AEGiS-12IAC: Interaction of HIV-1 and hepatitis B virus (HBV) in mixed infection.

12th International AIDS Conference


Geneva, Switzerland - June 28-July 3, 1998

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Interaction of HIV-1 and hepatitis B virus (HBV) in mixed infection.

Int Conf AIDS 1998 Jun 28-Jul 3; 12:14 (abstract no. 11160)

Antonenko SV, Barbasheva EV, Murashko EV, Scherbinskaya AM
Res. Inst. Epidemiology & Infection Disease, Kiev, Ukraine.

OBJECTIVES: To study some events conserning of HIV-1 and HBV interaction in in vivo mixed infection.

METHODS: The blood samples of HIV-infected patients with chronic hepatitis B were tested for HIV-1 proviral DNA level in PBMCs, HBV DNA level in plasma using a quantitative PCR, HIV-1 antigen p24 level in plasma by ELISA. The results were compared with the clinical stages of disease. Some biological properties of clinical HIV-1 isolates were detected by indirect immunofluorescence, reverse transcriptase reactions, PCR, light microscopy.

RESULTS: HIV-infected patients with chronic hepatitisB who had high amounts of HBV DNA had significant higher amounts HIV-1 proviral DNA. They were more frequently HIV-1 p24 antigen positive compared to patients with low amounts of HBV DNA. Comparative analisys of biological patterns HIV-1 isolates from HIV-1 positive patients in the periods activation of chronic HBV infection shows this isolates to posses significantly higher infective, replicative and cytocide activity. The data obtained testifly to the mutual influence of the HIV-1 and HBV upon the mixed infections.

Keywords: AEGIS, Hepatitis B Virus, HIV-1, HIV Infections, Hepatitis B, Chronic, HIV, Polymerase Chain Reaction, Enzyme-Linked Immunosorbent Assay, Human, ICA12KWDaegis,hepatitisbvirus,hiv-1,hivinfections,hepatitisb,chronic,hiv,polymerasechainreaction,enzyme-linkedimmunosorbentassay,human,ica12
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