AEGiS-12IAC: Prevalence of mutations that confer resistance to RT inhibitors among drug naïve HIV-positive blood donors in Sao Paulo/Brazil.

12th International AIDS Conference


Geneva, Switzerland - June 28-July 3, 1998

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Prevalence of mutations that confer resistance to RT inhibitors among drug naïve HIV-positive blood donors in Sao Paulo/Brazil.

Int Conf AIDS 1998 Jun 28-Jul 3; 12:16 (abstract no. 11168)

Sabino EC, Saez-Alquezar A, Barreto CC
Fundacao Pro-Sangue/HSP, Brazil.

BACKGROUND: Since 1989, RT inhibitors have been provided by the Brazilian Ministry of Health to HIV-infected patients. Because monotherapy was predominantly used in the first years of the program, one should expect selection for RT-inhibitors resistant mutations. Hence, it is important to monitor the frequency of these mutations in order to guide medical and Government decisions in relation to HIV treatment. The aim of this study was to determine the frequency of mutations that confer resistance to RT inhibitors among blood donors diagnosed serologically to be HIV infected.

METHODS: Samples were obtained between 1995 and 1996 from HIV-positive blood donors at Fundac ao Pro-Sangue Hemocentro de Sao Paulo; none of them were under antiretroviral therapy. The presence of mutations that confer resistance to RT inhibitor were determined by LIPA HIV-1 RT (Murex/Innogenetics, Gent/Belgium).

RESULTS: Of the 59 samples tested, 7 (12%) had a single mutation that confer resistance to HIV inhibitors: 5 were K70R, 1 was M184V, and 1 was T215F. One individual (1.5%) had two mutations, K70R and M184V. There were 13 (22%) samples that did not hybridize to one of the 5 codons evaluated by the test, suggesting that Brazilian samples may be more variable in this region.

CONCLUSION: The frequency of mutations that confer resistance to RT inhibitors is around 13.5% among drug naïve HIV positive blood donors in Sao Paulo/Brazil.

Keywords: AEGIS, Prevalence, HIV Infections, Blood Donors, HIV-1, HIV-1 Reverse Transcriptase, Mutation, HIV Seropositivity, Codon, Brazil, Belgium, Human, epidemiology, antagonists & inhibitors, genetics, ICA12KWDaegis,prevalence,hivinfections,blooddonors,hiv-1,hiv-1reversetranscriptase,mutation,hivseropositivity,codon,brazil,belgium,human,epidemiology,antagonists&inhibitors,genetics,ica12
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