AEGiS-15IAC: Prevalence of oral Candida spp. in Cambodian HIV-positive and HIV-negative individuals.

15th International AIDS Conference

Bangkok, Thailand - July 11-16, 2004

Prevalence of oral Candida spp. in Cambodian HIV-positive and HIV-negative individuals.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. C10152)

Bendick C, Schmidt-Westhausen AM, Reichart PA, Samaranayake LP
University of Health Sciences, Phnom Penh, Cambodia

BACKGROUND: Although Human Immundeficiency Virus (HIV) infection is endemic in Southeast Asia, data on oral mycotic flora in this disease in Asians are sparse. Aim of this study was to determine the prevalence of Candida species in HIV-infected Cambodians with oral candidiasis, unexposed (Group 1) and exposed to antimycotics (Group 2) and a healthy population (Group 3).

METHODS: In 161 HIV patients with oral candidiasis (Group 1: 121 pts.; Group 2: 40 pts.) and in 81 controls (Group 3) swab samples of tongue and palate were obtained.

RESULTS: Oral candidiasis was detected in 100% and 70% of Group 1and 2, respectively. Candida spp. were isolated from 91% and 100% of Group 1 and 2, respectively and from 79% of controls. C. albicans was the most common with non-albicans species, such as C. tropicalis and C. krusei being notable.

CONCLUSIONS: Our data indicate that variants of oral candidal infections in HIV disease are similar to that seen in the pre-HAART era. The particularly high rate of C. krusei isolation in all groups is noteworthy.

Keywords: AEGIS, Candidiasis, Oral, HIV Seropositivity, Prevalence, Candida, HIV Infections, Candidiasis, Mouth, Antiretroviral Therapy, Highly Active, Acquired Immunodeficiency Syndrome, Mouth Diseases, Asia, Southeastern, Humans, epidemiology

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C10152