AEGiS-15IAC: Clinical spectrum of HIV/AIDS presenting to Gauhati Medical College, Assam- an ongoing study since January 2003.

15th International AIDS Conference

Bangkok, Thailand - July 11-16, 2004

Clinical spectrum of HIV/AIDS presenting to Gauhati Medical College, Assam- an ongoing study since January 2003.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. C10407)

Boruah PK, Adhikari AK
Gauhati Medical College and Hospital, Gauhati University, Guwahati, India

BACKGROUND: Assam, a low prevalence state of HIV/AIDS, in India, is experiencing an upsurge. Guwahati Medical College is the premier institute of Assam and the referral institute of the North -Eastern states of India. This is the first study of this kind in Assam. OBJECTIVE: 1. To study the clinical spectrum of cases. 2. To determine the epidemiologic spectrum. 3. To monitor response to HAART. Methodology: Inclusion Criteria: o All patients of all ages and sexes & seropositive for HIV I/II indicated by ELISA ( using 3 different antigens) Western Blot Investigations included routine blood/urine/stool ; CD4 count at presentation & 3 months after HAART & other relevant investigations including radiological imaging.

RESULTS: 72cases were found to be seropositive till the month of December of which majority were males (M: F:: 10:3). Most common age group was 30-39 yrs (50.77%);. Occupation: Armed forces/CRPF(42%), Housewife(19%), Truck driver(13%), Businessmen(12%), Professional Sex Worker(1 %), Others(13%). Most common mode of acquisition was Heterosexual(81.54%)Presenting features in order of frequency were Wt loss(32.31%), Fever(30.77%%), Cough ( 18.46%), Diarrhoea(15.38%), Respiratory Distress( 7.69%), Skin- manifestation(10.77%), Swelling/cervical adenopathy(4.61%), Oral ulcers(3.08%), Altered sensorium( 3.08%).18.46% were asymptomatic. Majority of patients had Generalized lymphadenopathy(27.69%), evidence of wasting (27.69%)and anemia( 26.15%). Opportunistic infections were common of which Candidaisis was most common(30.77%) folowed by tuberculosis. Most of the cases with opportunistic infection had CD4 count of<200cells/microL.3 cases had Hepatitis C co-infection while 2 case had Hepatitis B. Presently 27 cases are receiving HAART. Mortality was 7.69%.

CONCLUSION: 1) Candidiasis is the most common opportunistic infection followed by tuberculosis 2) HAART retards progression of disease.

Keywords: AEGIS, Acquired Immunodeficiency Syndrome, HIV Seropositivity, Prevalence, CD4 Lymphocyte Count, AIDS-Related Opportunistic Infections, Tuberculosis, Antiretroviral Therapy, Highly Active, Schools, Weight Loss, Heterosexuality, Infection, India, Humans, Male

040711
C10407