AEGiS-10IAC: Clinical regression and lack of progression non-Hodgkin's lymphoma (Burkitt type) during treatment with ganciclovir (GCV) in a HIV (+) patient with cytomegalovirus retinitis.

10th International AIDS Conference


Yokohama, Japan — Aug 7-12, 1994

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Clinical regression and lack of progression non-Hodgkin's lymphoma (Burkitt type) during treatment with ganciclovir (GCV) in a HIV (+) patient with cytomegalovirus retinitis.

Int Conf AIDS 1994 Aug 7-12; 10:177 (abstract no. PB0135)
Luna N, Bistoni A, David DO; Rawson Hospital, Cordoba, Argentina.

OBJECTIVE: To report a case of clinical regression and lack of progression on a Non-Hodgkin's Lymphoma (Burkitt type) during treatment with Ganciclovir (GCV) in a HIV (+) patients with cytomegalovirus retinitis. CASE REPORT: A 35 years old patient, HIV(+), stage C3 (CDC), with a facial tumor that modifies the face is reported. The physical examination revealed a friable tumoral mass in both nasal cavities. Biopsy and immunohistochemical tests confirmed Burkitt Lymphoma. Opthalmologic control revealed cytomegalovirus retinitis. Brain, thorax and abdomen computed tomographic scaning did not show any evidence of others tumoral masses. He was receiving antiretroviral therapy with DDI before the tumor appeared as regular treatment for the AIDS, during the development of the reported tumor he received acyclovir with no avail. Treatment with GCV 10 mg/kg/d during 21 days was started followed by 5 mg/kg/d 3x/week and IV gammaglobulin 3 gr q4 weeks. At present retinitis did not show any clinical sign of recurrence after 3 weeks of treatment. There was a reduction of the tumor and it has not progressed in 3 months.

CONCLUSIONS: Treatment with Ganciclovir was safe and able to reduce the tumor mass in a patient with Burkitt Lymphoma.

Keywords: AEGIS, Cytomegalovirus Retinitis, Ganciclovir, Retinitis, Antiviral Agents, Acquired Immunodeficiency Syndrome, Didanosine, Burkitt Lymphoma, Neoplasm Staging, Reverse Transcriptase Inhibitors, HIV Protease Inhibitors, Recurrence, Salvage Therapy, Human, therapy, drug therapy, ICA10
940807
PB0135

Copyright © 1994 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.