AEGiS-15IAC: HIV-1 and hepatitis B and C multiple infection are common in Cameroon.

15th International AIDS Conference

Bangkok, Thailand - July 11-16, 2004

HIV-1 and hepatitis B and C multiple infection are common in Cameroon.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. B10058)

Ngansop Charlotte NC, Kobayashi Eiji KE, Ndembi Nicaise NN, Takemura Taichiro TT, Ido Eiji IE, Takeda Katsumichi TK, Hayami Masanori HM, Kaptue Lazare KL, Ichimura Hiroshi IH
Faculty of medicine and biomedical sciences, university of yaounde I yaounde Cameroon, Yaounde, Cameroon

BACKGROUND: There has been reported about the prevalence of hepatitisCvirus (HCV) and hepatitis B virus(HBV)in Cameroon. HCV antIbody tets have been reported to miss as much as 39% of HCV infections in prson co-infected with HIV. In this study, to know HIV whether HIV infection can influence onthe infection of HBV or HCV, we investigated the prevalence of HBV and HCV among HIV-positive and HIV-negative patients in Cameroon. Subjects and

METHODS: Plasma of 637 hospitalized patients aged from 15 to 87in remote village of the equatorial rainforets of Cameroon. Was screened for anti-HIV antibodies with AxSYMHIV-1/HIV2(Microparticle EIA, Abbott Laboratories)and Determine HIV-1/2(Immuno-chromatography,Abbott Laboratories). Hepatitis B surface antigen(HBsAg)was tested with HCVPHAkit( third generationpassive hemoagglutination test,Abbott,Japan).

RESULTS: Out of the 637 patients, 323(50.7%),51(8.0%)and 97(15.2%) were positive for HIV Ab,HBsAg and HCV Ab, respectively. While prevalence of HBV was significantly higherin HIV-positive patients(10.5%; 34/323) than in HIV-ngative ones(5.4%; 17/314)(p=0.026), prevalence of HCV was significantly lower in HIV-positive patients(12.1%;39/323) than in HIv-negative ones (18.5%;58/314)(p=0.033). Two patients were triply infected with HIV,HBV and HCV, and patient was dually infected with HBV and HCV.

CONCLUSION: These results suggest that HIV infection can be a co-factor for HBV infection, but that HCV infection may occur independently infectipon in Cameroon

Keywords: AEGIS, Hepatitis B virus, Hepatitis B, HIV-1, HIV Infections, HIV Seropositivity, Hepatitis C Antibodies, Hepatitis B Surface Antigens, Acquired Immunodeficiency Syndrome, HIV, Hepatitis B Antibodies, Prevalence, Communicable Diseases, Hepacivirus, HIV-2, HIV Antibodies, Cameroon, Japan, Humans, immunology

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B10058