15th International AIDS Conference Bangkok, Thailand - July 11-16, 2004

Int Conf AIDS 2004 Jul 11-16; 15:(abstract no. A10025)

Zhu B, Chen YG, Wu NP, Chen Z
The institue of infectious disease ,the 1st hospital of Zhejiang University, Hangzhou, China

BACKGROUND: To study the co-infection of HBV and HCV in HIV-infected patients transmitted by blood and sexual intercourse.

METHODS: HBV marker and anti-HCV were detected by ELISA in 49 HIV-infected homosexuals from Germany and 62 Chinese patients infected by blood. PCR (or RT-PCR) was used to detect HBV DNA and HCV RNA in the patients testing HBV marker and anti-HCV positive.

RESULTS: the positive rate of HBV marker and anti-HCV in 49 German HIV-infected homosexuals was 53% (26/49) and 6.1% (3/49), respectively. The corresponding rate in 62 Chinese HIV-infected patients was 53.2% (33/62) and 95.2% (59/62), respectively; HBV-DNA was positive in 4 out of 26 Chinese patients testing HBV marker positive and HCV RNA was all negative in 3 German patients testing anti-HCV positive; HBV-DNA was positive in 4 out of 33 Chinese patients testing HBV marker positive and HCV RNA was positive in 34 out of 59 Chinese patients testing anti-HCV positive; HCV infection was much higher in HIV-infected patients transmitted by blood than in those by homosexual intercourse(P<0.001). But these 2 groups had no big difference in HBV infection.

CONCLUSIONS: HCV infection risk is different in different spreading ways. HIV patients infected by blood got HCV infection much more easily, but the acquirement of HBV infection in this way was not as easy as in other ways, which indicated that the molecular mechanisms for HBV and HCV dissemination were different. Keywords: HIV homosexual transmission by transfusion HBV HCV co-infection

040711
A10025

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