AEGiS-12IAC: Ritonavir + saquinavir (RIT + SAQ) salvage therapy in antiretroviral-experienced patients.

12th International AIDS Conference


Geneva, Switzerland - June 28-July 3, 1998

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Ritonavir + saquinavir (RIT + SAQ) salvage therapy in antiretroviral-experienced patients.

Int Conf AIDS 1998 Jun 28-Jul 3; 12:75 (abstract no. 12310)

Scerpella E, Moreno JN, Dashefsky M, Jayaweera DT, Boulanger C, Rodriguez AE
University of Miami, FL 33136, USA.

We describe the results obtained using the double protease combination of Ritonavir plus Saquinavir (RIT + SAQ) as salvage therapy in 23 antiretroviral-experienced patients attending our outpatient clinic at Jackson Memorial Hospital, Miami, Florida. PATIENT CHARACTERISTICS: Mean age 38 years (range: 21-65). Sex: 14 males, 9 females. Staging: 14 AIDS, 9 HIV-infection. Mean prior duration of therapy was 23 months (range: 2-91). All patients have been previously treated with most nucleosides available, and 17/23 had previously used protease inhibitors (indinavir, saquinavir) for various periods of time. Median baseline CD4: 149 cells/mm3 (range: 7-609). Mean baseline viral load: 4.66 logs (45,708 copies/mL). Response to treatment with RIT + SAQ was defined as a viral load decrease > 0.5 logs.

RESULTS: Fifteen (65%) of the 23 patients that started RIT + SAQ responded to treatment (viral load decrease > 0.5 logs). Failures (8/23) were mostly due to noncompliance and intolerance of medications. Eleven (73%) of the 15 responders became undetectable at one point. Eight of the 11 remain undetectable, for periods of up to 17 months of follow-up. The mean decrease in viral load among responders was more than 2 logs. We analyzed the characteristics that predict response to RIT + SAQ in these patients.

CONCLUSION: Treatment with RIT + SAQ is a viable alternative for nucleoside-experienced and protease-experienced patients. The majority of responders in this series reached undetectable levels of virus, and have remained undetectable since.

Keywords: AEGIS, Saquinavir, Ritonavir, Viral Load, Salvage Therapy, Indinavir, HIV Infections, Protease Inhibitors, Florida, Human, Female, Male, ICA12KWDaegis,saquinavir,ritonavir,viralload,salvagetherapy,indinavir,hivinfections,proteaseinhibitors,florida,human,female,male,ica12
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