AEGiS-15IAC: Pharmacokinetics of indinavir in Koreans compared with Caucasians.

15th International AIDS Conference

Bangkok, Thailand - July 11-16, 2004

Pharmacokinetics of indinavir in Koreans compared with Caucasians.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. B10422)

Choi JY, Chang KH, Park YS, Cho CH, Shin SY, Han SH, Choi SH, Chin BS, Park YS, Song YG, Kim JM
AIDS Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea

BACKGROUND: Metabolic complications of indinavir, such as lipodystrophy or hyperlipidemia, are rare in Koreans. We evaluated whether the pharmacokinetic parameters of indinavir in Koreans and Caucasians differ. Materials and

METHODS: Indinavir 800 mg was administered orally to eight healthy male Koreans and four healthy male Caucasians. Indinavir levels in serum were quantified using liquid-liquid extraction followed by high performance liquid chromatography with UV detection. Parameters such as AUC (area under the concentration-time curve), Cmax (maximum concentration in plasma), Tmax (time to reach maximum plasma concentration), or T1/2 (half life) in the two populations were compared.

RESULTS: Plasma concentrations of indinavir were similar in both groups. No significant differences were observed in the pharmacokinetic parameters of indinavir in Koreans and Caucasians.

CONCLUSIONS: The pharmacokinetic parameters of indinavir in Koreans were similar to those of Caucasians in this small-scale study. Further study upon the metabolic complications of indinavir is needed in these two ethnic groups. [table: see text]

Keywords: AEGIS, Indinavir, Asian Continental Ancestry Group, European Continental Ancestry Group, Area Under Curve, Therapeutic Equivalency, Biological Availability, Half-Life, Chromatography, High Pressure Liquid, Male, pharmacokinetics

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B10422