. Sanders4, S. Hannah1, M. Price5, S. Kalibala1 Quality HIV counseling and testing models in research context requires research specific training approaches and QA that meet both volunteers´ psychosocial needs and research needs. Continuous volunteer and staff feedback is important to meeting that goal. |
| WePE0185 | WORKING TOGETHER FOR AN AIDS VACCINE: BUILDING INNOVATIVE PARTNERSHIP AND PUBLIC OWNERSHIP Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0185 S. Das1, A. Nayyar2, M. Chataway3, A. Sinha1, S. Kochhar4, J.L. Excler4 A consultative, transparent and dynamic public ownership mobilizes new energy and expertise by fostering understanding amongst critical stakeholders and ensuring a culturally sensitive and locally relevant process. |
| WePE0186 | MOTIVATION TO PARTICIPATE IN HIV VACCINE TRIALS IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0186 E. Mugisha1, L. Nielsen2, F. Nakwagala1, A. Nanvubya1, C. Konde1, P. Kaleebu1, J. de Bont2, C. Schmidt2 The use of multiple stages of recruitment allows PV an opportunity to re-evaluate their willingness and motivation to participate and may improve understanding, excluding PVs motivated to join trials for personal gains such as financial or health care. |
| WePE0187 | BUILDING AND RETAINING A GROUP OF POTENTIAL VOLUNTEERS FOR HIV VACCINE TRIALS IN RIO DE JANEIRO, BRAZIL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0187 M. Souza, G. Santos, J. Pedrosa, C. Yoshida, M. Schechter In order to enroll the expected number of volunteers into a trial, research sites may consider creating a plan to access and keep track of a large number of individuals long before protocol initiation. It is also very important to put in place strategies that allow researchers to identify volunteers´ motivation to participate in trials, trying to differentiate first impulses from long-term commitments. |
| WePE0188 | MOLECULAR HOMOLOGY BETWEEN CANARYPOX VIRUS 005 AND SPINAL CORD MYELIN BASIC PROTEIN EXPLAIN AIDS VACCINE-INDUCED MYELITIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0188 M.K.G. Tran1, A. Caprani2, S. Kirkiacharian3 There is a significant molecular homology between canarypox virus and spinal cord MBP, shared by encephalomyelitogenic (vaccinia, measles, Theiler´s) viruses, suggesting an auto-immune myelitis after AIDS vaccine, possibly HLA-DR15 restricted. This neurotoxic epitope should be deleted in canarypox or Ankara virus. This does not guarantee a complete innocuity (RFSW, LSLTHFS are common to MBP and canarypox, vaccinia viruses...). Nevertheless clinical trials using canarypox virus vector can be persued and safe if HLADR15 typing is previously performed. |
| WePE0189 | SITE PREPAREDNESS FOR AIDS VACCINE CLINICAL TRIALS IN INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0189 S. Kochhar1, S. Das2, A. Nayyar3, G. Stevens4, J.-L. Excler1 AIDS vaccine development requires strong political leadership, commitment, medical and scientific expertise, community participation and collaboration and careful preparation and team management. |
| WePE0190 | CLINICAL TRIALS OF THE FIRST RUSSIAN HIV VACCINE VICHREPOL ARE IN PROGRESS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0190 I. Nikolaeva1, S. Korobova1, A. Chevalier2, G. Gudima1, J. Gornostaeva1, L. Trubcheninova1, T. Klimenko3, B. Pinegin1, A. Chernousov1, V. Gasanov1, A. Kiselev1, E. Karamov4, G. Kornilaeva4, T. Pavlova4, R. Khaitov1, I. Sidorovich1 These preliminary data demonstrate preventive vaccine safety and tolerability. VICHREPOL can also be considered for the boost immunization as a part of prime-boost protocol, both for preventive and therapeutic vaccination. Work on appropriate p(24-41) DNA vaccine for the prime immunization is now under way. |
| WePE0191 | CLINICAL CARE PACKAGE FOR AIDS VACCINE TRIAL PARTICIPANTS IN INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0191 A. Shrotri1, S. Sahay2, S. Kochhar3, J.L. Excler3, R. Paranjape2, S. Mehendale2 Research team and protocol reviewers need to address concerns expressed by the community through expert consultation and effective dialogue between the investigators, community representatives and sponsors. The community advisory board can play a facilitating role in bringing about such interactions. |
| WePE0192 | VACCINE SUPPORT NETWORKING: PREPARING COMMUNITY FOR AIDS VACCINE TRAIL PARTICIPATION IN THE RIFT VALLEY IN KENYA; LINKING RESEARCH TO COMMUNITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0192 S.M. Tuvako, Dr. Stanley Kiplagat and Charles Kilel (Walter Reed, Kericho, Kenya), Edward Amani (Vaccine Support Network, Nakuru), Janet Feldman (ActALIVE), Sabena Wakasiaka (Kenya AIDS Vaccine Initiative) HIV/AIDS is one of the worst pandemic the world has ever seen. Behavioral prevention strategies have slowed the epidemic in some areas of the world, but have not stopped it. A preventive AIDS Vaccine is thus needed as well as other intervention like Microbicides. Researchers world over are working towards the development of these vaccines as well as microbicides. Clinical trails are already on the way in many nations. However, for successful trials of all phases, community participation is important which by itself, is faced with enormous challenges. Historically myths, suspicions and misconceptions have resulted in failures of such trials mostly because the community has no understanding or information about such trials. Since researchers need community to complete their trials, there is need for community to be prepared beforehand to ease entry for trial participation. |
| WePE0193 | GENDER CONCERNS IN HIV VACCINE RESEARCH: REFLECTIONS FROM KEY STAKEHOLDERS IN EAST AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0193 L. Nyblade1, J. Becker2, S. Kalibala3, F. Manguyu3, B. Bender3, J. Bwayo4, E. Ngugi4, E. Mugisha5 Gender may influence not only an individual´s willingness to enroll and continue participation, but also how families and communities respond in supporting participation. Applying a gender lens to understanding the motivations, fears, enabling factors and constraints of women and men around participation, and using that information to shape support systems, recruitment and retention strategies will strengthen the potential for a successful outcome. |
| WePE0194 | PREVALENCE OF NEUTRALIZING ACTIVITY TO AAV-BASED HIV-VACCINE CANDIDATES IN SELECTED COUNTRIES IN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0194 D. Jacobson1, L. Wilson1, A. Heald1, P. Fast2, M. Katende3, M. Boaz4, S. Loewenbein4, E. Kizito4, S. Than2, O. Manigart5, J. Birungi6, H. Jaspan7, B. Farah8, J. Bizimana9, E. Karita9, O. Anzala8, P. Kaleebu6, L.-G. Bekker7, P. Mugyenyi3, R. Peluso1 The relationship of pre-existing neutralizing antibodies to safety and immunogenicity of the vaccine will be determined in ongoing clinical studies. |
| WePE0195 | REGULATORY AND ETHICAL APPROVAL FOR AIDS VACCINE CLINICAL TRIALS - EXPERIENCE FROM FIVE DEVELOPING COUNTRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0195 J. Milstien1, R. Hecht2, S. Post3 As an increasing number of AIDS vaccine candidates enter clinical trials in developing countries, improved regulatory and ethical trial review is needed. Delays and inefficiencies could potentially slow the successful development of a vaccine. |
| WePE0196 | REASONS VOLUNTEERS FROM PHAN THONG DISTRICT, CHON BURI PROVINCE, THAILAND MISSED APPOINTMENTS WHILE PARTICIPATING IN A PHASE III HIV VACCINE TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0196 R. Pummarin Volunteer retention is critical for the success of a clinical trial. The objective was to identify the reasons volunteers missed scheduled appointments. |
| WePE0197 | WHO´S GLOBAL AND REGIONAL INITIATIVES TO SUPPORT REGULATION OF HIV VACCINE CLINICAL TRIALS IN DEVELOPING COUNTRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0197 L. Chocarro1, L. Belgharbi2, M. Dicko2, N. Dellepiane2, D. Wood2, M. Thiam2, C. Touré2, S. Osmanov2, M.P. Kieny2 Capacity-strengthening efforts can help ensure that developing country NRAs can access training opportunities and improve trial evaluation procedures. This effort is critical to enhance regulatory capacity for the authorization and oversight of HIV vaccine trials. |
| WePE0198 | PERSONAL EXPERIENCE AS A VOLUNTEER IN AN HIV VACCINE TRIAL IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0198 W.T. Richard1, E. Mugisha2 To overcome fears and myths, as a volunteer, one needs to constantly talk to his/her peers. The Youth need to join in the search for an HIV vaccine since they will be the ultimate users when discovered. Personal benefits from volunteering should be de-emphasized and a commitment to end the AIDS epidemic with the discovery of a vaccine shoulf be highlighted. Volunteering cannot make one get sick with strange diseases as some as some think. I participated and my life has become even better. |
| WePE0199 | DEMOGRAPHIC CHARACTERISTICS OF PREVALENT HIV-INFECTED VOLUNTEERS SCREENED FOR THE PHASE III HIV VACCINE TRIAL, SATTAHIP DISTRICT, CHON BURI PROVINCE, THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0199 N. Sawasdeemee Community education programs should encourage people to be tested because the infected volunteers did not realize their status. Women should be targeted for education about risk behavior and encouraged to use condoms. |
| WePE0200 | WILLINGNESS TO PARTICIPATE IN HIV VACCINE TRIALS AMONG ARTISANS IN IBADAN, NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0200 O. Onigbogi1, C. Famoyin2, M. Fatokun3 The level of WTP among the artisans suggests that HIV vaccines may be widely accepted if eventually introduced among them. The general level of awareness about HIV/AIDS and sexually transmitted diseases among this group of people should be increased because this will assist in increasing the level of WTP. Larger studies involving focus group discussions and in-depth interviews will be required to further investigate perceived merits and demerits. |
| WePE0201 | MONITORING PARTICIPANT SAFETY IN HIV VACCINE TRIALS - A THREE-TIERED APPROACH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0201 P. Farrell, W. Brown, M. Cooney, H.-Y. Huang, D. Robinett, C. Stephenson, M. Swenson, S. Wroblewski This tiered safety review system has demonstrated the ability to identify potential safety concerns in a timely manner and to ensure the quality and accuracy of clinical and lab data. |
| WePE0202 | MIGRATION AND HIV VACCINE DEVELOPMENT IN MASIPHUMELELE, WESTERN CAPE, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0202 G.M. Clark1, L. Swartz2 The study population was fairly stable; job opportunities, the primary determinant of residence, were thought to be comparatively plentiful in Masiphumelele. A "Christmas exodus" to the Eastern Cape was identified as the main migration concern for vaccine trials to accommodate. Nearly all participants reported that HIV had affected their lives, and, consistent with the hypothesized overriding importance of HIV impact, nearly all indicated interest in vaccine trials. |
| WePE0203 | ESTABLISHING STANDARDS OF CARE AND TREATMENT IN THE CONTEXT OF VACCINE TRIALS: FROM PRINCIPLES TO PRACTICE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0203 D. Tarantola, for the Study Group on Access to Care in Vaccine Trials: Macklin R, Lie R, Barsdoff N, Stobi M, Greco D, Capron A, Preziosi MP, Ottoson C, Kieny MP, Reed Z, Osmanov S. The practical guidance aims at ensuring that vaccine trials meet international scientific and ethical standards while offering pre-determined, optimal and sustainable care, treatment and support. |
| WePE0204 | THERAPEUTIC VACCINATION WITH RECOMBINANT MVA.HIVA VACCINE (GAG P24 AND P17) SIGNIFICANTLY BOOSTS T CELL RESPONSES IN CHRONICALLY INFECTED HAART TREATED HIV-1 PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0204 B.O. Ondondo1, H. Yang2, A. Suttil2, C. Conlon2, D. Brown2, P. Williams2, T. Rostron2, S. Rowland-Jones2, T. Hanke2, A. McMichael2, L. Dorrell2 MVA.HIVA immunization can boost functional T helper responses that could help control viral replication. Further studies are planned to assess the capacity of vaccine-stimulated T cells to suppress viral replication in the absence of HAART. |
| WePE0205 | PREDICTIVE FACTORS RELATED TO THE IMMUNOVIROLOGICAL OUTCOME IN HIV-1+ PATIENTS UNDERGOING ANALYTICAL TREATMENT INTERRUPTION FOLLOWING THERAPEUTIC VACCINATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0205 C. Rodríguez-Sainz1, L. Valor2, M. Desco3, J. Navarro2, D. Podzamczer4, B. Santamaria2, J. González Lahoz5, J. Carbone2, S. Moreno6, J. Gil2, E. Bouza7, B. Clotet8, P. Viciana9, I. Ocaña10, R. Rubio11, F. Pulido11, J. Maradona12, C. Quereda6, R. Blazquez13, E. Ferrer4, M. Díaz10, A. Jou8, J. Peña14, G. Sirera8, P. Gijín15, J. Gatell16, F. Lípez17, E. Fernandez-Cruz2 The data show that CD4 pre-ART levels , the number of immunizations and CD4+ HIV-specific responses during ATI are strong predictive factors for a better control of viremia during ATI. |
| WePE0206 | INTERLEUKIN-2 (IL-2) THERAPY LOWERS THE RISK OF OPPORTUNISTIC INFECTIONS IN HIV-INFECTED PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0206 E. Fontas1, I. Kousignian2, C. Pradier3, C. Duvivier4, I. Poizot-Martin5, C. Durier6, B. Jarousse7, L. Weiss8, Y. Levy9, D. Costagliola10, ANRS CO4 and ANRS CO14 As compared to HIV patients not exposed to IL-2, HIV patients exposed to IL-2 therapy are at lower risk of AIDS defining events. In this observational setting, this clinical effectiveness appears to concern mostly patients with low CD4 counts. |
| WePE0207 | IMMUNOLOGICAL CHANGES IN HIV-1-INFECTED PATIENTS HAVING RECEIVED THYMUS NUCLEAR PROTEIN (TNP) INJECTIONS: RESULTS OF A RANDOMISED, PLACEBO-CONTROLLED, DOUBLE BLIND STUDY IN SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0207 P.J.D. Bouic1, A. Clark1, A.-R. Louw1, H. Zhabilov2, H. Kheledjian2, J. Hwang2 This is the first time that data demonstrates that TNP has subtle immunological activity. It appears that the control of HIV replication and subsequent VL drop is due to the activation of viral specific responses and an enhancement of CTL activity. |
| WePE0208 | INTERFERON ALPHA THERAPY PRODUCES SIGNIFICANT DECREASES IN SERUM HIV LOAD Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0208 J.A. Tavel1, C.-Y. Huang1, J. Shen2, D.A. Follman1, A. Shah3, J.A. Metcalf1, R.T. Davey, Jr.1, M.A. Polis1, J. Kovacs2, H. Masur2, H.C. Lane1 Treatment with subcutaneous interferon alpha produces a significant decrease in serum HIV load but no significant change in total CD4+ lymphocyte count, or in time to HIV disease progression. Given its antiretroviral activity, additional studies of interferon alpha as part of a combination regimen are warranted. |
| WePE0209 | CONSTRUCTION OF AN EXPRESSION VECTOR CONTAINING IMMUNOGENIC EPITOPES OF HIV-1 P24 AND GP41 PROTEINS AS DNA VACCINE CANDIDATE AGAINST HIV-1 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0209 F. Roodbari1, F. Barkhordary2, F. Sabahi1, R. Sarami Forooshani2, A. Adeli2, T. Bamdad1, F. Mahboudi2 In this study, an expression vector (PCDNA3.1 hygro) containing P24-gp41 immunogenic sequences under the control of IE HCMV promoter was designed. The expression of the recombinant peptides was analyzed in an eukaryotic systems, such as COS-7 and Hela cells. Immunofluorescence and western blotting confirmed the presence of expressed proteins. Conclusions: The cited above polyvalent P24-gp41 fusion gene that is able to express in a proper folding form. This fusion gene will be studied as DNA vaccine vector will be used in an animal model for evaluation and generation of effective immune responses. |
| WePE0210 | HYDROXYUREA EXERTS A POTENT CYTOSTATIC ACTION ON T LYMPHOCYTES BUT HAS NO DIRECT EFFECT ON T CELL ACTIVATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0210 J.M. Benito, M. López, C. Ballesteros, S. Lozano, V. Soriano, J. Gonzalez-laHoz Any beneficial immunomodulatory effect of HU is mediated through its potent cytostatic effect on T cells, as it has no direct impact on T cell activation. |
| WePE0211 | HIV-INFECTED CHILDREN LIVING IN CENTRAL AFRICA HAVE A LOWER ANTIBODY RESPONSE TO VACCINES USED IN THE EXPANDED PROGRAM ON IMMUNIZATION (EPI) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0211 M.C. Tejiokem1, I. Gouandjika2, L. Beniguel3, M.-C. Endengue Zanga4, G. Tene5, J.C. Gody6, E. Njamkepo7, J. Kfutwah4, C. Ngongueu6, D. Rousset4, I. Penda8, C. Bilong9, V. Maréchal3, R. Pouillot1, L. Baril10 The proportion of children with detectable antibody responses to EPI vaccines was lower in HIV-infected as compared to uninfected children. The response to a single dose of measles vaccine was considerably low in HIV-infected children with low CD4 count, indicating an incapacity to mount an efficient humoral response to measles vaccine. Besides, our study revealed that uninfected children responded lower than expected to EPI vaccines, suggesting the implication of other factors. The need of improving routine childhood immunization in Central Africa will be discussed. |
| WePE0212 | IMMUNOLOGIC EVOLUTION OF HIV-HCV-CO-INFECTED PATIENTS AFTER IFN+RBV TREATMENT BETWEEN PATIENTS ON HAART AND PATIENTS WHO CEASED ANTIRETROVIRAL TREATMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0212 B. de Felipe, S. Gutierrez, A. Sanchez-Quijano, E. Lissen, M. Leal, A. Vallejo IFN-PEG/RBV therapy without antiretroviral treatment did not improve virological response. CD4+ counts remains higher in patients on antiretroviral interruption. HCV genotype 1-infected patients have an earliest virological response in group A. |
| WePE0213 | QUALITY OF LIFE AND LONGEVITY IN A COMMUNITY CLINIC OFFERING NON ART THERAPY IN RESOURCE LIMITED SETTING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0213 L. Vadrevu1, R. Vadrevu2, I. Isukapatla3, R.p.l.n. Manthena4 In resource limited settings while we all wait for unversal ART coverage it is better to start community clinics in least cost setup to offer better QOL to PLWHA. |
| WePE0214 | DEVELOPMENT OF THE UCSF HIV/AIDS SELF-CARE SYMPTOM MANAGEMENT MANUAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0214 W. Holzemer1, C. Portillo1, D. Wantland1, F.-y. Chou2, S. Human3, N. Sukati4, L. Makoae5, N. Seboni6, E. Roman7, M. Rivero7, Y. Cuca1 The UCSF International Nursing Network for HIV/AIDS Research is currently conducting a multi-national, multi-site randomized controlled trial of the efficacy of the manual. |
| WePE0215 | STRENGTHENING LABORATORY SERVICES TO SUPPORT HIV/AIDS DIAGNOSIS AND TREATMENT IN UGANDA: AMREF EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0215 C. Munafu1, J. Carter2, R. Mukisa3, P. Martha3, J. Kyallo3 Diagnostic strengthening programmes must address capacity building of both clinical and laboratory staff. Programmes targeting control of specified diseases may be used to strengthen all basic functions of the laboratory services for societal benefit. |
| WePE0216 | IMPLEMENTATION OF A PROGRAM TO IMPROVE CLINIC - BASED HIV SCREENING AND TESTING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0216 M. Goetz1, B. Rossman1, T. Hoang1, H. Anaya1, J. Burgess2, B. Volpp3, T. Osborn4, C. Bowman5, A. Gifford5, S. Asch1, VA QUERI-HIV These results show that the coordinated use of audit/feedback reports with a computerized clinical reminder, provider education and removal of systemic barriers can significantly increase HIV testing for at-risk VHA patients. |
| WePE0217 | COST IMPLICATIONS OF THE PROVISION OF CARE IN A CLINICAL TRIAL AMONG HIV-INFECTED MOTHERS AND THEIR INFANTS IN MALAWI: THE BAN STUDY EXPERIENCE IN LILONGWE, MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0217 C. Chasela1, Z. Ramdas1, B. Bramson1, L. Hyde1, C. Chavula1, N. Mumba1, M. Majawa1, A. Soko1, M. Chigwenembe1, H. Eliya1, D. Chilongozi1, G. Tegha1, G. Joaki1, A. Manja1, F. Martinson1, I. Hoffman2, C. Merry3, M. Ryan3, P. Kazembe4, C. van der Horst2 Costs for the provision of standard of care are often underestimated, and should be specifically factored in clinical trial budgets. In under-resourced settings, access to and the quality of the existing health care facilities, local disease patterns, the high demand, and the need for capacity building should all be taken into account. |
| WePE0218 | CONTINUED DECLINES IN MORTALITY AND HOSPITALIZATION DURING THE 10-YEAR ERA OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY IN HIV+ PATIENTS RECEIVING CARE AT AN UNIVERSITY-BASED CLINICAL PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0218 J. Koeppe1, O. Lorri2, J. Steven1 Mortality among HIV+ persons in care in our clinic has declined by more than half between the first and second half of the HAART era. Although most of this has been due to decreases in AIDS related mortality there has also been a significant decline in non-AIDS related mortality during this time. |
| WePE0219 | DISCORDANCE BETWEEN MASS BODY INDEX (IMC) AND ANTHROPOMETRY EVALUATION AMONG HIV-INFECTED PATIENTS WITH LIPODYSTROPHY UNDERGOING HAART Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0219 L. Soares1, D. Cardeal2, A. Almeida2, M. Mendonca2, C. Gonsalez2, A.J.S. Duarte2, J. Casseb3 The prevalence of lipodystrophy ranges from 5% to 40% among HIV-infected patients undergoing HAART. This diagnosis may mask some nutritional problems. |
| WePE0220 | DEVELOPING AND IMPLEMENTING A PREVENTIVE CARE CHECKLIST FOR HIV POSITIVE IMMIGRANT WOMEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0220 K. Pottie1, C. Kendall1, C. Touchie2, P. Topp3 Developing a nonjudgmental transparent start-up approach preventive care is one way of improving the delivery of primary care to HIV positive immigrant women. The development of a preventive care checklist offers a local initiative to improve the delivery of preventive care services that has the potential to improve the chances for long-term continuity of primary care. |
| WePE0221 | PREVALENCE OF AND VARIABLES ASSOCIATED WITH POOR GLYCEMIC CONTROL IN HIV+ PATIENTS (PTS) ON DIABETES TREATMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0221 M. Liss, M. Glesby, C. Vaamonde Poor glycemic control was common in this urban HIV care center with 49% of subjects having a GHb above the ADA goal of 7%, and 29% of subjects with a GHb > 8%. Studies looking at integrating diabetes management into HIV primary care may be warranted. |
| WePE0222 | HIV EDUCATION FOR PRACTITIONERS IN PRIMARY CARE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0222 P. Clift1, A. Cressey2 That this course is accepted and implemented as the standard in settings where HIV is a chronic manageable illness, with financial inducements if necessary. |
| WePE0223 | FACTORS ASSOCIATED WITH PAIN IN HIV-POSITIVE PATIENTS IN A MULTISITE, MULTISTATE HIV COHORT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0223 J.S. Josephs1, J.A. Fleishman2, P.B. Lawrence1, W.C. Mathews3, R.D. Moore1, K.A. Gebo1, for the HIV Research Network Pain in HIV patients is very common, especially in whites, those with greater education, and those who formerly used illicit drugs. Level of pain may be lower in current drug users due to the use of narcotics to reduce pain. Future studies evaluating the effectiveness of pain medications on the level of pain are needed to adequately address this important quality of life issue. |
| WePE0224 | THE CINDERELLA OF CARE - COMMUNITY ADHERENCE PROGRAMME (CAP) AND THE SOUTH AFRICAN ARV ROLLOUT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0224 A. Grimwood1, A. Jason2, H. Hausler3, N. Schaay4 Any wide scale community ARV treatment strategy needs be supported by a well resourced CAP that utilizes any local community worker able to provide adherence support for patients. |
| WePE0225 | RISK FACTORS FOR PRESENTING WITH ADVANCED HIV INFECTION: RESULTS FROM MASSACHUSETTS STATEWIDE CHART REVIEWS 2002-03 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0225 L. Kunches, L. Hirschhorn, N. Reinhalter, E. Coakley, J. Musolino, J. Ban, Massachusetts Department of Public Health and Boston Factors associated with delayed care-seeking point out the continuing need for social marketing and targeted outreach to promote HIV testing/diagnosis and facilitate entry to care for men, Hispanics and immigrants. Locations outside large metropolitan areas may pose particular challenges so efforts to decrease barriers (including stigma), publicize and deliver culturally and linguistically appropriate health services are critical. |
| WePE0226 | A CASE CONTROL STUDY OF THE PREVALENCE OF HYPERTENSION IN AN HIV-INFECTED POPULATION COMPARED TO A HEALTHY AGE, SEX AND RACE MATCHED CONTROL GROUP Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0226 T. Crook1, D. Ahuja2, C. Modesir3, J. Zurlo1 Our study has demonstrated a higher prevalence of hypertension among our HIV-infected population compared to age, sex and race matched controls. Further investigation of potential risk factors for hypertension associated with HIV infection is now planned. |
| WePE0227 | VALIDATION OF FOUR HIV-SPECIFIC PSYCHOLOGICAL SCALES AMONG HIV-INFECTED FARMERS IN RURAL CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0227 L. Xiao, T. Xu, S. Sullivan, J. Xu, Z. Wu Overall, the culturally-modified HIV Stigma and HIV-SE scales can be used in rural settings of China. Some subdomains performed quite well and are worth considering for use. However, there were several problems with each of the scales which were possibly associated with insufficient training. |
| WePE0228 | USING WEB-BASED PATIENT VIGNETTES TO MEASURE HIV CLINICAL TRAINING EFFECTIVENESS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0228 J. Myers1, O. Bacon2, R. Vezina1, J. Rodnick3 Administering clinical vignettes longitudinally is a valuable and innovative approach to measuring training effectiveness. |
| WePE0229 | READINESS FOR CHANGE TOOL: PREVENTION OF SEXUALLY TRANSMITTED INFECTIONS (STI) AND HIV - A RESOURCE FOR GENERAL PRACTITIONERS (GPS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0229 R. Hennessy1, L. Mccann2, B. Edwards3, D. Austin4, A. Ogier5, D. Conway6, A. D'amato7, L. Ryan8 GPs and other health practitioners have welcomed a resource that provides practical examples and transferable skills that they can put into practice. The next steps are qualitative and quantitative evaluations after 3 months of implementation. Such tools could form a template for future resource development in many health promotion areas. |
| WePE0230 | CLINICAL EFFECTIVENESS OF INFLUENZA VACCINES IN HIV-INFECTED INDIVIDUALS: A META-ANALYSIS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0230 J. Atashili, L. Kalilani, A. Adimora Current evidence suggests that influenza vaccines are effective in reducing the incidence of influenza in HIV-infected individuals. Vaccination is thus a potentially useful intervention and should be recommended to HIV-infected individuals in whom there are no safety concerns. |
| WePE0231 | THE EFFECT OF MULTI-VITAMIN/MINERAL SUPPLEMENTATION ON MORTALITY DURING TREATMENT OF PULMONARY TB: A RANDOMISED TWO-BY-TWO FACTORIAL TRIAL IN MWANZA, TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0231 N. Range1, J. Changalucha2, H. Krarup3, P. Magnussen4, A. Andersen5, H. Friis6 Supplementation with multi-vitamins/minerals, including zinc during treatment of pulmonary TB may reduce mortality in those co-infected with HIV. A randomised trial of effect of the combined intervention used in this study should be conducted in a different setting to confirm the finding. |
| WePE0232 | EVALUATING HIV/AIDS CLINICAL TRAINERS' PROFESSIONAL DEVELOPMENT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0232 K. To1, R. Vezina1, M. Bernstein2, J. Myers1, E.M. Reyes2, S. Morin1 AETCs should continue to provide professional development to its faculty in order for them to effectively provide high quality training in HIV/AIDS clinical treatment and care. Continued evaluation of the conference will identify trends over time in the needs and training outcomes for its faculty. |
| WePE0233 | AVALABILITY OF FACILITIES,CARE AND SUPPORT FOR PLWHA IN PRISON COMMUNITY IN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0233 I.G. Iwoh, R.C. Akpan, D.E. Ofobrukweta The issue of care and support for the infected (inmates and staff) needs to be addressed in the prisons. Supply of palliative care, good food, skin piercing instruments (like razor blade and syringes) should be supplied adequate and government effort should be complimented. There is need to also establish a support group within the prison. |
| WePE0234 | "PREVENTION FOR POSITIVES" IN CLINICAL PRACTICE: QUALITY MANAGEMENT AND IMPROVEMENT IN PROVIDER PRACTICES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0234 L. Hirschhorn1, L. Kunches2, N. Reinhalter2, J. Musolino2, Massachusetts Department of Public Health and Boston Public Health Commission Clinical Quality Management Group Efforts aimed at increasing PfP in the clinical setting were associated with increase in RR counseling and syphilis screening. Rates of SA treatment remained high and rates of STIs remained low. |
| WePE0235 | REDESIGNING A MODEL OF CARE: CASEY HOUSE'S RESPONSE TO THE CHANGING NATURE OF HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0235 J. Lesmond1, L. Muir2 In collaboration with its communities, Casey House will implement, evaluate and report on the effectivenes. |
| WePE0236 | CORRELATION OF HBA1C AND MEAN PLASMA GLUCOSE IN HIV-INFECTED PATIENTS WITH DIABETES MELLITUS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0236 C. Jackson1, K. Abernathy2, R. Clinicea3 Due to small sample size, no statistically significant differences were confirmed. However, a trend was found for the underestimation of mean glucose by measured HbA1c in this patient population. Larger studies are needed to explain this phenomenon with respect to specific antiretrovirals. |
| WePE0237 | QUALITY HEALTH SERVICES FOR INJECTING DRUG USERS (IDUS) AT A RURAL HEALTH CENTER IN INDONESIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0237 E.B. Wachjuni We now to extend these basic services to become a one-stop clinic offering needle exchange, methadone maintenence, and HIV treatment, including management of antiretroviral therapy to those who need it, working with the nearest referral hospital. More efforts are also needed to encourage acceptance of IDUs with AIDS by families and the community, including guidance on home care preparing bodies for burial. |
| WePE0238 | INTEGRATED PAIN MANAGEMENT FOR PATIENTS WITH HIV RECEIVING CARE IN A PUBLIC SETTING: PRELIMINARY RESULTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0238 J. Trafton1, J. Sorrell2, P. Link1, M. Holodniy1, D. Israelski3 This therapy is feasible and well-accepted when integrated into primary care settings. Preliminary analysis suggests that enrollment in this therapy is associated with reductions in pain and impairment in patients with HIV/AIDS. |
| WePE0239 | HOW GOOD IS THE CARE? RESULTS OF A LONGITUDINAL QUALITY OF CARE PROGRAM IN PUBLICLY-FUNDED CLINICS IN MASSACHUSETTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0239 L. Hirschhorn, L. Kunches, N. Reinhalter, J. Musolino, Massachusetts Department of Public Health and Boston Public Health Despite serving populations with multiple comorbidities, high rates of recommended care were seen in many areas, with improvement in others that had been a focus of QI. Some annual screening rates were lower in continuing patients than in newly diagnosed, illustrating the challenge of maintaining screening behavior in ongoing care. |
| WePE0240 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0240 Abstract not available |
| WePE0241 | A RANDOMIZED CONTROLLED TRIAL OF PROPHYLACTIC ANTIBIOTICS FOR THE PREVENTION OF POSTPARTUM INFECTIOUS MORBIDITY IN HIV-INFECTED WOMEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0241 H. Sebitloane1, J. Moodley2, Women's Health and HIV Research Unit Administration of intrapartum prophylactic antibiotics is associated with reduction of postpartum infectious complications among HIV-infected women, particularly when immuno-compromised. |
| WePE0242 | PROMOTING CERVICAL CANCER SCREENING FOR WOMEN WITH HIV/AIDS IN THE PILOT IMPLEMENTATION IN 3 PROVINCES IN THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0242 K. Fakthongkham1, P. Ningsanond1, T. Leusaree2, K. Jiatha2 This project has improved a part of quality of care for PHA. The model and interventions will be used to expand to other hospitals at the national scale. |
| WePE0243 | GENDER DIFFERENCES IN A LARGE-SCALE HAART PROGRAM IN WESTERN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0243 E. Carillo de Casas, H. Cox, C. Ferreyra, P. Isaakidis, C. Mansilla, M.J. San Miguel, S. Moore, F. Mitjavilla, A. Revuelta, M. Rodriguez These results suggest that, in our setting, women respond better to antiretroviral treatment and that this is reflected in better survival. Whether this is due to biological or social and behavioural factors warrants further investigation. |
| WePE0244 | TUBAL STERILIZATION (BTL) DURING CESAREAN SECTION (CS) FOR PREVENTION OF MOTHER-TO-CHILD-TRANSMISSION (MTCT) IN HIV-INFECTED (HIV+) PREGNANT WOMEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0244 S. Barbee1, E. Livingston2, L. Brancazio2 The objective was to examine if desire for BTL might play a role in decisions HIV+ pregnant women make regarding their mode of delivery- CS versus vaginal delivery (VD). |
| WePE0245 | UPTAKE OF THE HEALTH CARE SERVICES AND THE HEALTH STATUS OF THE HIV-INFECTED WOMEN DIAGNOSED FROM THE ANTENATAL HIV SCREENING, IN BARBADOS, 1996-2004 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0245 A. Kumar1, K. Kilaru2, S. Forde3, I. Waterman3 These HIV-infected women had significant mortality and it was largely related to the lack of follow up or presenting for follow quite late in their illness despite the provision for free care and treatment. |
| WePE0246 | CLINICALLY-SIGNIFICANT ANEMIA IN HIV-INFECTED PREGNANT WOMEN IN INDIA IS NOT A MAJOR BARRIER TO USE OF ZIDOVUDINE FOR PREVENTION OF MATERNAL TO CHILD TRANSMISSION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0246 G. Sinha1, J. Choi1, U. Nayak1, A. Gupta1, S. Nair2, P.M. Bulakh3, J. Sastry4, S.D. Deshmukh5, M.M. Khandekar2, A.V. Bhore2, R. R. Melinkeri2, V.P. Kulkarni4, R.A. Bhosale2, P.R. Naphade2, K.E. Bharucha6, M.A. Phadke7, A.S. Kshirsagar8, R.C. Bollinger1, on behalf of the MIT Study, Pune, India A significant proportion of HIV+ pregnant women in India present for antenatal care with anemia. Accordingly, a relatively small proportion is treated with zidovudine for PMTCT. However, likely due to special attention to treat antenatal anemia in this study population, zidovudine does not impede recovery from anemia at delivery. In the community, all pregnant HIV+ Indian women should have baseline anemia screening and treatment. Anemia should not limit initiation or continuation of zidovudine for PMTCT. |
| WePE0247 | CD4 COUNT AND MONTHLY INCOME PREDICT CERVICAL SQUAMOUS CELL ABNORMALITIES IN PAP SMEAR: RESULTS FROM THE WOMEN'S HEALTH CLINIC AT THE ANONYMOUS CLINIC OF THE THAI RED CROSS AIDS RESEARCH CENTRE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0247 S. Mangclaviraj1, S. Chaitonwonwatana2, S. Kerr3, B. Hirschel4, J. Ananworanich5, S. Emory6, D. Cooper7, L. Kametmoto8, K. Rukrungtham9, P. Phanupak10 There are limited data guiding clinical care for HIV+ women in resource limited settings (RLS). We conducted this cross sectional study to examine associations between demographic, behavioral and clinical features and the presence or absence of cervical cytological abnormalities. |
| WePE0248 | ACCOMPANIMENT IS NOT ENOUGH: IMPROVING ACCESS TO MEDICAL CARE AND COMMUNITY SUPPORTS THROUGH COLLABORATIVE PARTNERSHIPS BETWEEN HOSPITALS AND COMMUNITY-BASED ORGANIZATIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0248 C. Moody1, J. Loudfoot1, J. Madsen2, L. Remund3 Hospital-based HIV clinics need to develop collaborative partnerships with community-based organizations to improve access to care for marginalized women. Comprehensive models of clinical HIV care should include outreach and address the social determinants of health. |
| WePE0249 | SEXUAL DYSFUNCTION IS NOT RELATED TO IMMUNOLOGIC STATUS IN HIV-INFECTED WOMEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0249 C.R. Fumaz1, J.A. Muñoz-Moreno1, J.L. Méndez2, M.J. Ferrer3, R. López-Blázquez4, E. Negredo3, G. Gómez4, A. Tarrats3, B. Clotet5 Sexual dysfunction, especially loss of libido, is present in a very high number of HIV-infected women. These disturbances are not associated with the immunologic status of the patients. Specific interventions for women to cope with these dysfunctions are recommended. |
| WePE0250 | UKRAINE: WHAT DO PROVIDERS KNOW ABOUT PMTCT? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0250 I. Mogilevkina1, C. Kramer2, J. Winkler2, A. Bishop2, K. Stekhin1 There are major gaps in providers' knowledge of HIV/AIDS and PMTCT. Many providers did not have correct knowledge of HIV transmission methods and MTCT. There is a need to provide adequate training in different aspects of HIV/AIDS and PMTCT in Ukraine. |
| WePE0251 | IMPORTANCE OF PATIENT-PROVIDER RELATIONSHIP TO RECEIPT OF AND ADHERENCE TO ANTIRETROVIRAL THERAPY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0251 M.C. Beach, J. Keruly, R.D. Moore Patients' perception of being 'known as a person' is strongly and independently associated with receiving and adhering to HAART, and having undetectable HIVRNA. Efforts to improve adherence and health of persons with HIV should focus on improving the patient-provider relationship. |
| WePE0252 | HEALTHCARE SEEKING BEHAVIOR FOR STI/HIV IN YOUNG POPULATIONS IN LOW-INCOME PERUVIAN COMMUNITIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0252 J.M. Girón1, X. Salazar1, M.R. Gárate1, C. Cáceres1, T. Coates2, NIMH Collaborative HIV/STD Prevention Trial Group The lack of risk perception within these populations complicates their access to health services and increases their vulnerability to STI/HIV infection. There are socio-cultural barriers within the population studied and among the healthcare providers that impede the populations' access to STI/HIV care, limiting the efficacy of prevention efforts combating the STI/HIV. |
| WePE0253 | PREVALENCE AND PATIENT AWARENESS OF MEDICAL COMORBIDITIES IN AN URBAN AIDS CLINIC Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0253 J. Weiss1, G. Osorio1, E. Ryan1, K. Barboza2, J. Pettersen3, S. Marcus1, D. Fishbein3 Mortality in patients with HIV infection is increasingly due to non-HIV related medical comorbidities. Data is lacking on the prevalence of medical comorbidities and subsequent accuracy of patient awareness. |
| WePE0254 | PERFORMANCE ASSESSMENT OF THE MOS-HIV HEALTH SURVEY IN HIV-INFECTED INDIVIDUALS IN ENTEBBE, UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0254 A. Medina Lara1, B. Nyanzi Wakholi2, P. Munderi2, C. Watera2, C.F. Gilks3, H. Grosskurth2, on behalf of the DART Trial Team2 Our results demonstrate the feasibility of assessing quality of life in HIV-infected individuals using the Luganda version of the MOS-HIV. Further work using repeated measure designs is underway to identify the sources of variability of responses in those dimensions that were found unreliable in this study. |
| WePE0255 | FAMILY PERCEPTIONS OF QUALITY OF CARE AND HIV RELATED STIGMA IN A NUTRITION REHABILITATION UNIT IN LILONGWE, MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0255 P. Fergusson1, K. Chikaphupha2, Y. Sitima2, J. Chinkhumba3, G. Nyirenda3, G. Bongololo2, I. Makwiza2, L. Nyirenda2, S. Theobald4 Provision of more holistic family care, where carers are educated about and involved in the care plan development and implementation for both HIV-infected and uninfected malnourished children could help to improve quality of life and care outcomes in NRUs. |
| WePE0256 | USING CLUSTER ANALYSIS TO DESCRIBE PEOPLE LIVING WITH HIV'S SYMPTOM EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0256 T. Lindgren1, D. Wantland1, W. Holzemer1, I. Corless2, E. Bunch3, J. Kemppainen4, L. Eller5, C. Coleman6, K. Kirksey7, Y.-F. Tsai8, P. Nicholas2, K. Nokes9, P. Dole10, M.J. Hamilton11, E. Sefcik11, G. Canaval12, N. Reynolds13, M. Rivero14 These symptom data support the need for further research on multiple symptom experience and highlight the need for interdisciplinary programs to help PLWAs better manage multiple symptoms. |
| WePE0257 | MAKING HIV TREATMENT MORE EFFECTIVE, THE ROLE OF PLHA IN VIET NAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0257 D.T. Thuy, N.T. Hang A peer system of networked self-help and support groups is the most effective way to transfer information to PLHA and maximize treatment benefits. PLHA peer treatment activities compliment and enhance HIV/AIDS medical and other health care services. |
| WePE0258 | HEALTH LITERACY, HEALTH OUTCOMES, AND HEALTHCARE SERVICE USE IN HIV+ PERSONS IN THE UNITED STATES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0258 K. Nokes1, M. Cashen2, C. Coleman3, P. Dole4, E. Sefcik5, M.J. Hamilton5, K. Kirksey6, E. Huang7, A. Jumpamool8, W. Holzemer7 Health literacy has been described as a continuum beginning with functional health literacy and moving to communicative/interactive health literacy and critical health literacy. While the REALM measures functional health literacy, no instruments are available to assess broader definitions of health literacy. This cross-sectional research raised more questions than it answered since persons with higher health literacy reported poorer health outcomes and there were no differences in use of healthcare services. This unanticipated finding requires further exploration. |
| WePE0259 | EXPANDING THE SUPPORT NEEDS PROFILE OF LONG-TERM SURVIVORS: IMPLICATIONS FOR AGENCIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0259 C. Leaver, A. Demetrakopoulos, Y. Perreault, B. Ellison The range of LT-survivor responses indicates significant impact of AIDS-related multiple loss on several key areas of marginalized identity and social isolation. Results also suggest that ASO support service delivery models are not currently addressing the complex dimensions of long-term survivorship. LT-Survivors themselves are best positioned to advise the creation of new support service profiles that are relevant to their needs, in accordance with GIPA principles. |
| WePE0260 | PERCIEVED CHANGES AND CHALLENGES IN THE QUALITY OF LIFE OF HIV-INFECTED INDIVIDUALS ON ART: A QUALITATIVE STUDY IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0260 B. Nyanzi-Wakholi1, A. Medinar Lara2, P. Munderi3, C. Gilks4, H. Grosskurth5 It should not be assumed that effective ART provision is sufficient in itself to lead to a major improvement of the perceived quality of life among persons living with HIV/AIDS. Good counselling and other additional support services may be required to consolidate the positive effects of ART. |
| WePE0261 | TRUST AS A PREDICTOR OF HAART SWITCHING AND DISCONTINUATION AMONG HIV+ WOMEN IN THE WOMEN'S INTERAGENCY HIV STUDY (WIHS) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0261 A.L. Boore1, E.T. Golub1, C. Cunningham2, T.E. Wilson3, S.J. Gange1 Many anecdotes about the influence of trust and beliefs on HIV care have been reported, but our prospective investigation quantifies the impact of beliefs on subsequent HAART modification. Our results, with even a limited measure of trust, suggest that further research may elucidate an important barrier to appropriate use of therapy. |
| WePE0262 | FURTER VALIDATION OF THE MCGILL QOL QUESTIONNAIRE: THE IMPORTANCE OF QUALITY OF LIFE IN PATIENT PERSPECTIVE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0262 P. Leombruni1, G. Orofino2, L. Lavagnino1, M. Bolgiani1, M. Guastavigna1, A. Picardi3, P. Caramello2, S. Fassino4 Our study contributed to building evidence of reliability and validity for the MQOL questionnaire, which may be particularly useful to assess the existential aspects of QOL that are particularly relevant to understand the HIV patients perspective on his disease and care. |
| WePE0263 | TO TELL OR NOT TO TELL: WHY PEOPLE WITH HIV SHARE OR DON'T SHARE WITH THEIR PHYSICIANS WHETHER THEY ARE TAKING THEIR MEDICATIONS AS PRESCRIBED Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0263 H. Kremer, G. Ironson A significant proportion of patients are not taking their medications as prescribed without telling their physicians. To facilitate the chance that patients communicate with their physicians, physicians need to ask them, and while giving the patients medical information, create a non-judgmental, respectful atmosphere where patients feel comfortable sharing their personal view. |
| WePE0264 | IS PATIENTS' PREFERRED INVOLVEMENT IN HEALTH DECISIONS RELATED TO OUTCOMES FOR PATIENTS WITH HIV? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0264 M.C. Beach, R.D. Moore Although previous research suggests that more patient involvement in health care decisions is better, this benefit may be reduced when the patient does not want the provider to be involved. Future research should explore the extent to which this preference is modifiable so as to improve outcomes. |
| WePE0265 | USING HAART: UNCERTAINTIES AND EXPECTATIONS IN THE HIV TREATMENT EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0265 M. Davis1, P. Flowers2, J. Frankis3 These themes are discussed for their psychosocial implications. In particular, technological horizon provides a basis for the management of uncertainties in the prescribing relationship between patient and clinician. |
| WePE0266 | AN ASSESSMENT OF PATIENT AND STAFF SATISFACTION WITH SERVICES AT AN HIV/AIDS CARE AND TREATMENT CLINIC IN NAMPULA, MOZAMBIQUE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0266 P.W. Young1, B. Elul2, D. Winchell3, D. Arakaki-Sanchez4, R. Fernandes3, M. Rosenthal1, D. Nash2 The study revealed untapped ideas about how to improve quality of HIV care, which could be implemented in partnership with patients and staff. Satisfaction studies provide a complementary measure of service quality and should be expanded in resource-poor settings. |
| WePE0267 | EVALUATING THE DYNAMICS OF CARE IN COMPREHENSIVE SERVICE DELIVERY MODELS FOR PEOPLE LIVING WITH HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0267 B. Rapkin1, E. Weiss1, R. Chhabra2, L. Ryniker1, H. Moran3, J. Carness1, S. Gulati1, R. Adsuar1, J. DeLorenzo4, E. Tanner4, C. DeLaMarter4, W. Kahalas4, I. Feldman4 This multi-dimensional assessment was successful in distinguishing problem resolution from satisfaction with care, and in identifying help seeking differences between groups. Results indicate the utility of this approach in evaluating comprehensive public health programs. |
| WePE0268 | INJECTABLE THERAPY IN HIV: THE ROLE OF PHYSICIAN AND PATIENT ATTITUDES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0268 R. Horne1, V. Cooper1, C. Tsoukas2, C. Katlama3, C. Cohen4, J. Slim5, C. Fumaz6, C. Kovacs7, M. Fisher8, J.R. Arribas9, P. Shalit10, R. Kulasegaram11, B. Clotet6, J. Vera12, K. Arastéh13, M. Youle14 Physician inherent beliefs about injectable therapy are important predictors of prescribing behaviour while patient beliefs are predictors of reactions to a treatment offer. These data suggest a disconnect between physician and patient beliefs, with patients having more positive attitudes towards injectable ARVs than anticipated by physicians. |
| Track C – Epidemiology, Prevention and Prevention Research | |
| WePE0269 | INCIDENCE OF MATERNAL HIV SEROCONVERSION DURING PREGNANCY IN 10 OF THE UNITED STATES, 1999-2001 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0269 S. Sansom, N. Ruffo, M. Campsmith Maternal seroconversions during pregnancy may be one important cause of the remaining perinatal HIV transmissions in the US. New perinatal HIV screening guidelines are expected to strengthen recommendations for a repeat HIV screen late in pregnancy. |
| WePE0270 | TIMING OF DIAGNOSIS OF HIV INFECTION IN INFANTS IN NEW YORK STATE (NYS) 1997 - 2004 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0270 W. Pulver1, L. Smith1, K. Li1, B. Warren2, T. Sullivan3, G. Birkhead2 Caution is warranted in changing the 4-month standard length of follow-up of HIV-exposed infants for exclusion of HIV infection, given late (-) PCR results in confirmed infected infants. |
| WePE0271 | THE CONTRIBUTION OF INFECTION ACQUIRED DURING PREGNANCY TO RESIDUAL MOTHER-TO-CHILD HIV TRANSMISSION RATES IN NEW YORK STATE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0271 G. Birkhead, E. Kowalski, S. Hackel, W. Pulver, R. Glaros, B. Warren Federal and state policy makers should review repeat testing and treatment recommendations in light of the high contribution of infection during pregnancy to residual MTCT. Clinicians should maintain a high level of suspicion for acute HIV infection when a pregnant women presents with a compatible clinical syndrome. Continued prevention messages are important for pregnant women testing negative during the pregnancy. |
| WePE0272 | EVALUATION OF HIV SCREENING IN PREGNANCY IN ONTARIO, CANADA, 1999-2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0272 R. Remis1, C. Swantee2, R. Palmer1, K. Wu2, M. Fisher2, S. King3, C. Major2, E. Whittingham1, M. Fikre Merid1 HIV test uptake increased dramatically following the change in policy, in part due to the memo described above. Actual HIV test uptake in 2005 is probably closer to 88% taking into account incomplete record linkage. In 2002, HIV positivity among untested pregnant women was twice that of tested women; though 77% of pregnant women were tested, only 62% of HIVinfected women were tested. Based on the observed HIV incidence, an estimated 133 women of childbearing age are infected annually in Ontario; this is consistent with modelled estimates. |
| WePE0273 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0273 Abstract not available |
| WePE0274 | THE CANADIAN PERINATAL HIV SURVEILLANCE PROJECT (CPHSP): CHANGES IN DEMOGRAPHICS AND HIV TRANSMISSION RATES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0274 L. Samson1, J. Forbes2, A. Alimenti2, J. Singer3, D. Money2, N. Lapointe4, Canadian Pediatric AIDS Research Group The proportion of MIP that received ART has doubled and infection rate has decreased by 75%. The effectiveness of perinatal ART and management is reflected in greater use of perinatal combination ART and decreased infection rates. The CPHSP helps to identify demographic changes within the Canadian HIV epidemic. This helps to develop appropriate programmatic responses. Ongoing efforts must ensure infected pregnant women are identified and receive appropriate combination ART. |
| WePE0275 | HIV/AIDS ESTIMATES IN ETHIOPIA, TRENDS AND PROGRAMMATIC CHALLENGES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0275 S. Ismail1, A. Woldu2, W. Hladik3, J. Ahmed1, T. Wuhib4 The proportion of MIP that received ART has doubled and infection rate has decreased by 75%. The effectiveness of perinatal ART and management is reflected in greater use of perinatal combination ART and decreased infection rates. The CPHSP helps to identify demographic changes within the Canadian HIV epidemic. This helps to develop appropriate programmatic responses. Ongoing efforts must ensure infected pregnant women are identified and receive appropriate combination ART. |
| WePE0276 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0276 Abstract not available |
| WePE0277 | POSSIBLE WAR EFFECT ON TRENDS OF HIV-1 AND HIV-2 PREVALENCE AMONG PREGNANT WOMEN IN GUINEA-BISSAU, WEST AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0277 F. Månsson1, A. Alves2, Z.J. Da Silva3, F. Dias3, S. Andersson4, G. Biberfeld5, E.M. Fenyö6, H. Norrgren1 There has been a significant shift in prevalence rates of HIV-1 and HIV-2 in women giving birth at the maternity ward in the National Hospital Simão Mendes in Bissau. This trend is similar to observations in other groups in Guinea-Bissau. After the civil war in 1998-1999 there was a sharp rise in HIV-1 prevalence observed among pregnant women in Bissau and we can not rule out at least a partial effect of the civil war. |
| WePE0278 | HIV AND HEPATITIS VIRUS CO-INFECTIONS AMONG ZAMBIAN MILITARY MEN AND WOMEN: IMPLICATIONS FOR PRE-ARV HEPATITIS SCREENING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0278 P.D. Njobvu1, A.P. Mulela2, C.M. Sakala3, Z.T. Nyirenda4, J.S. Banda5 These findings suggest that hepatitis and HIV infections are occurring independently in this population and that routine pre-ARV HBV and HCV screening would not be cost-effective owing to low rates of active infection. |
| WePE0279 | INCIDENCE OF OPPORTUNISTIC INFECTIONS (OIS) WITHIN SPECIFIC CD4 STRATA IN HIV-INFECTED PATIENTS IN SOUTHERN INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0279 B. Wang1, N. Kumarasamy2, N. Divi3, A. Cecelia2, K. Mayer4, Z. Lu3, L. Wolf3, T. Flanigan4, M.C. Weinstein5, R.P. Walensky3, K. A. Freedberg3, E. Losina6 The CD4-specific risk of OIs in HIV-infected adults in Southern India varies widely, with tuberculosis being the most frequent severe OI. These results can be used to understand the implications of different OI prophylaxis and antiretroviral treatment decision thresholds. |
| WePE0280 | CHALLENGES FOR COLLABORATIVE TUBERCULOSIS AND HIV SURVEILLANCE IN HIGH PREVALENCE SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0280 L.J. Nelson1, K.W. Stinson1, B. Kim1, A. Miranda2, C.D. Wells1 TB and HIV programs should collaborate to collect TB/HIV data; additional resources may be required. CDC has developed TB/HIV surveillance and Diagnostic HIV CT training curricula to assist with this process. |
| WePE0281 | FREQUENCY OF AND FACTORS ASSOCIATED WITH TUBERCULIN SKIN TESTING AMONG HIV-INFECTED PERSONS IN THE U.S., 2000-2003 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0281 E. Teshale, D. Hanson, S. Marks, A.D. McNaghten, P. Sullivan Although 70% of HIV-infected persons in ASD had ever received a TST, implementation of USPHS/IDSA guidelines for annual TST was quite low. TST should be offered annually to eligible persons and LTBI treatment prescribed for TST-positive persons to prevent TB disease and reduce TB transmission. |
| WePE0282 | TRENDS IN HIV AND AIDS IN PORTUGAL: NEW OPPORTUNISTIC INFECTIONS? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0282 M.T. Paixão1, H. Cortes Martins1, E. Pádua1, M.H. Ângelo2 The increase of heterosexual HIV transmission and the high incidence of AIDS defining illnesses may account for the stable HIV/AIDS incidences, in spite of the declining trend of IVDU HIV/AIDS cases and tuberculosis, due to aggressive prevention/therapeutic policies. |
| WePE0283 | STUDY OF VCTCS (VOLUNTARY COUNSELLING AND TESTING CENTRES) FOR THE DETECTION TUBERCULOSIS IN MAHARASHTRA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0283 V.S. Singh Establish an effective system of cross reference between HIV/AIDS and TB control centres by training the staff of VCTCs, TB microscopy centres and DOTs. |
| WePE0284 | HIV-1 IN LUXEMBOURG, 2001-2005: PREDOMINANCE OF NON-B HIV-1, IDENTIFICATION OF A B/F UNIQUE RECOMBINANT FORM (URF) OUTBREAK AND EMERGENCE OF DRUG RESISTANT VARIANTS IN NEWLY DIAGNOSED PATIENTS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0284 D. Struck1, F. Roman1, D. Gonzalez2, C. Lambert1, J.-Y. Servais1, V. Etienne1, T. Baurith1, T. Staub3, V. Arendt3, R. Hemmer3, J.-C. Schmit4 During the past five years, non-B HIV-1 was responsible for the majority of newly diagnosed infections in Luxembourg. Drug-resistant variants were significantly more prevalent in treatment-naïve, newly diagnosed patients. Our results show the increasing molecular complexity of HIV in our country which should be taken into account when interpreting molecular biology assays and initiating ART. |
| WePE0285 | LONGITUDINAL SURVEY OF ANTIRETROVIRAL DRUG RESISTANCE IN UNTREATED PATIENTS FROM ABIDJAN, CÔTE D'IVOIRE: DATA FROM 2002 TO 2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0285 T.d. Toni1, B. Masquelier2, A. Minga3, Y. Abo3, A. Coulibaly3, H. Chenal4, F. Dabis5, R. Salamon5, H. Fleury2, Primoci-Pacci Study Group CRF02-AG recombinant is predominant in Côte d'Ivoire despite circulation of intersubtype recombinants. The most important conclusion of our study is the circulation of strains with key drug resistance mutations in untreated patients from Côte d'Ivoire at a significative frequency (more than 5%, threshold for WHO). These data confirm the necessity to maintain this survey in a context of wider distribution of ARV. |
| WePE0286 | PMTCT PROGRAM PROGRESS AT UNIVERSITY OF NORTH CAROLINA (UNC) PROJECT, LILONGWE, MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0286 E. Kamanga1, M. Innocent1, F. Martinson1, D. Chilongozi1, M. Tembo1, G. Mwale1, J. Murotho1, Z. Mhango1, C. Matiki1, P. Kanduku1, I. Hoffman2, C. van der Horst2 We recommend that PMTCT programs be fully incorporated into all antenatal services in Malawi. Our program has demonstrated an increase in PMTCT, overall HIV risk reduction education, HIV VCT acceptance rate and nevirapine uptake. However, the program must be expanded to include home administration of infant nevirapine dosing by traditional birth attendants. |
| WePE0287 | RESISTANCE TO ANTIRETROVIRAL THERAPY IN PATIENTS WITH HIV-1 INFECTION IN CHILE, 2002-2004 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0287 A. Afani1, C. Beltran2, Orellana L, Duarte P, Acevedo W,Vasquez P, Wolf M. This is the first Chilean study to describe the mutational patterns associated with resistance in antiretroviral treated individuals with virologic failure diagnosis. Remarkably, five mutations were found in the majority of HIV strains included in the analysis. This data provides important information about the molecular epidemiology of drug resistance mutations and its application in the design of new strategies of effective HAART. This study will be extended, since the prevalence of resistance may experience changes over time. |
| WePE0288 | PREVALENCE OF HIV-1 ANTIRETROVIRAL DRUG RESISTANCE IN 3 SMALL BRAZILIAN CITIES WITH ESTABLISHED LOCAL HIV/AIDS PROGRAMS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0288 W.A. Eyer-Silva, M.G. Morgado The relatively low prevalence of resistance mutations in these cohorts seem to argue against the concern that resource-poor settings should not implement widespread accessibility to standard of care HAART combinations due to the possibility of sub-optimal adherence leading to the emergence and spread of drug-resistant strains. Continued surveillance on the prevalence of resistant strains in inner Brazil will be needed. |
| WePE0289 | LOW RATE OF TRANSMISSION OF DRUG RESISTANCE HIV AMONG RECENTLY-INFECTED BLOOD DONORS IN BANGKOK, THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0289 S. Sirivichayakul1, R. O-Charoen2, K. Ruxrungtham1, D. Sutherland3, P. Phanuphak4 Transmission of HIV with drug resistance genotype has been increasingly reported worldwide, especially in the Western world. Wider access of ARV in Thailand according to the policy of the Thai government poses a concern on the transmission of drug resistant virus. |
| WePE0290 | GENOTYPIC RESISTANCE PROFILE BEFORE INITIATION OF CART AND ASSOCIATION WITH VIROLOGICAL AND CLINICAL OUTCOME IN EUROSIDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0290 W.P. Bannister1, A.N. Phillips1, B. Clotet2, P. Reiss3, B. Ledergerber4, A. Lazzarin5, C. Katlama6, A. Cozzi-Lepri1, L. Ruiz2, J.D. Lundgren7, EuroSIDA The prevalence of DRMs observed in antiretroviral-naïve EuroSIDA patients is consistent with other large European cohorts. There was no evidence of an association between pre-cART DRMs and virological or clinical outcomes, although analyses had limited power. |
| WePE0291 | EPIDEMIOLOGY OF HIV-1 SUBTYPES AND DRUG RESISTANCE IN PATIENTS FAILING ANTIRETROVIRAL THERAPY FROM RIO DE JANEIRO, BRAZIL: AN UPDATE (2002-2005) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0291 J.C. Couto-Fernandez1, S.M. Oliveira2, P.J.N. Chequer2, M. Morgado1 The genetic data obtained through the HIV-1 resistance genotyping, could be useful in molecular epidemiology studies in Brazil. A clear association between HIV-1 subtypes and drug resistance mutations was observed in this study In addition, the maintenance of HIV-1 genotyping programs have substantially contributed to the management of new ARV therapies in failure patients from Rio de Janeiro, Brazil. |
| WePE0292 | ENABLING THE COMMUNITY TO ACCESS VCT AT THEIR DOORSTEPS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0292 R. Anbu Rajan Voluntary Counseling and Testing facilities were promoted aiming at enabling the people to know their HIV status at an early stage and take steps to live positively. As most of the existing VCTs are urban based and institutionalized, they were not accessed by the people from the rural and remote areas. |
| WePE0293 | FORMAL AND INFORMAL HIV TRANSMISSION RISK REDUCTION STRATEGIES AMONG 3,818 HIV-INFECTED PERSONS IN 4 CITIES IN THE UNITED STATES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0293 E.D. Charlebois, W.T. Steward, S.F. Morin, NIMH Healthy Living Project Study Group Evidence for the use of different formal strategies was apparent for women, HTM and MSM. Evidence for the informal strategy of HIV sero-sorting was strongest for MSM. |
| WePE0294 | DETERMINANTS OF PREGNANCY AMONG WOMEN RECEIVING HAART IN RURAL UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0294 J. Homsy1, R. Bunnell1, R. King1, R. Nakityo1, D. Glidden2, D. Moore1, B. Waiswa3, C. Likicho3, W. Were3, J. Mermin1 Most pregnancies in this cohort of women on HAART were unplanned or undesired. Supportive counseling and family planning services for both women and men should be integral to HAART interventions. |
| WePE0295 | POSTCARDS FROM THE 'EDGE': AN EFFECTIVE BEHAVIORAL INTERVENTION FOR INCREASING SAFER SEX AMONG HIV-POSITIVE MSM IN THE CONTEXT OF ONGOING METHAMPHETAMINE USE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0295 T.L. Patterson1, B. Mausbach1, S.J. Semple1, J. Zians1, S. Strathdee2 We demonstrated the ability to significantly reduce high risk sexual behaviors among HIV-positive MSM in the context of ongoing methamphetamine use using a novel, theory-based behavioral intervention that has application for scaling-up in community-based settings. |
| WePE0296 | SELF-EFFICACY AMONG HIV-POSITIVE PATIENTS: RESULTS FROM A PREVENTION IN-CARE INITIATIVE IN THE UNITED STATES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0296 S.N. Patel1, C.E. Golin2, L. Tsui-Shan3, H. Tien3, Z. Chariyeva4, M. Thompson5, M. Thrun6, T. Wilson7, A. Timmons7, A. Yale6, J. Clemons5, E.B. Quinlivan8, J. Wright9 Percent changes in scores on self-efficacy increased among people living with HIV from baseline to six months. Although we cannot stratify yet by dose of provider intervention received, 12 month follow-up and dose collection are underway and may strengthen our conclusions. |
| WePE0297 | A QUESTIONNAIRE SURVEY ON HIV TESTING TO MOTHERS WITH INFANT AGED 6-24 MONTHS IN CAMBODIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0297 Y. Sasaki1, S. Ou2, K. Koum2, S. Vong2, A. Moazzam1, K. Kakimoto3, C. Kuroiwa1 Although most of the mothers required the permission of their husband, the majority of the tested mothers seemed to understand benefits of HIV testing and basic information on HIV/AIDS. In order to increase the acceptability of HIV testing, benefits of the test for the child and the mothers should be more informed to not only mothers also their husbands through PMTCT activities including IEC strategies. |
| WePE0298 | SEXUAL BEHAVIOR AND SEXUALLY TRANSMITTED INFECTIONS AMONG HIV-1-INFECTED MSM IN PERU Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0298 J.R. Lama1, P. Goicochea1, A. Laguna2, J. Sanchez3, M. Pun4, L. Suarez4, W. Whittington5, C. Celum5, J. Sanchez1 Some evidence of HIV "serosorting", high STI prevalences and high proportion of reported risk sexual behavior are present among HIV-infected MSM in Peru. Strategies promoting awareness of HIV serostatus and risk reduction counseling for those men with HIV diagnosis are needed to be reinforced. |
| WePE0299 | ASSOCIATIONS BETWEEN UNPROTECTED ANAL INTERCOURSE AND SUBSTANCE USE BEFORE AND AFTER HIV DIAGNOSIS AMONG RECENTLY HIV-INFECTED MEN WHO HAVE SEX WITH MEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0299 L. Drumright1, S. Strathdee1, S. Little2, M.R. Araneta1, D. Slymen3, V. Malcarne4, E. Daar5, P. Gorbach6 Use of specific recreational substances may be differentially associated with UAI based on knowledge of HIV status. These findings have implications for both prevention of high risk sexual behavior and substance use among recently HIV-infected MSM. |
| WePE0300 | DEMOGRAPHIC AND BEHAVIORAL CHARACTERISTICS OF RECENTLY HIV-INFECTED INDIVIDUALS WITH RESISTANT VIRUS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0300 P.M. Gorbach1, L. Drumright2, S. Frost3, E.S. Daar4, S.J. Little5 Behavioral factors and types of partnership were not associated with acquisition of drug resistant HIV in this relatively small cohort of Southern Californian recently HIV-infected MSM. In contrast, the higher prevalence of drug resistant virus among Latinos suggests risks may vary by sexual networks. Further study using different assessments of drug resistance such as genotype and with larger samples is needed to fully define factors associated with acquisition of drug resistant HIV. |
| WePE0301 | WHAT DOES IT TAKE TO INTEGRATE HIV PREVENTION AND CARE? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0301 K. Koester, A. Maiorana, K. Vernon, J. Myers, C. Dawson Rose, S. Morin When designing and implementing prevention activities it is important to take into account the clinic culture, existing practices, and services. Developing interventions that resonate with the target population and the clinical environment will lead to a greater willingness from and meaningful experience for, participants. |
| WePE0302 | TELLING CHILDREN LEFT BEHIND ABOUT HIV: MIGRANT AFRICAN HIV POSITIVE PARENTS IN ENGLAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0302 C. Martha, M. Livingstone Important to recognise the implications of trans-national family life on public health in particular the health of children left behind. |
| WePE0303 | PROJECT SAFETALK: AN INNOVATIVE MULTI-COMPONENT MOTIVATIONAL INTERVIEWING-BASED SAFER SEX PROGRAM FOR PEOPLE LIVING WITH HIV (PLWH) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0303 C. Golin1, S. Przybyla2, B. Fowler2, S. Patel2, J. Earp2, S. Parker2, R. Davis2 We have developed an acceptable and useful multi-component program to conduct safer sex counseling among PLWH. We will test its effect on behavior among 500 PLWH. |
| WePE0304 | FACTORS RELATED TO THE SEXUAL BEHAVIOR OF HIV-POSITIVE INDIVIDUALS IN UGANDA: FINDINGS FROM QUANTITATIVE AND QUALITATIVE INQUIRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0304 J. Lifshay1, O. Grinstead2, F. Babirye3, C. Kazibwe4, A. Coutinho5 In addition to individual factors, social and structural factors must be taken into account in the development of risk reduction interventions for HIV-positive individuals. Qualitative data can contextualize quantitative findings and both are useful when studying complex health behaviors. |
| WePE0305 | NARRATIVE ONLINE: BUILDING AN INTERNET SITE TO SUPPORT PEOPLE LIVING WITH HIV Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0305 D. Ridge1, S. Zieblandx2, J. Anderson3, I. Williams4, J. Elford1 It is recommended that the feasibility of using the DIPEx HIV website to support people with HIV and their carers be examined using exploratory, qualitative research before conducting large-scale controlled trials. |
| WePE0306 | SEX PRACTICES AND HIV-SEROSTATUS DISCLOSURE AMONG HIV-INFECTED PERSONS RECEIVING HAART IN GUYANA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0306 A. Florendo1, N. Kishun1, K. Ramcharran2, R. Samlall2, J. Raghunauth3, N. Persaud4 Persons on HAART in Guyana were more likely to disclose their HIV status to a family member than their sex partners. A high proportion of HIV positive persons continue to practice unsafe sex. |
| WePE0307 | FACTORS RELATED TO SUICIDAL IDEATION OF PLWHAS IN THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0307 P. Uthis As hypothesized, sex, economic status, sexual orientation, stage of disease, social support, stigma, family relationships, coping response, and history of family suicidal behavior were found to be factors related to suicidal ideation of PLWHAs in Thailand. Whereas, age, education, marital status, mental illness, period of blood examination known, mental illness, and substance used were not significantly related to suicidal ideation. |
| WePE0308 | IMPACT OF HIV DISCLOSURE BY MULTIDISCIPLINARY APPROACH. PILOT STUDY AT SIRIRAJ HOSPITAL, BANGKOK, THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0308 U. Kottapat1, V. Boon-yasidhi2, W. Prasitsuebsai1, N. Vanprapar1, K. Chokephaibulkit1 Preliminary results from the multidisciplinary approach were encouraging for disclosure. The guidelines for disclosure are needed to assist the team in conducting the standardized process. |
| WePE0309 | ANALYSIS OF THE BASELINE SURVEY ON ACCESS TO INFORMATION, KNOWLEDGE, ATTITUDE, AND PRACTICES, RELATED TO HIV/AIDS AMONG DIRECT SEX WORKERS (DSW), INDIRECT SEX WORKERS (IDSW), HOUSEHOLD MALE (HHM) AND HOUSEHOLD FEMALE (HHF) IN CAMBODIA, 2004 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0309 S. Sarun1, V. Saphonn2, T. Plipat3, C.V. Mean4 Since more than half of HHM and HHF never received HIV/AIDS information, HIV prevention program should develop strategies to reach general population. TV, radio and outreach was the good way to deliver HIV/AIDS information. A large proportion of general population has expressed their willingness to test for HIV. It is therefore urgent to expand a good quality voluntary testing center to meet these needs. |
| WePE0310 | ILLICIT DRUG USE IS REDUCED FOLLOWING A VIDEO DOCTOR INTERVENTION DESIGNED FOR HIV CARE SETTINGS: A RANDOMIZED CONTROLLED TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0310 D. Danley1, P. Gilbert1, S. Gansky2, D. Ciccarone3, D. Bangsberg4, B. Gerbert1 Drug use may harm HIV-positive patients' health. Patients who received the video doctor intervention reported less frequent drug use at follow-up, and many reported not using drugs. Program effects may be greater for methamphetamine use than for cocaine. |
| WePE0311 | DEMOGRAPHIC CHARACTERISTICS, BEHAVIORS, KNOWLEDGE OF STI AND ACCESS TO STI TREATMENT, AMONG HIGH RISK GROUPS (HRGS) IN RAWALPINDI, PAKISTAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0311 N. Saleem1, A. Razaque2, A. Altaf3, A. Adrien4 Different levels of knowledge of STI, and risky behaviors exist among various HRG. |
| WePE0312 | UNSAFE SEX RATES OF HIV POSITIVE MSM IN THE USA: RESULTS OF THE POSITIVE CONNECTIONS TRIAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0312 B.R.S. Rosser1, J.L. Peterson2, S.M. Jacoby1, M. Miner1, S. Welles3, L.A. Hatfield1, the Positive Connections Team The Positive Connections Trial has recruited one of the largest samples of HIV+ MSM of Color into an HIV prevention study in the USA. We attribute success in recruitment to strong HIV+ MSM involvement, excellent AIDS Service Organization outreach, and good community-university collaboration. Data on the sexual risk behavior of HIV+ MSM compared by race/ethnicity of subjects, to be reported at the conference, should inform both infection patterns and intervention planning in USA epicenters. |
| WePE0313 | SEX RISKS IN HIV POSITIVE INDIVIDUALS IN BUENOS AIRES, ARGENTINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0313 E. Valverde1, I. Cassetti2, L. Metsch1, A.C. Camarotti3, L. Bofill1, G. Bugarin2, M. Laurido2, C. McCoy1 A significant number of participants in this study reported inconsistent condom use reflecting limited understanding of safe sex behavior practices. Educational programs targeting HIV positive individuals are necessary to increase understanding of the risks of inconsistent condom use. It is important to assess for depression, and refer to treatment patients reporting severe symptoms of depression, plus provide them with sex risk reduction counseling. |
| WePE0314 | FEASIBILITY AND ACCEPTABILITY OF USING AN INNOVATIVE PICTURE-BASED, AUDIO-ASSISTED, INTERACTIVE COMPUTER TECHNOLOGY TO COLLECT SEXUAL TRANSMISSION RISK INFORMATION IN THE CONTEXT OF PROVIDING ANTIRETROVIRAL THERAPY TO HIV PATIENTS IN A LOW LITERACY SETTING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0314 K. Zeller1, R. Pawinski2, N.R. Gandhi3, A. Moll4, A. Lalloo2, G. Friedland5 This technology provides a feasible and acceptable tool for assessing sexual transmission risk behavior in literacy limited resource-constrained settings. |
| WePE0315 | STIGMATIZATION AND ADHERENCE TO HAART AMONG TWO COHORTS OF HIV POSITIVE PATIENTS IN BAMAKO AND OUAGADOUGOU Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0315 A. Ngamini Ngui1, M.V. Zunzunegui1, C. Boileau1, S. Ag Aboubacrine2, P. Niamba3, M. Sylla4, S. Rashed1, V.K. Nguyen1 Perceived stigma is more frequent among the most vulnerable segments of the population and appears to add barriers to adequate treatment adherence. Interventions that stimulate a dialogue around the issue of stigma may improve adherence to treatment in this setting. |
| WePE0316 | COMPARISON OF COGNITIVE PERFORMANCE OF ASYMPTOMATIC HIV-1 SEROPOSITIVE INDIVIDUALS AND CONTROLS FROM SOUTH INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0316 K. Gopukumar1, S.L. Rao2, P. Satishchandra3, J. Dasgupta4, F. Wilkie5, D. Waldrop-Valverde5, D.K. Subbakrishna6, A. Desai7, V. Ravi7, B.S. Rao8, K.S. Satish8, M. Kumar5 It can thus be concluded that asymptomatic HIV-1 seropositive subjects with Clade C virus have mild psychomotor slowing which is not severe enough to cause impairment in the day to day functioning of the individuals. These minimal changes support clinical reports of slow disease progression, which is not severe enough to cause impairment in the day to day functioning of the individuals. |
| WePE0317 | VCT AND TREATMENT KNOWLEDGE, ATTITUDE AND PRACTICES OF HEALTHCARE PROVIDERS IN IMO STATE, NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0317 B. Nwanguma1, P. Nwanya2, I. Stella1 Capacity building and retraining are recommended to improve professional practice and attitudes of health professional especially towards HIV/AIDS patients. This will improve their perspectives on key aspects of HIV/AIDS management as counselling, VCCT, treatment and referrals. |
| WePE0318 | EFFICACY OF PROVIDER-LEVEL INTERVENTIONS IN PRIMARY CARE SETTINGS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0318 M. Lightfoot, M.J. Rotheram-Borus, V. Reddy, S. Comulada, R. Weiss Few interventions have been designed and evaluated for HIV-seropositive persons. Efficacious computer-based interventions to reduce the transmission risk behaviors can be successfully developed and implemented in sites where persons routinely visit, in a cost-efficient manner that does not require a high level of staff training or monitoring, important for implementation in resource poor settings. |
| WePE0319 | SCALE UP OF AIDS PREVENTION THROUGH FAMILY PLANNING SERVICE NETWORK IN HIV HIGH PREVALENT RURAL AREAS IN CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0319 Y. Cheng1, S. Xu2, X. Guo3, X. Wang3, Y. Cai3, Y. Lv3 The acceptability and feasibility of scale up of AIDS prevention through FPSN is very high, which has greatly spread AIDS knowledge, greatly increased level of knowledge, greatly increased the number of women participating in VCT, and greatly improved the knowledge and skill of condom use among husbands in HIV high prevalent rural areas in China. Scale up of AIDS prevention through FPSN will be favorable to promote the sustainability and availability of AIDS intervention in China. |
| WePE0320 | KABP SURVEY ON STDS AND HIV/AIDS AMONG THE FISHING COMMUNITY IN MUKONO DISTRICT UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0320 M. Muyonga Overall,the whereas the knowledge levels were high the behavioural change and heallth seeking behaviour was limited. |
| WePE0321 | CHARACTERISTICS OF FOREIGN BORN HISPANICS RESIDING IN THE US RECENTLY DIAGNOSED WITH HIV INFECTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0321 E. Valverde1, P. Anderson-Mahoney2, S. Strathdee3, C. Del Rio4 Foreign-born Hispanics living in the US benefited significantly from short-duration case management compared to a simple referral to HIV care, regardless of residency status. Although foreign-born Hispanics perceived they would experience significant HIV care discrimination, we saw no evidence of this in terms of their access to care. |
| WePE0322 | SEXUAL IDENTITY, SEXUAL BEHAVIOR, AND DISCLOSURE OF HIV-INFECTED AFRICAN-AMERICAN MEN IN A LARGE URBAN CLINIC IN DEKALB COUNTY, GEORGIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0322 M. Thompson1, J. Clemons1, M. Rajab2, K. Prince2, P. Campos3, The Project PREVENTS Study Team HIV+ AA men are more likely to disclose their HIV status to female partners who are believed to be HIV negative than those of unknown status. Condom use is higher with male and female HIV negative partners than those of unknown status. |
| WePE0323 | FROM PERSONAL SPACE TO COMMUNITY ACTION: YOUNG PEOPLE AND HIV/AIDS IN RURAL INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0323 F. Akhtar, D.D. Aggarwal This paper describes the challenges faced and lessons learnt in the process of changing attitudes of the young people, parents and stakeholders for creation of YICs to address HIV/AIDS in different cultural settings in rural India. |
| WePE0324 | A VOICELESS COMMUNITY - HIV/AIDS AND ZIMBABWE'S DEAF YOUTH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0324 J. Foster1, L. Foster2, G. Foster3 Obtaining information concerning HIV/AIDS from the deaf presents several challenges. Education is successful in increasing deaf people's knowledge and personal risk assessments though it is unclear whether it leads to positive persistent changes in sex behaviour. Greater investments in education, particularly using participatory techniques, and better understanding of HIV prevention of deaf people are needed. |
| WePE0325 | INTERNALIZED AIDS STIGMA, AIDS DISCRIMINATION, AND DEPRESSION AMONG MEN AND WOMEN LIVING WITH HIV/AIDS, CAPE TOWN, SOUTH AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0325 L.C. Simbayi1, A. Strebel1, A. Cloete1, N. Henda1, A. Mqeketo1, K. Magome2, S.C. Kalichman3 These results indicate an urgent need for social reform to reduce AIDS stigmas and the design of interventions to assist people living with HIV/AIDS to adjust and adapt to the social conditions of AIDS in South Africa. |
| WePE0326 | SEXUAL BEHAVIORS AMONGST HIV-INFECTED MALES AND FEMALES ATTENDING A TERTIARY REFERRAL CENTER FOR CLINICAL CARE AND TREATMENT IN A DEVELOPING COUNTRY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0326 E.N. Nnoruka1, J.C. Chukwuka2 This study identifies on going high risk sexual behaviors amongst a clinic based group of HIV-infected males and females. Secondary prevention interventions can therefore be undertaken as an integral aspect of clinical care in developing countries. |
| WePE0327 | STIGMA AND DISCRIMINATION ATTACHED TO HIV/AIDS IN DOTI DISTRICT OF NEPAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0327 N. Sharma, N. Pant Married women and young widows are most affected because many of them have lost their husbands to AIDS. They are stigmatized and discriminated by family, community and health institutions. They are desperately in need of sustained income sources to support themselves and the family. |
| WePE0328 | TOWARDS ALTERNATIVE MANAGEMENT STRATEGIES FOR HIV/AIDS, PLWHA AND PABHA IN AFRICA: A STUDY OF SELECTED COMMUNITIES IN NORTHWESTERN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0328 Y. Abdul-Azeez Since most respondents neither believed in the reality of HIV/AIDS nor subscribed to ABC strategy of HIV/AIDS prevention, neglecting the bottlenecks behind management of HIV/AIDS and PLWHA/PABHA stands to impede alternative outlets for emasculating HIV/AIDS and its consequences. |
| WePE0329 | ARE VCT CLIENTS SATISFIED WITH THEIR SERVICES? RESULTS FROM A CLIENT SATISFACTION SURVEY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0329 P. Modiba1, T. Motholo1, O. Manyana1, J. Sibeko1, J. Motloung1, S. Dlamini1, T. Coates2, J. McIntyre1, G. Gray1 User satisfaction of services is linked to the participatory nature of VCT provided. This could be linked to the fact that users felt valued and empowered in the counseling process. |
| WePE0330 | CARE SITUATION, MANAGEMENT AND ADJUSTMENT TO HIV/AIDS AMONGST PLWHA IN NIGER DELTA REGION OF NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0330 U. Omo - Obi1, P. Okoh1, R. Okoh1, A. Obioma2 PLWHA desired institutional support in the areas of medication, nutrition, socio-economic empowerment and pysco-care. Thus two useful psychological models; the Radley and Nichols system mainstreamed with occupational Behavioral therapy is presented for effective care management of PLWHA. Strengthening the capacity of care and service providers, socio-economics services and infrastructure is recommended. |
| WePE0331 | ROLE OF NEPAL RED CROSS SOCIETY IN REDUCING STIGMA AND DISCRIMINATION TOWARDS INFECTED AND AFFECTED BY HIV/AIDS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0331 P. Aryal1, K.C. Aryal2 Meaningful involvement of PLHAs is essential for organizing anti stigma and discrimination initiatives. Advocacy actions are vital tool to create supportive environment and protect rights of PLWHA. Programme has to be designed on the basis of holistic framework. |
| WePE0332 | ENHANCING COMMUNITY INVOLVEMENT IN FIGHTING WITH AIDS IN VIETNAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0332 H. Nguyen Thi Lan This low level derive from the misconception on HIV/AIDS and the severe stigma/discrimination against PLHA in Vietnam. However, we saw a positive sight when 93.3% of respondents said that they are willing to help PLWHA under physical or spiritual form. |
| WePE0333 | SOME CHARACTERISTICS OF PLWHA IN TWO PROVINCES IN VIETNAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0333 N.T. Long1, P.T. Huong2, B.H. Duc2, N.T. Mai2, S. Maryam2, D.T.T. Hoa3, N.T. Khanh3 PLWHA is still one of the priority target groups due to their behaviors of unsafe sex and sharing syringe when injecting drug; high rate of paid sex among PLWAs in contrast with low rate of consistent use of condom; considerably high rate of HIV positive status among sexual partners and wives of PLWAs who ever had test for tracing HIV. |
| WePE0334 | REDUCING STIGMA AND DISCRIMINATION AGAINST PEOPLE LIVING WITH HIV/AIDS IN EDO STATE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0334 S. Amuwa1, O. Soyombo2, T. Ofem3 Negative attitudes to PLWHAs by target groups confirms data from the same study on misconceptions about HIV/AIDS and route of transmission. These present significant challenges to propose scale up of prevention, treatment and care services to PLWHAs in the State. Young people especially need specific stigma and discrimination tailored messages to reduce stigma and discrimination against PLWHAs' in the State. |
| WePE0335 | BREASTFEEDING PRACTICES BY HIV STATUS IN ADDIS ABABA, ETHIOPIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0335 A. Abashawl1, A. Isehak Ahmed2, A. Bedri3, Y. Mengistu4, S. Omer1, S. Kumbi2, B. Gudetta3, R. Adamu1, A. Ruff1 Approximately half of HIV-infected women who had planned to breastfeed their infants were doing so at 14 weeks, compared to 97% of HIV uninfected women. However, HIV-infected women who did breastfeed their infants, were more likely to do so exclusively, perhaps because of more intensive counseling indicating the benefits of that practice. |
| WePE0336 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0336 Abstract not available |
| WePE0337 | INNOVATIVE APPROACHES TO INCREASE UPTAKE OF HIV COUNSELING AND TESTING SERVICES IN GHANA, ETHIOPIA AND THE CARIBBEAN REGION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0337 K. Curran1, Y. Abduljewad2, C. Ruparelia1, T. Kebede3, S. Wyss1, A. Kyei4, P. Lee5, J. Anderson6 Programs should use an appropriate mix of innovative approaches to increase use of CT services. Stigma must be addressed, with the ultimate goal being to create a new social norm for all adults in high-prevalence countries to know their HIV status. |
| WePE0338 | PRIOR TESTING, EXPOSURE TO FAMILY PLANNING AND ANTENATAL SERVICES, AND HIV STATUS AMONG WOMEN ATTENDING COUPLES' VCT CENTERS IN LUSAKA, ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0338 A. Kelley, Rwanda Zambia HIV Research Group Women who previously tested for HIV and whose partner previously tested were less likely to be HIV+, suggesting that prior testing and counselling for HIV, which provides risk reduction counselling and behavior change skills, is associated with decreased risk of HIV infection. The data also indicate that greater exposure to health services, such as family planning and antenatal care, may result in decreased risk of HIV infection. |
| WePE0339 | IMPACT OF VOLUNTARY COUNSELLING AND TESTING SERVICE ON REPORTED RISK BEHAVIOUR WITHIN THE INTEGRATED HIV/TB/STI PROTEST INTERVENTION IN MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0339 C. Rhehab1, C. Watts2, G. Charity1, L. Kumaranayake2, N. Hargreaves3, S. Vyas2, P. Vickerman2, K. Msowoya1, F. Salaniponi1, C. Floyd4, P. Godfrey-Faussett5 The results suggest that VCT has an important impact on reported sexual behaviour, with its impact differing by sex and HIV status. Men seem more able to change behaviour than women, with the greatest changes being among HIV negative men. The findings suggest that as well as providing an entry point for care and treatment, VCT may have an important impact on the behaviour of clients testing negative. Further research is needed to explore the sustainability of behaviour change reported. |
| WePE0340 | HIGH RATES OF DISCLOSURE TO MALE PARTNER AMONG HIV-POSITIVE AND HIV-NEGATIVE WOMEN TESTING IN ANC THROUGH PMTCT PROGRAMS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0340 C. Baek1, S. Kaai2, S. Geibel2, P. Omondi McOdida3, B. Ulo3, G. Muthumbi3, C. N'Katha4, N. Rutenberg1 Rates for both HIV testing and disclosure are high among women accessing ANC services in the study community. These results suggest that testing for HIV has become normalized behavior among pregnant women. High disclosure rates suggest that most women are willing to talk with their male partner without fear of negative outcomes. Programs should continue to support women in disclosing to their partner, including providing information to reduce risk of infection or re-infection as well as comprehensive information regarding subsequent steps necessary to reduce MTCT. |
| WePE0341 | DETERMINANTS RELATED TO THE UTILIZATION OF VOLUNTARY COUNSELLING AND HIV TESTING SERVICE IN VIETNAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0341 H.T. Nguyen1, S.U. Bhuiyan2, S. Nanthamongkolchai3 There were five determinants related to utilization of voluntary counselling and HIV testing service in Vietnam, including: Marital status; Residence; Health problems related to HIV infection; Risk behaviors of client's sex-partner and Information sources of the service. |
| WePE0342 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0342 Abstract not available |
| WePE0343 | DELIVERING VOLUNTARY HIV COUNSELLING AND TESTING IN THE MIDDLE EAST REGION - CHALLENGES AND LESSONS LEARNED FROM JORDAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0343 A. As'ad1, B. Khraisat2, S. McGill3 While wide-spread VCT should continue to be available for the general population, focused interventions to engage those most-at-risk need to be carefully explored and implemented particularly in an environment of high stigma including the availability of anonymous testing. |
| WePE0344 | MOBILE VS STATIONERY VCT SERVICES: A CASE OF INCREASED VCT UPTAKE IN WORKPLACES IN ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0344 M. Nyumbu, R. Lungu, S. Mutonyi Increase mobile VCT services in order to bring services directly to people where they congregate, workplaces and rural areas. |
| WePE0345 | THE NEED OF VOLUNTARY HIV TESTING AND COUNSELING AND RESULT DISCLOSURE AMONG MSM IN BEIJING, CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0345 H. Liu1, N. Wang1, Y. Song1, L. Zhang1, W. Yin1, Y. Shao2, Q. Zhang3, T. Wu4, H. Li1, B. Zhang4, X. Wang1 |
| WePE0346 | HIV INCIDENCE DURING A CLUSTER-RANDOMISED TRIAL OF TWO STRATEGIES FOR PROVIDING VOLUNTARY COUNSELING AND TESTING AT THE WORKPLACE, HARARE, ZIMBABWE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0346 E. Corbett1, B. Makamure2, Y.B. Cheung3, E. Dauya2, R. Matambo2, S. Munyati4, P. Mason2, A. Butterworth2 Offering a more acceptable VCT strategy of rapid HIV testing with brief pre- and post-test counseling at the workplace did not reduce HIV incidence at the workplace or individual level, despite achieving high uptake. Scale-up of VCT services needs to be accompanied by research to evaluate and maximise the potential for HIV prevention. |
| WePE0347 | DISCORDANCE, DISCLOSURE, BARRIERS AND MO TIVATIONS TO TESTING IN LUSAKA, ZAMBIA: KNOWLEDGE AND ATTITUDES ABOUT COUPLES' VCT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0347 A. Kelley, Rwanda Zambia HIV Research Group In Lusaka, while majority of those surveyed believe CVCT is good and agree to the idea of testing with their partner, the community lacks information regarding the possibility of couple HIV discordance. Integration of CVCT with existing VCT programs and antenatal programs is recommended. |
| WePE0348 | IDENTIFYING AND ADDRESSING COMMUNITY BARRIERS TO COUNSELING AND TESTING (CT) IN THE PRESENCE OF QUALITY CT SERVICES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0348 T. Mwapasa1, C. Osborne2, R. Ligowe3, J. Wachepa4 Interventions to scale up CT services must include identification of locally-specific obstacles to seeking CT and strategies to overcome them in order to increase demand. |
| WePE0349 | HIV TRANSMISSION: GUIDELINES FOR ASSESSING RISK - A RESOURCE FOR EDUCATORS, COUNSELLORS AND HEALTH CARE PROVIDERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0349 S. Theophilus, C. Checkland, K. Thomas That organizations and governments develop plain language material that is concise and easy to understand and that clearly states the conditions that need to be present in order to transmit HIV. This material should be non-judgemental and should deal with the realities that are lived by people all around the world. |
| WePE0350 | ROUTINE HIV TESTING FOR CHILDREN: CHALLENGES AND LESSONS LEARNED Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0350 C. Nawavvu1, R. Wanyenze1, A. Namale2, G. Amanyire3, J. Freers4, B. Mayanja5, C. Namukwaya6, J.F. Ssenkusu7, N. Sewankambo5, M. Kamya5 RTC for children and their caregivers should be expanded at hospitals with high prevalence of HIV among hospitalized children. Counselors should be equipped with skills to assess the readiness of children to receive counseling separately. |
| WePE0351 | ACCEPTANCE AND REASONS FOR DECLINING ROUTINELY OFFERED HIV TESTING AMONG DIVERSE SOCIO-DEMOGRAPHIC POPULATIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0351 M. Mugavero1, C. Sullivan1, A. Shaheen1, P. Leone2, B. Powers1, D. Jochem1, C. Hicks1 Overall, routinely offered HIV testing was highly accepted at 2 clinics caring for different socio-demographic populations. At a clinic serving a population of lower socio-economic status, patients were more likely to take offense at being offered testing and to decline testing due to fear of rejection if their test was positive. These findings suggest that stigma remains an important barrier among some populations. |
| WePE0352 | CHARACTERISTICS OF VOLUNTARY COUNSELING AND TESTING CLIENTS IN CONFLICT AND NON-CONFLICT AREAS IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0352 L.B. Waswa1, F. Baryarama2 VCT clients in war-torn areas of Northern Uganda are more often HIV-infected and show a higher risk profile than clients in areas not affected by war, calling for greater efforts for prevention programs, including expanded access to VCT. |
| WePE0353 | PREVALENCE AND FACTORS AFFECTING HIV SEROSTATUS DISCLOSURE AMONG PREGNANT WOMEN RECEIVING PMTCT SERVICES IN DAR ES SALAAM, TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0353 A.A. Almeida1, M. Mtebe2, J. Killewo3, P. Ndayanga4 The major barrier to disclosure is the fear of negative outcomes however; multiple partners, loss of marriage and religion (Muslim) contribute to poor disclosure of HIV serostatus. |
| WePE0354 | IMPACT OF PATIENTS' KNOWLEDGE AND ATTITUDES ABOUT TB/HIV RELATIONSHIP ON HIV TESTING AT MULAGO TB CLINIC, UGANDA: LESSONS FOR HIV COUNSELING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0354 A. Kawuma1, D. Mafigiri2, P. Nasozzi3, G. Nalugwa3, W. Bagundirire3, H. Luzze3, M. Nsereko3, A. Okwera3, H. Mayanja3, C. Wallen3, R. Mugerwa3, Uganda Case Western Reserve University Research Collaboration HIV counseling should be integrated with comprehensive health education on the TB/ HIV relationship. The community needs sensitization on the TB/HIV relationship to address stigma. |
| WePE0355 | RISK REDUCTION WITHIN DISCORDANT COUPLES DUE TO COUPLES VOLUNTARY TESTING AND COUNSELLING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0355 J. Atkinson1, E. Karita2, S. Allen2 Discordant couples previously tested using traditional practices of individual testing remain at significant risk for HIV transmission, however CVCT can drastically reduce this risk by counselling the couple together. Previous testing appears less effective at reducing risk behaviour when the female is the positive partner. The reported risk behaviour after CVCT is higher when the male partner is the negative partner. |
| WePE0356 | HIV TESTING IN ADULTS RECEIVING CARE FROM THE U.S. VETERANS HEALTH ADMINISTRATION (VHA) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0356 A. Gifford1, C. Bowman2, M. Goetz3, Y. Chen2, T. Hoang3, L. Mole4, T. Slipchenko2, S. Asch3 HIV testing is significantly underused throughout the VHA system, even in patients in care, and at highest risk. Outside-VHA testing is unlikely to explain the deficit. White, older, and rural patients are less often tested. Programs are needed to increase HIV testing in primary care. |
| WePE0357 | MOBILE VOLUNTARY COUNSELING AND TESTING (VCT) FOR HIV TO INCREASE ACCESS AMONG HIGH RISK GROUPS IN RWANDA AND INDIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0357 D. Joseph1, D.S. Waikars2, C. Buch von Schroeder3, G. Khan2 Mobile VCT is an effective way to bring services to high-risk groups in diverse settings. PSI programs have found that there is a very high demand for VCT services provided in the community. Referrals from mobile VCT may be difficult to ensure when compared to static services, however, community-based partners can be trained to link clients to services through post-test-clubs and community-based-clinics when the mobile team leaves the site. |
| WePE0358 | INCREASES IN HIV ANTIBODY TESTING IN COMMUNITY SAMPLES OF GAY MEN IN SCOTLAND, UK, 1996-2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0358 L. Williamson1, G. Hart2 HIV testing has increased among Scottish gay men and the increase among clinic users corresponds with a recent Scottish Executive policy change, recommending that all clinic users with suspected STIs are offered an HIV test. Given that early testing is essential for timely access to treatments, initiatives to widen access to testing and to target high-risk groups should continue to be encouraged. |
| WePE0359 | FACTORS INFLUENCING ACCEPTABILITY OF FAMILY-BASED HIV COUNSELING AND TESTING FOR TUBERCULOSIS EVALUATION SUBJECTS IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0359 E.D. Charlebois1, P. Srikantiah1, R. Lin1, M. Walusimbi2, A. Okwera2, C. Whalen3, H. Boom3, D. Havlir1 Integration of family-based HIV counseling and testing into TB evaluation is acceptable and willingness to refer family members for TB clinic or Home testing is high. Issues for testing family members of women including domestic violence, and disclosure should be investigated. |
| WePE0360 | ACCEPTABILITY OF HIV COUNSELING AND TESTING AMONG TUBERCULOSIS PATIENTS IN SOUTH ETHIOPIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0360 D. Dare1, A. Fita2, B. Lindtjørn3 Only a third of tuberculosis patients accepted to be HIV tested. Thus, the low acceptability of HIV counselling and testing among tuberculosis patients is a challenge to the scale-up of TB/HIV collaborative efforts. However, three-quarters of HIV positive tuberculosis patients knew about their HIV status and we encourage routinely asking patients about previous history of HIV testing. |
| WePE0361 | ENHANCING HIV COUNSELLING CAPACITY IN HEALTH INSTITUTIONS IN ZIMBABWE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0361 G. Ncube, E. Gonese, A. Mahomva, L. Madyira, F. Chikhata, O. Mugurungi Zimbabwe will continue to scale up training of the PCC in order to provide comprehensive package for HIV and AIDS prevention, care and support services and recommends the use of this non-clinical cadre in resource limited settings. |
| WePE0362 | Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0362 Abstract not available |
| WePE0363 | SUCCESSFUL INTRODUCTION OF ROUTINE, "OPT-OUT" HIV TESTING IN BOTSWANA'S PREVENTION OF MOTHER TO CHILD TRANSMISSION OF HIV (PMTCT) PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0363 T. Creek1, K. Seipone2, R. Ntumy3, M. Smith3, M. Smit3, M. Davis3, L. Mazhani2, H. Thuku4, N. Shaffer5, P.H. Kilmarx5 Routine testing was more acceptable than voluntary testing in this population, and did not deter women from seeking or continuing antenatal care. Women tested 'routinely' were more likely to receive results than women tested 'voluntarily', and equally likely to receive AZT for PMTCT. A routine testing strategy may be useful for improving access to HIV care. |
| WePE0364 | INCREASING ACCESS USING HOME-BASED CONFIDENTIAL HIV COUNSELING AND TESTING: AN INNOVATIVE COMMUNITY-BASED PROGRAM IN UGANDA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0364 J. Mabirizi1, M. Kaleeba1, E. Kisambira2, S. Kironde1, X. Nsabagasani1 If well implemented and promoted, HBCT can increase HIV counseling and testing uptake tremendously. Self selection in HCT access was however noted with more females testing than males and this may be a result of the higher likelihood of finding females at home compared to males. In HBCT as in other strategies, quality control of a subset of samples at an approved facility is still essential. |
| WePE0365 | SETTING UP VOLUNTARY COUNSELING AND TESTING SERVICES IN THE DEMOCRATIC REPUBLIC OF CONGO (DRC): THREE YEARS EXPERIENCE (OCT 02 TO SEPT 05) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0365 M. Minlangu1, M. Mayala1, H. Mukumbi2, B. Mulelebwe3, W. Mbala4, K. Makela5, R.A. Ouattara6, Y.D. Mukadi6 The focused roll-out of HCT services in 3 provinces provided valuable experience for starting-up and expanding counseling and testing on a broader scale. With community mobilization that includes interventions targeted to pregnant women, youth and men, it is possible to increase service demand. With strong partnerships with government and local NGOs and additional funding, it is possible to scale-up HCT activities at country level to better respond to the spread of the epidemic. |
| WePE0366 | HIGH UPTAKE OF HOME-BASED DELIVERY OF HIV COUNSELLING AND TESTING AMONG YOUNG PEOPLE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0366 W. Mutale1, C. Michelo1, K. Fylkesnes2 Very high uptake was achieved by delivering HIV counselling and testing at home, and the highest uptake was seen in young people with lower educational attainment. |
| WePE0367 | HIV VOLUNTARY COUNSELING AND TESTING (VCT) PREVALENCE AMONG A RANDOM SAMPLE OF YOUNG ADULTS AGED 18-32 YEARS OLD IN RURAL AREAS, NORTHERN THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0367 S. Visrutaratna1, S. Kawichai2, S. Chariyalertsak2, B. Genberg3, C. Beyrer3, C. Chariyalertsak1, M. Wichajarn2, K. Srithanaviboonchai2, D. Celentano3 HIV testing rates among the population are high, however many, particularly men and ethnic minorities, have not been tested. VCT programs designed to reach underserved groups are essential for HIV prevention and care. |
| WePE0368 | AVAILABILITY OF ANTIRETROVIRAL THERAPY (ART) AS A MOTIVATOR FOR HIV TESTING IN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0368 D. Joseph1, G. Morgan2 Without any communications efforts, hypothetical availability of ART was not a big motivator for VCT among previously uninterested, untested people in Kenya. Future research around ART availability as well as a follow-up survey for the VCT campaign wick yield additional information on the use of care messages to encourage VCT uptake. |
| WePE0369 | THE IMPACT OF PUBLIC HIV TESTING OF POLITICAL LEADERS AND PROMINENT FIGURES IN VCT SERVICE UTILIZATION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0369 T. Kebede1, T. Wuhib2, A. Asrat3, B. Gebre Mariam4, S. Ismail5, H. Negassa1 Public testing of the Mayor and Ambassador and popularization of the testing event contributed to a two fold increase in client accessing VCT services at Zewditu Hospital. Involving political leaders and prominent figures in HIV testing is an effective method of promoting VCT service acceptance and utilization. |
| WePE0370 | RAPID HIV TESTING AND PREVENTION OF MOTHER-TO-CHILD HIV TRANSMISSION IN HIGH-RISK MATERNITY HOSPITALS, ST. PETERSBURG, RUSSIA, 2004-2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0370 N. Akatova1, D. Kissin2, A. Rakhmanova3, E. Vinogradova4, E. Voronin5, D. Jamieson2, M.K. Glynn6, J. Robinson7, W. Miller8, S. Hillis2 The use of RT achieves timely detection of HIV-infected women presenting in labor with undocumented HIV status and appropriate ARV prophylaxis to these women and their infants. The success of MTCT prevention program could be improved by: strengthening community-based programs emphasizing the importance of prenatal care and early presentation for labor. |
| WePE0371 | THE SCALE-UP OF HIV COUNSELING AND TESTING IN KENYA FROM 2000 TO 2005: A REPLICABLE MODEL FOR OTHER COUNTRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0371 E. Marum1, M. Taegtmeyer2, C. Ngare3, J. Odoyo1, A. Ikahu4, K. Chebet3, K. DeCock1 Applying the lessons learned in Kenya will assist policy makers in other countries facing similar challenges of inadequate health manpower, lack of awareness about the benefits of testing, and weak systems for quality assurance. This experience can be translated to the expansion of HIV in clinical settings, with the aim of universal knowledge of serostatus, and to the scale-up of HIV prevention services and AIDS treatment. |
| WePE0372 | PRE-TEST AND POST-TEST COUNSELLING GUIDE FOR GPS WHO SEE PATIENTS FROM HIGH HIV PREVALENCE COUNTRIES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0372 C. McLean, S. Cairnduff, L. Wray, S. Williams, L. Marceau-Pitts, C. Read, B. Nepal Australia has recently had an increase in immigrants from high HIV prevalence countries (HHPCs) in sub-Saharan Africa. Australia has relatively low HIV prevalence (69 per 100,000), however recent immigrants are over represented. They generally have poor access to health services and tend to be late presenters for HIV testing. |
| WePE0373 | BATHHOUSE-BASED VOLUNTARY COUNSELING AND TESTING IS FEASIBLE AND SHOWS PRELIMINARY EVIDENCE OF EFFECTIVENESS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0373 D.M. Huebner, D. Binson, W. Woods, S. Dillworth, T. Neilands, O. Grinstead Bathhouse-based VCT appears to be a feasible approach for reaching significant numbers of men at risk for HIV and shows preliminary evidence of effectiveness in changing HIV-related risk and precautionary behaviors. |
| WePE0374 | USE OF RAPID HIV TESTING IN HOSPITALS, COMMUNITY CLINICS, AND COMMUNITY-BASED ORGANIZATIONS IN THE UNITED STATES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0374 S. Asch1, L. Bogart2, J. Lange3, D. Howerton3, K. Becker4, C.M. Setodji2 In a developed country, rapid HIV testing in the private sector is primarily used after occupational exposure in hospitals and infrequently for any reason in community settings. Policies should be developed to encourage greater breadth of diffusion of rapid testing, especially in settings where rapid dissemination of results will improve care, such as in emergency rooms, labor and delivery, and mobile testing sites. |
| WePE0375 | WHO RETURNS FOR HIV TEST RESULTS? DATA FROM THE 2005 ASSESSMENT AMONG POPULATIONS OF MEN WHO HAVE SEX WITH MEN IN THAILAND Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0375 S. Naorat1, A. Varangrat1, P. Utokasenee2, S. Visarutratana3, P. Phanuphak4, K. Kanggarnrua5, J.W. Tappero6, J. McNicholl7, F. van Griensven7, the Thailand MSM Study Group The great majority of HIV-positive study participants failed to return for HIV test results. HIV rapid testing and factors identified in our study may help to increase the number of study participants returning for HIV test results. |
| WePE0376 | MEASURING THE EFFECTIVENESS OF DIAGNOSTIC TESTING AND COUNSELING TRAINING IN SELECTED DISTRICTS IN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0376 S. Abdallah1, N. Koskei1, J.M. Machoki2, I. Tanui3, P. Lynam1 JHPIEGO's training package for DTC is practical for scaling-up DTC and should be adopted by NASCOP and other partners. DTC partners should develop a tool to assess health facility readiness to target training at sites most likely to implement DTC successfully. |
| WePE0377 | PERCEPTIONS ABOUT HOME-BASED HIV TESTING AMONG RESIDENTS OF SELEBI-PHIKWE AND BOBIRWA DISTRICTS, BOTSWANA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0377 A.W. Taylor1, K.A. Kroeger2, V. Beyleveld3, C. Wilson3, D. Fleming4, H.M. Marlow2, T.H. Roels4, D.K. Smith5, P.H. Kilmarx6 Focus-group participants in these high-HIV-prevalence districts expressed support for a home-based HIV counseling and testing program and also stressed the need to address community concerns before implementation. |
| WePE0378 | LESS TALK AND MORE TESTING: HOW NYC HAS INCREASED HIV TESTING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0378 M. Henn, E. Begier, K.A. Sepkowitz, S. Kellerman Concurrent HIV and AIDS diagnosis represents 28% of all newly diagnosed cases in New York City (NYC) and is associated with poorer health outcomes. We describe NYC Department of Health and Mental Hygiene's (DOHMH) efforts to test more New Yorkers. |
| WePE0379 | UPTAKE OF POST PREGNANCY HIV-1 TESTING IN MCH CLINIC Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0379 J. Kinuthia1, M. Chung2, F. John1, B. Richardson2, C. Farquhar2, G. John-Stewart2, J. Kiarie1 Majority of women accepted post pregnancy HIV-1 testing in MCH clinics and many HIV-1 positive women who did not know their status were identified. This is a useful strategy to reach women who acquire HIV-1 infection after antenatal HIV-1 testing and those who were not tested antenatally. |
| WePE0380 | GENDER DIFFERENTIALS IN ALCOHOL USE AND HIV TESTING AMONG HEALTH WORKERS IN KENYA: EVIDENCE FROM A NATIONAL SURVEY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0380 K. Kiragu1, I. Tanui2, G. Baltazar2, J. Wanyungu2, S. Kaai3 The data suggest a core group of health workers who may be abusing alcohol. Given their role in patient management, their further study is essential to document the extent of alcohol abuse in their personal and professional lives. The study also found that although males are more likely to abuse alcohol, females are more likely to have been tested for HIV. This suggests that males may need more attention than females to address problem drinking and to understand the relationship of alcohol to HIV risk behaviors. |
| WePE0381 | TALKING TO NEWLY DIAGNOSED NEW YORKERS AND TESTING THEIR PARTNERS: PUBLIC HEALTH DOES IT BETTER Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0381 M. Malave1, D. Shah1, E.M. Begier1, S. Rubin2, S.E. Kellerman1, J.A. Sackoff1 DIS PN interviews resulted in identification of substantially more new HIV diagnoses than did interviews conducted by other NYC providers. If DIS interviews were successfully implemented for all NYC cases, partner notification might identify up to 340 newly diagnosed persons per year. Based on these findings, NYC is planning to expand PE/PN by Health Department personnel who have the motivation, time and resources to elicit more partners. |
| WePE0382 | CHARACTERISTICS, BEHAVIOR CHANGE, AND HIV SEROINCIDENCE AMONG CLIENTS PRESENTING FOR REPEAT VOLUNTARY COUNSELING AND TESTING IN MOSHI, TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0382 A. Tribble1, J. Crump1, A. Mgonja2, D. Itemba2, K. Landman1, E. Ndosi3, J. Shao4, J. Bartlett1, N. Thielman1 Clients presenting for repeat VCT reported positive behavior changes and improved knowledge of the sexual practices and HIV serostatus of their partner(s). Assessing changes in behavior and HIV knowledge through VCT should be a focus of HIV prevention efforts. |
| WePE0383 | TRAINING OF TRAINERS IN STRESS MANAGEMENT: A STRATEGY TO OVERCOME HUMAN RESOURCE PROBLEM IN VCT IN NAMIBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0383 O. Oke Namibia, with a population of over 1.8 million and HIV prevalence of 19.7% (2004 Sentinel Surveillance) is one of the most affected countries in Sub-Saharan Africa by the HIV/AIDS epidemic. Recognizing the magnitude of the epidemic, Namibia launched a rapid response to scale up its HIV/AIDS prevention and treatment programme in 2003. One key component of the response was a rapid expansion of Voluntary Counseling and Testing (VCT) in all regions to support its anti-retroviral Therapy (ART) and PMTCT services. Over 200 VCT sites were established to provide voulntary counseling and testing. One key challenge faced by the scale up was limited service providers especially counselors. Trained counselors had started experiencing stress and burnout. This abstract presents one of the strategies adopted by Namibia to overcome human resource problem in its testing and counseling services. |
| WePE0384 | ENHANCING VOLUNTARY HIV TESTING AMONG UNIVERSITY STUDENTS - THE KNOW YOUR STATUS (KYS) PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0384 S. Rutstein, M. Mugavero, C. Sullivan, L. Bickers Bock, C. Hicks Free, rapid HIV testing has been enthusiastically received by students, perhaps reflecting pent-up demand for readily accessible testing services. Persons tested are a representative sample of the student body. This innovative approach has enhanced awareness and availability of HIV testing among sexually active college students and may facilitate better reproductive health on campus. |
| WePE0385 | SKILL-BUILDING WORKSHOPS FOR PROVIDERS IN HIV RISK ASSESSMENT PREVENTION COUNSELING: CULTURAL CONSIDERATIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0385 S. Lemme We recommend the use of training workshops which include opportunities for providers to practice skills appropriate to the culture of their patient population. We also encourage discussion of the approaches which are successful within specific patient and provider cultures. |
| WePE0386 | EFFECTIVE HIV PARTNER COUNSELING AND REFERRAL SERVICES (PCRS): SAN FRANCISCO, 2004 - 2005 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0386 C. Kent, G. Nieri, K. Ahrens, J. Klausner The proportion of new infections detected among identified partners in San Francisco was similar to the national average, and similar to the national number of cases interviewed to detect one new infection. With extensive staff training PCRS can be effective among a primarily MSM population. PCRS is an important tool in identifying new HIV infections and enabling partners to receive early care and prevention counseling. |
| WePE0387 | PREDICTING HIV TESTING IN A SAMPLE OF HIGH-RISK SOUTH AFRICAN WOMEN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0387 W. Luseno, W. Wechsberg, K. Riehman As the capacity to provide care and treatment to those who are HIV positive increases in South Africa, it is necessary to raise awareness of the benefits of individuals knowing their HIV status, especially those who are considered to be high-risk. |
| WePE0388 | DETERMINANTS OF VCT UPTAKE IN 5-YEAR HEINEKEN HAART PROGRAM IN AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0388 T.F. Rinke de Wit1, S. Vander Borght2, M. Schim-vander Loeff3, P. Clevenbergh1, K. van Cranenburgh2, H. Rijckborst2 VCT uptake is a dynamic process with various determinants motivating different people to opt for an HIV test. Any one intervention only results in a transient peak in VCT uptake. Therefore, constant stimulation of target populations using different motivating strategies will result in the highest cumulative VCT uptake. Alternative interventions are required to reach spouses and children. Workplace programs should recognize the consequences of preferential uptake of beneficiaries with full blown AIDS during the early phases of roll-out. |
| WePE0389 | ENSURING HIGH RATE OF RETURN FOR CONFIRMATORY HIV RESULTS AMONG BLACK AND LATINO MEN WHO HAVE SEX WITH MEN (MSM) THROUGH COUNSELOR/CLIENT RELATIONSHIP BUILDING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0389 A. De Los Reyes1, P. Kummel2 Organizations invested in increasing their rate of return for confirmatory HIV-positive results among Black and Latino MSM's may find that incorporating comprehensive, population specific training curricula and discouraging counselors from a "one size fits all" counseling model, may yield improved results. |
| WePE0390 | A COMPREHENSIVE APPROACH TO A PROCESS EVALUATION OF COUPLES' VOLUNTARY COUNSELING AND TESTING (CVCT) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0390 E. Karita1, H.D. Shah2, N. Leblanc2, L. Beaty2, Rwanda Zambia HIV Research Group (RZHRG) CVCT is an effective intervention that should be widely replicated, and this study provides a useful evaluation model specific to couples' VCT. Further research should focus on developing additional and more time-efficient tools to assess and document the protocols, quality, and impact of CVCT services. |
| WePE0391 | UPTAKE OF VOLUNTARY COUNSELLING AND TESTING IN THE CONTEXT OF ANTIRETROVIRAL THERAPY IN KISESA, TANZANIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0391 A. Wringe1, M. Urassa2, J. Busza1, R. Isingo2, J. Mshana2, J. Wamoi2, J. Changalucha2, B. Zaba1, R. Manyala2, G. Maiseli2, S. Kalluvya3 Socio-demographic factors influenced VCT uptake among males and females in different ways. Furthermore, HIV positive males tended to self-select for VCT, while a similar pattern was not seen among females. This may lead to a disproportionate number of women who are in need of ART, failing to access HIV testing and appropriate onward referral services. |
| WePE0392 | HIV RAPID TESTING: AN APPROACH TO STEMMING HIV/AIDS IN THE AFRICAN AMERICAN COMMUNITIES OF ALAMEDA COUNTY WITH RESPECT TO THE LOCAL STATE OF EMERGENCY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0392 S. Richey, G. Lockett, S. Mathai HIV rapid testing and counseling is a powerful prevention and education tool for high-risk, hard to reach and/or hidden populations. It allows individuals to quickly determine their HIV status. In addition, HIV positive individuals can be linked to vital services, including care and treatment, and socials service programs. |
| WePE0393 | VOLUNTARY COUNSELING AND TESTING (VCT) CAN BE IMPLEMENTED IN BATHHOUSES WITHOUT AFFECTING PATRONAGE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0393 D. Huebner, D. Binson, L. Pollack, W. Woods Prevention providers should collaborate with bathhouses to offer VCT to patrons. With respect to client turnover and room rentals, VCT is unlikely to adversely impact bathhouse business. |
| WePE0394 | VOLUNTARY COUNSELLING AND TESTING UP-TAKE INCREASED OVER FOUR-FOLD AFTER STARTING ART IN A TANZANIAN DISTRICT HOSPITAL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0394 M. Stoeckle1, E. Ikongoni2, H. Masanja3, C.F.R. Hatz4, M. Tanner4, M. Battegay5 The introduction of ART at SFFDH led to an over 4-fold increase in VCT-up take. Positive HIV-tests increased after the introduction of ART. The gender-ratio of VCT clients did not change due to the introduction of ART. The increase of individuals attending VCT and the increased number of positive tests indicates the importance of treatment programs for VCT and prevention. Knowledge of the HIV-status as well as information provided to clients how to prevent infection of partners or how to stay HIV-negative respectively are important preventive tools which can be strengthen by ART introduction. |
| WePE0395 | A SYSTEMATIC REVIEW OF THE IMPACT OF VOLUNTARY HIV COUNSELING AND TESTING (VCT) ON RISK BEHAVIORS IN DEVELOPING COUNTRIES (1990-2005) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0395 J.A. Denison1, K.R. O'Reilly2, G.P. Schmid2, D. Strouse3, C.E. Kennedy1, M.D. Sweat1 Even with the inclusion of new studies since our last synthesis there remains mixed evidence for VCT as an effective behavior change strategy in developing countries, with weak study designs and poor replication among studies limiting the strength of evidence. VCT continues to show the most behavior change between couples tested together, and among HIV-infected individuals, especially with non-primary partners. |
| WePE0396 | TRENDS IN HIV PREVALENCE IN ZANZIBAR (TANZANIA): IMPACT OF AN HIV PREVENTION PROGRAMME Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0396 P. Rivas1, F. Valdés2, M. Roura3, A.O. Hassan3, R.I. Hassan3, C. Coll3, T. García3, R. Fernández3, A. Munne3, B. Ramírez3, C. Saura3, R. Garitaonandia3, J.J. del Pozo3, O. Sued3, K.A. Nassor3, M.J.U. Dahoma4, I. Casas3 The impact of the epidemic is higher in females but their demand of VCT is lower than males. However, the number of woman that seeks VCT service is growing while their age and their prevalence of HIV seems to be diminishing. More efforts are needed to maintain this tendency. |
| WePE0397 | ATTENDANCE AND ATTITUDES TOWARD VOLUNTARY COUNSELING AND TESTING (VCT) IN RURAL MALAWI Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0397 S. Yeatman1, P. Fleming2 This research suggests that valuable data can be collected at local VCT centers and that more focus on primary data collection and surveillance is warranted in existing centers. |
| WePE0398 | AFRICAN MIGRANTS IN ANONYMOUS HIV TESTING, FRANCE 2004 Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0398 S. Le Vu, C. Semaille Since some barriers are lowered, anonymous testing should be an appropriate frame for migrants to seek for an HIV test. Yet, it seems that there is still an insufficient uptake of anonymous VCT from this community. In another study, the main reason for migrants for the uptake of HIV testing is knowing that the treatment exists and is accessible in case of positivity. Prevention intervention should enhance the conscience of being at risk while in couple and remind that every HIV-positive person in France can access freely to care and treatment. |
| WePE0399 | INTRODUCTION OF RAPID TEST TO VCT AND CONTINUOUS EVALUATION SYSTEMS IN JAPAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0399 K. Nakase1, T. Shima2, M. Imai3, T. Tachibana4 Same-day VCT has been adopted by public VCT in Japan and the monitoring system is better than the other VCT sites, but is still not adequate. Effective monitoring is recommended in order to improve VCT in Japan. |
| WePE0400 | IMPACT OF IMPLEMENTING ROUTINE ANTENATAL HIV TESTING ON PMTCT SERVICE STATISTICS IN A RURAL DISTRICT IN ZIMBABWE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0400 T. Mandendera1, B. Engelsmann1, L. Mugore1, F. Perez2 This study demonstrates that routine testing can be successfully introduced on district level, resulting in a general improvement of quantitative ANC service statistics. Further qualitative research into the understanding and effect of this new approach on clients will complement these results. |
| WePE0401 | THE ROLE OF VOLUNTARY COUNSELLING AND TESTING IN PREVENTING HIV INFECTION AND TREATING AIDS PATIENTS: THEORETICAL INSIGHTS FROM MATHEMATICAL MODELLING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0401 T.B. Hallett1, S. Dube1, A. Mahomva2, G. Ncube2, O. Mugurungi2, S. Gregson1, G.P. Garnett1 Behaviour change promoted through VCT can have a substantial impact on the heterosexual spread of HIV and the demand for anti-retroviral therapy. VCT services must be focussed on testing as many people as possible, promoting initial testing and targeting the young and those most at risk where resources are most limited. |
| WePE0402 | EFFECTIVE HIV CASE IDENTIFICATION THROUGH ROUTINE HIV TESTING IN CLINICAL SETTINGS IN MICHIGAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0402 L. Randall1, W. Berk2 Compared with targeted testing efforts, routine testing in clinical settings had a higher prevalence rate and therefore is a valuable public health strategy. Implementation of routine testing may be most cost efficient in areas of relatively high HIV prevalence or that serve patients at relatively high risk. |
| WePE0403 | INTERACTIVE VIDEO (IAV) AS AN UNOBTRUSIVE MEASURE OF HIGH RISK TAKING AMONG MSM POPULATIONS UNCOMFORTABLE WITH DIRECT DISCUSSIONS OF THEIR SEXUAL BEHAVIOR Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0403 C. Godoy1, P.R. Appleby2, L.C. Miller1, S.J. Read2 This study demonstrates that MSM engage in risk taking practices in an interactive virtual environment that are consistent with their recent past behavior. Use of IAV may be a good strategy to use in lieu of an intake interview about sexual risk to guide an interventionist's discussion of HIV risk behavior with a client. |
| WePE0404 | AN INTEGRATED HIV OUTREACH & SERVICE INTERVENTION MODEL FOR YOUNG LATINO MSMS: RESULTS FROM A PILOT PROJECT Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0404 J.T. Erausquin1, N. Duan2, O. Grusky3, E. Rudy4, A.-N. Swanson5, T. Horton6, D. Kerrone6, P. Amezola de Herrera6 The results of this pilot study demonstrate the effectiveness of an integrated targeted outreach and service intervention in an urban setting to reach young Latino MSMs at risk for HIV infection. |
| WePE0405 | FEASIBILITY OF ROUTINELY OFFERED HIV TESTING AMONG DIVERSE SOCIO-DEMOGRAPHIC CLINIC POPULATIONS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0405 M. Mugavero1, C. Sullivan1, A. Shaheen1, P. Leone2, B. Powers1, D. Jochem1, C. Hicks3 A routinely offered, pamphlet-based approach to HIV testing using rapid tests was successfully implemented in 2 busy primary care clinics caring for markedly different socio-demographic patient populations. This approach was well accepted by patients, providers, and clinic staff and may facilitate more widespread HIV testing in diverse primary care settings. |
| WePE0406 | HELPING THE HELPERS - NETWORK OF VOLUNTARY CONFIDENTIAL COUNSELING AND TESTING (VCCT) COUNSELORS PROVIDES AN EFFECTIVE VENUE FOR PEER SUPPORT AND CAPACITY STRENGTHENING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0406 P. Sok, P. Prom, C. Chea VCCT counselors in Cambodia are working in an ever-changing environment, often isolated from peer support and facing new and challenging situations. The expansion of VCCT services in Cambodia has highlighted the importance of providing VCCT counselors with continuing learning opportunities and follow-up support to strengthen and update their knowledge and counseling skills. |
| WePE0407 | INTEGRATING MULTIPLE MODELS OF COUNSELING, TESTING AND REFERRAL (CTR) INTO AN ALREADY ESTABLISHED HIV TESTING PROGRAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0407 A. De Los Reyes Sites offering HIV CTR services should consider incorporating multiple models of CTR that address the specific needs of the client, testing locations and effectively addresses required elements of client/counselor interactions. |
| WePE0408 | ACCEPTABILITY OF VOLONTARY COUNSELING AND TESTING (VCT) OF HIV AMONG FEMALE SEX WORKERS IN CONAKRY, GUINEA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0408 J. Aho1, S. Diakité2, V.-K. Nguyen1, S. Rashed1 These data indicate that VCT acceptability is high among female sex workers in Conakry. This seems to be due to the increasing consciousness about HIV/AIDS but also because of social pressure. Counseling sex workers on consequences of public disclosure of their status and pub managers on VCT's confidentiality should be included in the setting of a VCT program for sex workers. |
| WePE0409 | EFFECT OF HEALTH EDUCATION ON THE KNOWLEDGE AND ACCEPTABILITY OF VCT FOR HIV AMONGST ANTENATAL PATIENTS IN KEBBI, NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0409 J.A. Oyetunji Adequate health information about HIV/PMTCT is an effective way of improving uptake of VCT for HIV among pregnant women receiving antenatal care. |
| WePE0410 | PROVIDING RAPID HIV COUNSELING, TESTING AND REFERRAL (CTR) SERVICES AT OFFSITE LOCATIONS - CTR MOBILITY Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0410 A. De Los Reyes Organizations providing rapid HIV CTR services should explore the possibility of CTR mobility in order to meet the communities they serve where they socialize and where there is community support and encouragement of the HIV CTR process. |
| WePE0411 | PILOT MODEL OF VIETNAM MINISTRY OF HEALTH (MOH) VOLUNTARY HIV COUNSELING AND TESTING SERVICE (VCT) IN HAI PHONG CITY, VIETNAM Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0411 T. Nguyen Trong, C. Luu Minh, M. Luu Nhat VCT service should be maintained, enhanced, and evaluated to develop a standard VCT model to expand to other localities with large size of high-risk populations. Referred services should also be strengthened with focusing on HIV care. |
| WePE0412 | COUNSELING AND TESTING (CT) IN CLINICAL SETTINGS: THE TRAINING NEEDS OF KENYAN HEALTH WORKERS Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0412 I. Tanui1, K. Kiragu2, G. Baltazar1, J. Wanyungu1, S. Kaai3 Many health workers are providing CT without the benefit of relevant guidelines, and over a quarter have not even been trained in HIV testing. There is need to equip these professionals with appropriate skills, and to avail them the relevant guidelines to facilitate their tasks. |
| WePE0413 | RECRUITMENT OF DISCORDANT COUPLES FOR A PHASE III CLINICAL TRIAL IN THE COPPERBELT, ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0413 B. Lambdin, H. Shah The recruitment of HIV discordant couples for a clinical trial poses many challenges. The INA model is the most successful means of recruiting couples to be tested in the Copperbelt of Zambia where there is little infrastructure for CVCT clinics. However, this means of recruitment is expensive and requires a commitment of financial resources to be effective. |
| WePE0414 | STD/HIV COUNSELING IN WAITING ROOM AS A FEASIBLE COMPREHENSIVE APPROACH IN PRIMARY CARE SERVICES Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0414 D. Nagae, A. Badran, N. Formícola, F. Kawasaki, W. Miyamoto, R. Olivato, M. Simonsen, L. Takahashi, R. Veloso, E. Tambellini, C. Luppi This pilot-test has shown that low costs and easy interventions in waiting rooms could provide information and counseling for men and women promoting equity in reach with no difference between genders among the acceptability, evidencing a possibility of lowering their STD/HIV vulnerability. |
| WePE0415 | PREVENTION OF PARENT TO CHILD TRANSMISSION OF HIV PROGRAM - DOES SEXUAL PARTNER COUNSELING MAKE A DIFFERENCE? Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0415 U. Tendolkar1, N. Borges2, W. Bhatki1, R. Bhosale1, J. Bhavsar3 Intensive counseling has resulted in increased sexual partner participation of HIV positive women and an increase in capture of HIV positive men thereby indirectly curtailing the overall spread of HIV infection. |
| WePE0416 | IMPLEMENTATION AND EFFECTIVENESS OF RAPID HIV TESTING AT PUBLICLY FUNDED VOLUNTARY HIV COUNSELING AND TESTING (VCT) SITES IN JAPAN Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0416 T. Shima1, M. Isshiki2, M. Tsukada2, S. Shiomi2, R. Yasunari3, H. Watanabe3, H. Ueyama3, K. Sudo1, M. Kondo1, K. Nakase4, M. Imai1, The Study Group on the Development of HIV Testing Systems The rapid HIV test proved to be successful in increasing the number of HIV test applicants. Due to the increase of implementation of the rapid HIV test at VCT sites, the number of HIV test applicants has also increased. |
| WePE0417 | YOUTH-FRIENDLY VOLUNTARY COUNSELING AND TESTING IN MOZAMBIQUE: A NEW PARADIGM FOR YOUTH HIV PREVENTION AND CARE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0417 I. Zilhao1, J. Cardoso2, C. Chibindji3, L. Vander Veken1, N. Osman4, D. Aurora4, R. Benevides2, S. Sheldon2 |
| WePE0418 | USING CLINICAL RESEARCH AS AN OPPORTUNITY TO PROMOTE COUPLE HIV COUNSELLING AND TESTING (CHCT) Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0418 A.M. Owor1, P. Ndase1, T. Sekoto1, M. Nthsimane1, M. Malamba1, A. Mujugira2, J. Makhema3, I. Thior3, C. Celum4, M. Essex5, The Netefatso HSV-2/HIV Transmission Study A clinical research team, in developing recruitment strategies, should be tasked with establishing a good referral system for potential participants and also promoting HIV prevention interventions and community education. |
| WePE0419 | TESTING CORNERS': A KEY STRATEGY IN SUPPLYING SAME DAY HIV RESULTS IN ZAMBIA PREVENTION, CARE AND TREATMENT PARTNERSHIP (ZPCT) SUPPORTED PROVINCES OF ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0419 K. Torpey1, S. McGill2, P. Kasonde1, M. Tembo1, N. Sialwiindi1, M. Wigley2 Testing corners should be integrated into all CT/PMTCT rooms and all counsellors trained to perform rapid HIV testing to ensure same day results. |
| WePE0420 | THE SUCCESS OF USING PEOPLE WITH NO MEDICAL BACKGROUND IN OFFERING HIV COUNSELLING AND TESTING - A MALAWI NGO EXPERIENCE Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0420 G. Kamanga1, E. Gumbo2 In poor resource countries like Malawi the use of people with no medical background to offer Voluntary Counselling and Testing after training them is feasible. |
| WePE0421 | A DESCRIPTIVE STUDY OF VCT IMPLEMENTATION IN THE ACCRA METROPOLITAN DISTRICT, GHANA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0421 V. Wong Findings gave an initial picture of VCT implementation in the district. Regarding compliance to guideline indicators, VCT services showed a range of differences with no detectable differences among subgroups. Facilities from all sectors and types complied with many minimum standards. Current standards are theoretically attainable. However, many VCT facilities in each sector didn't meet the minimum standards. |
| WePE0422 | BEHAVIORAL CHARACTERISTICS OF INDIVIDUALS ATTENDING TWO NATIONAL VOLUNTARY COUNSELING & TESTING (VCT) MODEL SITES IN ADDIS ABABA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0422 T. Kebede1, J. Ahmed2, T. Wuhib3, A. Asrat4, S. Ismail2, G. Assefa5, H. Negassa6, B. Gebre Mariam7 High correlation observed between HIV positivity and perceived high risk, no condom use in last sex, being young (20-29 years), and being never married. The finding will be utilized to improve VCT service delivery planning, monitoring and evaluation and guide client and community education. |
| WePE0423 | OUTREACH VCT: A CRITICAL TOOL FOR MEETING NEEDS IN RESOURCE CONSTRAINED COMMUNITIES IN NIGERIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0423 L. Akinkugbe1, I. Akin-Jimoh2, F. Onifade2, J. Sande2 Mobile VCT service is an effective tool for reaching out in resource-constrained communities as we have in Nigeria. In addition, this could be used with extensive follow-up particularly for people who test positive and need on-going counseling. However it is essential to build capacities of community members to ensure that support structures are in place. |
| WePE0424 | EXPERIENCE DELIVERING COMMUNITY-BASED HIV VOLUNTARY COUNSELING AND RAPID TESTING (CBVCT) IN SEX WORK VENUES IN LIMA PERÚ Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0424 M.L. Jiménez1, A. Ghee2, S. Sanchez1, S. Sanchez1, P. Campos3, F. Spielberg4 CBVCT shows promise in improving access of at-risk individuals to high quality and acceptable screening services. We recommend that this refinement to delivery of a potentially highly effective preventive intervention be evaluated and scaled up in Perú and other settings. |
| WePE0425 | OVERCOMING CULTURAL CONSTRAINTS TO ESTABLISH EGYPT'S PILOT VCT PROGRAM AND SCALING-UP TO THE MIDDLE EAST REGION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0425 C. Soliman1, D. Khaled1, S. McGill2, N. El Sayed3 Given the widespread acceptance of VCT in Egypt following the adaptation of world-wide practices to local contexts, replication and scaling-up of these activities throughout the region is essential in providing vastly needed data on the status of the epidemic and in enhancing AIDS education and prevention. |
| WePE0426 | MOBILE/COMMUNITY OUTREACH VOLUNTARY COUNSELLING AND TESTING: EXPERIENCE OF A MOROCCAN NGO Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0426 M. Karkouri, D. Kebir, T. Laalam, M. Sodqi, H. Himmich The MOVCT program knows an impressive success. A third van is considered. However, counsellors can experience dramatic stress as a result of full-time counselling. Regular support should be provided to counsellors in order to avoid their whitdrawal. In other part, linkage with medico-social support services should be ensured to help prevent burnout of clients tested positive. |
| WePE0427 | HIV COUNSELING AND TESTING (VCT) FOR PRESCHOOL AND SCHOOL AGED CHILDREN: EXPERIENCE AT HOSPITAL BASED PEDIATRIC VCT SITE, ETHIOPIA, EAST AFRICA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0427 D. Wondwossen In Ethiopia there is an absence of child HIV testing sites and a lack of trained child VCT counselors. There is a need to train pediatric VCT workers and integrate child VCT services into existing VCT sites. Detailed policy guidelines are needed on issues such as age of consent and disclosure of results to children. |
| WePE0428 | SCALING UP VOLUNTARY HIV COUNSELLING AND TESTING SERVICES IN CHINA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0428 X. Wang, H. Liu, L. Zhang, Y. Song, N. Wei, M. Xiao Although 2,117 VCT centers have been established in China, it is a challenge that VCT services still can not access to all of people who are at high risk effectively. Next step will focus on improving people's health seeking behaviour for VCT services through health promotion and outreach work. |
| WePE0429 | COUNSELLLING HIV POSITIVE MOTHERS ON INFANT FEEDING: EXPLORATORY STUDY IN SÃO PAULLO, BRAZIL Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0429 M.F. Rea1, J.C. Martines2 Although health workers have good communication skills, the information provided to HIV+ mothers is insufficient. Providing infant formula and recommending against breastfeeding may not be enough to achieve safer infant feeding practices and may jeopardize well designed HIV/Aids policies. |
| WePE0430 | WHO GETS TESTED FOR HIV IN BOTSWANA?: A COMPARISON OF NATIONAL PROGRAMME DATA (VOLUNTARY COUNSELING AND TESTING AND ROUTINE HIV TESTING) AND POPULATION-BASED HIV TESTING SURVEY DATA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0430 M. Nkete1, R. Moatshe2 IEC for VCT services intensified, particularly targeting persons who are most vulnerable according to the current HIV statistics; as well as those individuals who are not likely to test. |
| WePE0431 | OBSERVED TRENDS OF COUPLES ATTENDING VCT SERVICES IN KENYA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0431 R. Mulwa1, P. Angala1, A. Parkison2 Data revealed that couples do not perceive to be vulnerable to be infected by their partners. Further research need to be done to try to understand and give explanations to these observed trends and behaviors. Empowerment of those with low education to know of their vulnerability towards HIV/AIDS among discordant couples is important. |
| WePE0432 | ESTABLISHMENT OF VOLUNTARY COUNSELING AND TESTING SYSTEM IN ARMENIA AND ITS ROLE IN HIV DIAGNOSIS AND PREVENTION Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0432 S. Grigoryan1, A. Hakobyan2, A. Papoyan3 It is recommended to increase the accessibility of VCT sites to all groups of population, expanding the geographical coverage to ensure the Universal Access to VCT and PMTCT, and VCT services further integration into the Health Care System. |
| WePE0433 | SUCCESSFUL SCALE-UP OF HIV COUNSELING AND TESTING USING ACTS FOR RAPID COUNSELING Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0433 D. Futterman1, P. Meissner2, S. Stafford1, M. Lyle1, R. Beil2 Rapid HIV counseling (ACTS) is feasible in health care settings, allowing for an efficient scale-up of HIV testing. Sustained attention to logistical and training issues is necessary to obtain significant changes in testing numbers. While evolution to opt-out HIV testing may occur within several years, ACTS offers an interim, scalable approach to increase the numbers of people who learn their HIV status, both in the US and internationally. |
| WePE0434 | MOBILE DOOR-TO-DOOR HOME VOLUNTARY COUNSELING AND HIV TESTING ANOTHER APPROACH Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0434 S. Kateregga1, E. Murana2, J.A. Muyita3 This approach so far has been successful it can even be practiced all the world and it helps to dispel allegations of HIV high prevalence rates among the population as opposed to facility based VCT which in 2004 reported as high as 24% among the overall clients served. |
| WePE0435 | PREDICTORS OF DECISION TO TEST FOR HIV AT THREE COUPLES' VCT CENTERS IN LUSAKA, ZAMBIA Int Conf AIDS. 2006 Aug 13-18;16:Abstract No. WePE0435 S.T. Roberts1, Rwanda Zambia HIV Research Group2 The results indicate that promotional activities, and especially the INA program, should focus on encouraging couples not only to attend VCT but also to test once they are there. Promotions should also focus on younger women, who may feel more afraid of the consequences of a positive HIV test result. Further research should investigate why couples are more likely to test at some VCT centers than at others. Community as well as center characteristics are likely to play a role. |
| WePE0436 | ENHANCING VCT FOR |