AEGiS-15IAC: Haematogical and Biochemical Response to treatment of HIV-1 infection with a combination of Nevirapine + Stavudine+ lamivudine in Lagos Nigeria.

15th International AIDS Conference

Bangkok, Thailand - July 11-16, 2004

Haematogical and Biochemical Response to treatment of HIV-1 infection with a combination of Nevirapine + Stavudine+ lamivudine in Lagos Nigeria.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. B10064)

Odunukwe NN, Idigbe EO, Adewole TA, Onwujekwe DI, Audu R
Clinical Research Centre Nigerian Instituteof Medical Research, Fedral Ministry of Health, Lagos , Nigeria

BACKGROUND: To evaluate the effect of a combination of Nevirapine +Stavidine +Lamivudine on Heamatogical and Biochemical values of HIV-1 positive patients in Lagos. Methods and materials: Fifty patients who met the enrollment criteria for accelerated clinical trial were studied. Ten millimeters of blood was taken from each patient at first visit for basic heamatological, biochemical values, Viral load and CD4 cell counts. All the values were repeated at 12weeks, and 24weeks, after commencement of drug treatment. All the data were analyzed using Epi-info version 6.4D.

RESULTS: The mean creatinine results were 1.2±0.68, 1.2± 0.7, 1.04 ±0.3 at (Baseline, 12weeks and 24 weeks respectively). Serum amylase 37.9 ± 15.1, 38± 23.9 and 24.3 ± 11.6. Triglycride 95.2± 48.3, 92.38 ± 54.3 and 78.0 ± 35.6. Serum bilirubin 0.18±0.09, 0.29±0.28 and 0.33±0.24. Alanine transaminase (ALT) 9.9±3.3, 15.1 ± 9.0, 14.1± 9.3. Serum Aspartate transaminase (AST) 8.2±6.2, 9.4±5.2, 9.1± 6.0. Erythrocyte sedimentation rate 53.3±41.8, 48.2±40.6 and 28.6±20.7. Haemoglobin 12.3±1.5, 12.4±2.1 and 13.2±1.4. Erythrocyte sedimentation rate 53.3±41.8, 48.2±40.6 and 28.6±20.7. Packed cell volume 36.8±4.5, 37.6±4.8, and 40.3±3.3. Total WBC 4.2±1.0, 5.0±1.5 and 4.6±1.0. (Baseline, 12weeks and 24 weeks respectively). On comparison between baseline and 12th week results, only PCV, Hb, serum bilirubin, serum alanine transaminase, and total WBC, were significantly higher at 12th week (P<0.5). On comparison between 12th week and 24th week results, all parameters were similar except Hb and PCV (which were significantly higher at 24th week) while ESR, was significantly lower at 24th week. (P< 0.5).

CONCLUSION: It was concluded that Nevirapine + Stavudine +Lamivudine combination results in improved haematological values in HIV/AIDS patients. The effect of the drug combination can be monitored with clinical symptoms and haematological values in resource poor setting.

Keywords: AEGIS, Stavudine, Nevirapine, Lamivudine, HIV Infections, CD4 Lymphocyte Count, HIV-1, Viral Load, Acquired Immunodeficiency Syndrome, Drug Therapy, Combination, HIV Seropositivity, Drug Combinations, Nigeria, Humans, therapy, drug therapy

040711
B10064