15th International AIDS Conference Bangkok, Thailand - July 11-16, 2004

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. C10097)

Burq AI
Canadian International Community Support Foundation, Toronto, Canada

METHODS: The study in two steps was made with sixteen patients. The patients were with an unintentional weight loss of 5-25% of their ideal body weight Nutritional status was determinated by percentage of lost body weight and body mass index. Step 1 purpose was to correct a decreased food intake with a high nutritional counseling with polimeric oral food supplements. Step 2 purpose was to overcome metabolic disorders with the introduction of a separate anabolic therapy with high dose of medroxiprogesterone acetate 1000 mg/day or megestrole acetate 320 mg/day. Step 1 was followed by at least four weeks and a maximum of twelve weeks. In case of inefficiency of step 1, patients go to step 2 during eight weeks. A followup assessment was done four weeks after the study period.

RESULTS: Ten patients were evaluable, three dropped from study, one died, and one developed an opportunistic infection and one was not traceable. A stratified analysis identified three groups: A: 5-10%, B: 11-19%, C: 20-25%. Subjects in group A did not follow step 2 because of positive response to nutritional counseling. Subjects in group B&C needed nutritional intervention as in Step 2. During the follow up period, group B&C subjects lost weight gained when therapy was discontinued.

CONCLUSION: Nutritional therapy should begin earlier in course of infection because percentage of body weight gain is nearly 100% of the body weight losses.

040711
C10097

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