AEGiS-15IAC: Epidemiology and natural history of HPV infection in HIV positive women A prospective study.

15th International AIDS Conference

Bangkok, Thailand - July 11-16, 2004

Epidemiology and natural history of HPV infection in HIV positive women A prospective study.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. A10400)

Pujol de la Llave E, Santos Mora JC, Palomeque Fuentes F, Borrero Martin JJ, Ruano Garcia A, Conde Garcia J
Hospital Juan Ramon Jimenez, Huelva, Spain

BACKGROUND: We have been carried out a prospective study on 59 women with HIV infection that evaluates the epidemic and risk factors implied in Papilomavirus (HPV) infection, as well as the relationship among immunodeficiency caused by the VIH and HPV infection or cervical pathology.

METHODS: 59 HIV positive women were selected and we carry out two tests, cytology and cervical HPV detection in two times separated at least 6 months. The epidemic and risk factors associated with HPV infection and cervical pathology were evaluated (civil state, employment, economic level, level of studies, antecedents of prostitution, first sexual intercourse at early age, smoker and drugs in the past, couple with genital wart, frequent use of condom, parity, CD4 count and viral load).

RESULTS: n=59. Mean age=34,19. 35,6% was HPV positive in the first test. There was a bigger number of unemployed women in HPV positive group (69,6% vs 38,9%), smaller level of incomes (95,7% were<600 EUR in HPV positive vs 86,1% in negative) and low levels of studies (91,3% of HPV positive with elemental studies vs 86,1%). HPV positive women turned out to have a bigger percentage of prostitution antecedent than HPV negative (34,8% vs 19,4%), as well as more use of drugs in the past (82,6% vs 47,2%; p=0,006), first sexual intercourse before 18 years (82,6% vs 72,2%), couple with genital wart (43,5% vs 19,4; p=0,045), little use of condom (13% vs 50%; p=0,003), and more parity (13% vs 2,8%; p=0,024). HPV 18 were the most common subtype (9 cases). The mean of CD4/mm³ count was 287,48 in HPV positive women in front of the 517,47 in negative (p=0,011). The mean of viral load was 94.302,43 in HPV positive vs 46.097,97 (p=0,345).

CONCLUSIONS: The archetype of HPV infected woman was an unemployed married woman with low level of incomes and elemental studies. Risk factors more associated to HPV infection were antecedents of drugs, multiparity and little use of condom. We find a high prevalency of HPV infection, fact that is also related in our study with low CD4 counts but not significantly with viral load.

Keywords: AEGIS, Papillomavirus, Human, HIV Seropositivity, Prospective Studies, Communicable Diseases, CD4 Lymphocyte Count, HIV Infections, Risk Factors, Condylomata Acuminata, Viral Load, Prostitution, Condoms, Humans, Female, epidemiology

040711
A10400