AEGiS-15IAC: Functional activity of cytotoxic cells in HIV-infected patients with different HAART efficiency.

15th International AIDS Conference


Bangkok, Thailand - July 11-16, 2004

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Functional activity of cytotoxic cells in HIV-infected patients with different HAART efficiency.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. A10355)

Shemshura AB, Sveshnikova LV, Poddubskaya SY, Shishaeva OB, Ponomarenko YV
Rostov Research Institute of Microbiology and Parasitology, Rostov-on-Don, Russian Federation

BACKGROUND: Cellular immune responses play a central role in controlling HIV-1 infection. The effect of altering functional activity of cytotoxic cells on suppression of viral replication during HAART in HIV-1-infected patients was assessed.

METHODS: CD4, CD8 T-cell counts, CD56CD16 NK count, CD95, HLA DR, FasL expression on various lymphocytes subpopulations and viral loads were measured in 48 HIV-infected patients at baseline and 12 and 24 weeks after HAART beginning.

RESULTS: Patients with poor viral response (viral rebound during 12 weeks after therapy beginning) exhibited lower baseline level of CD8+FasL+ (95% CI, 5-18%), CD56+CD16+FasL+ cells (95% CI, 2-11%), and higher level of CD8+CD95+ cells (95% CI, 19-26%), in comparison with group of the successfully treated patients (95% CI, 11-24%; 7-15% and 14-23%, respectively). At 24 weeks after therapy start patients with strong long viral suppression, differently from compared group, demonstrated a faster reduction of CD8+CD95+ cells, gradual decrease of activation markers expression and stable high CD56+CD16+FasL+ count.

CONCLUSIONS: Remote HAART efficiency in HIV-1-infected patients depends on cellular immune responses and associated with adequate functional activity of cytotoxic cells. The evaluation of cell activation and apoptotic markers can be useful at definition of therapy prognosis.

Keywords: AEGIS, Antiretroviral Therapy, Highly Active, Acquired Immunodeficiency Syndrome, HIV Seropositivity, HIV Infections, HIV-1, Killer Cells, Viral Load, CD8-Positive T-Lymphocytes, Virus Replication, Antigens, CD95, Membrane Glycoproteins, Antigens, CD8, FasL protein, Humans, pathogenicity, virology, immunology

040711
A10355

Copyright © 2004 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.