AEGiS-15IAC: Management of HIV - 1 infection with multi various ART treatment - A medical study about a clinical care centre.

15th International AIDS Conference

Bangkok, Thailand - July 11-16, 2004

Management of HIV - 1 infection with multi various ART treatment - A medical study about a clinical care centre.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. B10173)

Rajasekaran VN
Meenakshi Mission Hospital and Research centre, Madurai, India

OBJECTIVE: To evaluate the treatment outcome amongst HIV 1 positive patients with a combination of ART drugs under the protocol given by CDC, Atlanta. Design: The study population comprised of 150 patients admitted in the AIDS clinic run by MMHRC. Prior to treatment, the clinical history, personal particulars. 10 ml of venous blood was also obtained from each patient and the blood sample was assayed for CD4 cell count viral load levels to obtain as baseline values. Patients were subsequently placed in to 3 groups. 1st group setting 3 drug combination (Zidovidine+Lamividin+Indinovir) and 2nd group is setting two drug combinations (Zidovidine+Lamividin) and 3rd group is getting Stavexin. At each sampling intervel, the body weight and any manifestation of opportunistic infections were recorded for each patient. All the data were collected at the end of the six months treatment and analyzed, used in SPSS package.

RESULT: The result showed that between the baseline and the 24th week, the mean body weight of the 1 group were increased by 6.1.kg, the frequency of opportunistic infections reduced by 240 cell/ml the viral load level declined by 1.7 log while 16% experienced drug associated side effect. The second group the mean body weight increased by 4.5 kg, the frequency of opportunistic infection reduced by 58%, the mean CD4 cell counts increased by 210 cell/ml, the viral load level declined by 1.2 log while 27% experienced drug associated side effect. The third group the mean body weight increased by 4.1 kg, the frequency of opportunistic infection reduced by 50%, the mean CD4 cell counts increased by 200 cell/ml, the viral load level declined by 1.1 log while 35% experienced drug associated side effect. To conclude, single drug therapy will be the optimum choice of our patients which give equal results as combined drugs & also economically affordable. The single drug regimen will be a best choice and bring effective results.

Keywords: AEGIS, HIV Infections, CD4 Lymphocyte Count, Viral Load, HIV-1, Antiretroviral Therapy, Highly Active, Acquired Immunodeficiency Syndrome, Humans, therapy, organization & administration, drug therapy

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B10173