AEGiS-14IAC: 5 years of reproductive assistance with ivfet in HIV discordant couples.

14th International AIDS Conference


Barcelona, Spain - July 7-12, 2002

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5 years of reproductive assistance with ivfet in HIV discordant couples.

Int Conf AIDS 2002 Jul 7-12; 14:(abstract no. LbPeD9040)

Ravizza M, Foina S, Seveso A, Magiarotti L, Ierardi MG, Serafini P, Pariani S, Ragusa G, Pardi G
Department of Obstetric and Gynaecology, San Paolo Hospital, University of Milan, Milan, Italy

BACKGROUND: Sexual transmission remains by far the predominant mode of hiv infection. Since 1990 we have been assisting hiv discordant couples (men hiv positive and women hiv negative) with sperm washing to reduce risk of hiv transmission by intrauterine insemination (aih) and in vitro fertilisation (ivfet). Aim of this study is to determine in vitro fertilisation outcomes in 165 couples.

METHODS: 165 couples underwent ivfet from 1997 to February 2001. Inclusion criteria consisted in AIH failure, female age over 35 years, tubal factor, male factor; all women were HIV negative. Ovarian stimulation was performed with standard protocols used for sterile patients. Semen was prepared with Percoll gradient washing and swim-up technique and tested, before oocytes insemination, using pcr Nasba technique. Women were tested for hiv 6 and 12 months after ivfet and the offspring at birth and at twelve months life.

RESULTS: Pregnancy rate was 24.9% (64 pregnancy/ 257 embryotransfers): 37deliveries, 52 livebirths, 7 ongoing pregnancies, 16 miscarriages, 2 ectopic pregnacies, 2 voluntary interruptions for foetal malformations. No seronconversions in women or offspring. Indications to ivfet: AIH failure 32%, male factor 26%, tubal factor 25 %, female age 13 %,ovarian factor 4%. 3 of the 282 treated semen resulted positive to pcr.

CONCLUSIONS: Ivfet is a safe mean of conceiving for HIV discordant couples. Abnormal semen is frequent in seropositive men: this is a critical information when selecting the most suitable technique for conceiving. Sperm washing and PCR test are today the only available methods to minimize the infection risk in these couples.

Keywords: AEGIS, HIV, HIV Infections, HIV Seropositivity, Insemination, Artificial, Homologous, Semen, HIV Antibodies, Spermatozoa, HIV Seronegativity, Human, Female, Male, In Vitro, Pregnancy, immunologyKWDaegis,hiv,hivinfections,hivseropositivity,insemination,artificial,homologous,semen,hivantibodies,spermatozoa,hivseronegativity,human,female,male,invitro,pregnancy,immunology

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LbPeD9040

Copyright © 2002 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.