AEGiS-15IAC: Cytotoxic T lymphocyte cross reactions of chinese HIV/AIDS patients to HXB2 gag and nef peptide pools.

15th International AIDS Conference


Bangkok, Thailand - July 11-16, 2004

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Cytotoxic T lymphocyte cross reactions of chinese HIV/AIDS patients to HXB2 gag and nef peptide pools.

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. A10260)

li TS, Zhang HW, Qiu ZF, Han Y, Wang AX
Centers for Disease Control and Prevention, Beijing, China

BACKGROUND: HIV-1 C and B' subsets are the prodimonant HIV-1 strainis in China, and the cytotoxic T lymphocyte responses (CTL) in Chinese HIV/AIDS patients is unclear. HXB2 is one of the predominant isolates HIV-1 strain in Europe and America but it is not known whether it can induce a significance CTL in Chinese HIV/AIDS patients in spite of the difference of the HIV-1 strain. We want to detect the cross reactions which is important to the design of HIV vaccines in China.

METHODS: The Chinese HIV/AIDS patients were divided into two groups. One is 9 AIDS patients, and another is 7 long-term nonprogressors (LTNPs). CTL responses were examined in all patients by ELISPOT method, and using gag and nef peptide pools of HXB2 isolate as stimulators. CD4+ cell counts, CD8+ cell counts and viral loads were also examined in all patients.

RESULTS: The breadth and magnitude of CTL responses in LTNPs group is greater than that in AIDS group (p<0.01). There is a significance positive correlation between magnitude of CTL and CD4+ T cell counts and a significance negative correlation between CTL responses and mean viral load (Fig 1). The peptide pools recognized by AIDS patients were different with those by LTNPs.

CONCLUSIONS: There is a considerable degree of CTL cross-recognition to the HXB2 Gag and Nef peptide pools in Chinese HIV/AIDS patients. So, HIV-1 vaccines based on a single clade in Europe that can induce might also be used in Chinese HIV/AIDS patients.

Keywords: AEGIS, Acquired Immunodeficiency Syndrome, HIV Seropositivity, Genes, gag, T-Lymphocytes, Cytotoxic, HIV-1, Cross Reactions, Viral Load, AIDS Vaccines, CD4 Lymphocyte Count, CD8-Positive T-Lymphocytes, Peptides, Europe, China, Americas, Humans, genetics, immunology

040711
A10260

Copyright © 2004 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.