AEGiS-13IAC: Clinical pattern of tuberculosis in HIV sero+ive and HIV sero-ive subjects - a study in Calcutta / West Bengal, India.

13th International AIDS Conference


Durban, South Africa - July 9-July 14, 2000

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Clinical pattern of tuberculosis in HIV sero+ive and HIV sero-ive subjects - a study in Calcutta / West Bengal, India.

Int Conf AIDS 2000 Jul 9-14; 13:(abstract no. TuOrB275)

Dey SK, Pal NK
S.K. Dey, P-41/1, Nat Abar Pal Road, Howrah 71 11 05, India, Tel.: +91 33 651 34 64, Fax: +91 33 554 5741

BACKGROUND: India, home to 3.5 million HIV +ives (Sero +vity rate 25.3/1000- Oct. '99 among reported 89,840), also has high TB infection rates (50% in adults). As TB is the commonest opportunistic infection (around 60%) among HIV +ives, a comparative study of disease pattern (among sero -ive and sero +ive subjects) is undertaken.

METHODS: Between '93-'99, 1000 TB cases HIV -ive (72.7% males) and 102 TB cases HIV +ive (86.3% males) from Calcutta/North Bengal Region of state-West Bengal, (low level epidemic zone) were studied.

RESULTS: The presenting clinical pattern is summarised below: TB Cases HIV -ive HIV +ive Odds ratio (C. limit) p value Pulm TB (PTB) 735 (73.5%) 50 (49%) 0.35 (0.07-1.41) >0.001 Extra-pulm (Ep) TB* 215 (21.5%)** 35 (34.3%)*** 1.91 (0.88-2.94) >0.05 PTB + EpTB 50 (5%) 17 (16.7%) 3.80 (2.75-4.85) >0.001 Total Nos. 1000 (100%) 102 (100%) * Bilateral hilar lymph adenopathy shown in Ep gp (No post mortem done). ** Includes 3 miliary (.003%) *** Includes 2 miliary (1.9%). Ep site involvement - among HIV -ive, Ep gp (265) and HIV +ive, Ep GP (52), lymph gland affected 146 & 45 (p > 0.001) (in favour of HIV +ives) followed by pleura-79 & 7, others-37 & 7 (1 pericardial effusion) respectively. In HIV +ves 2-3 sites involved simultaneously.

CONCLUSION: EpTb - lymph gland, commonest site in both sero -ve & sero +ve groups, more in the latter one. PTB with EpTB involvement is significantly higher in HIV +ves & should arouse suspicion for compulsory HIV Ab testing even in low prevalence epidemic zones/resource constraint settings. Diffuse bilateral pulmonary infection in chest X-ray is commonly seen in HIV +ves and calls for compulsory HIV Ab testing. Results highly significant statistically.

Keywords: AEGIS, India, Tuberculosis, HIV Seropositivity, Tuberculosis, Pulmonary, HIV Infections, Prevalence, Respiratory Tract Infections, Odds Ratio, Human, Male, AdultKWDaegis,india,tuberculosis,hivseropositivity,tuberculosis,pulmonary,hivinfections,prevalence,respiratorytractinfections,oddsratio,human,male,adult
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TuOrB275

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