AEGiS-13IAC: Intracranial suppuration in HIV-positive patients.

13th International AIDS Conference


Durban, South Africa - July 9-July 14, 2000

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Intracranial suppuration in HIV-positive patients.

Int Conf AIDS 2000 Jul 9-14; 13:(abstract no. WePeC4449)

Nathoo N, Nadvi SS, Jogessar V
N. Nathoo, Wentworth Hospital, Department of Neurosurgery, Private Bag Jacobs 4026, Durban, South Africa, Tel.: +27 31 460 51 03, Fax: +27 31 461 28 97, E-mail: nathoo@wwh.und.ac.za

BACKGROUND: This study was undertaken to determine the influence of HIV on the clinical course and outcome of patients with intracranial suppurative disorders (abscesses, empyemas and ventriculitis)

METHODOLOGY: A retrospective analysis of 18 785 patients admitted from 1991 to 1999 to our institution identified 1289 patients (6.86%) with intracranial suppuration of which 33 patients (2.6%) were found to be sero-positive for HIV. The in-patient notes of these patients were analysed with respect to clinical, radiological, bacteriological, surgical and outcome data. CD4 counts were performed in 8 patients only.In addition comparative analysis with 712 brain abscesses and 692 subdural empyemas sero-negative for HIV (admitted from 1983 to 1997) were performed.

RESULTS: Thirty-three sero-positive patients (18 abscesses, 3 ventriculitis and 12 subdural empyemas) were identified. Except for a single patient with multiple small abscesses,all patients underwent surgery (96.7%). Comparative data analysis of brain abscesses revealed a significant difference (p > 0.05) in duration of symptoms, multiplicity, mortality and hospital stay. Analysis of subdural empyemas revealed a significant difference in age only.

CONCLUSION: Intracranial suppurative disorders are uncommon in HIV-positive patients. HIV-positive patients with brain abscesses have a poorer outcome than sero-negative patients

Keywords: AEGIS, Suppuration, Empyema, Subdural, HIV Infections, Brain Abscess, HIV Seropositivity, CD4 Lymphocyte Count, Empyema, Retrospective Studies, HumanKWDaegis,suppuration,empyema,subdural,hivinfections,brainabscess,hivseropositivity,cd4lymphocytecount,empyema,retrospectivestudies,human
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WePeC4449

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