AEGiS-08IAC: Frequency and clinical features of pulmonary infections with Mycobacterium xenopi (M. xenopi) in AIDS patients.

8th International AIDS Conference


Amsterdam, Netherlands — July 19-24, 1992

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Frequency and clinical features of pulmonary infections with Mycobacterium xenopi (M. xenopi) in AIDS patients.

Int Conf AIDS 1992 Jul 19-24; 8:55 (abstract no. PuB 7037)
Bergmann F, Schuermann D, Gruenewald T, Ruf B; 2nd Department of Internal Medicine, Rudolf Virchow University Hospital, Freie University Berlin, Germany.

OBJECTIVE: Frequency and features of AIDS-related mycobacterial infections due to M. xenopi were analysed.

METHODS: Charts of 948 HIV-infected patients from 1987-1991 were evaluated for the isolation of M. xenopi in clinical and/or postmortem specimens and related to clinical data. M. xenopi infections were separated into three groups: 1) primary pulmonary disease (PD), 2) disseminated disease with (DD+) or without pulmonary involvement (DD-), 3) colonization without disease (CO).

RESULTS: M. xenopi was detected in 9/948 patients (0.95%). All nine respiratory secretions were positive by culture; liver, spleen and lymph node tissue were involved in 3/9 cases, lung specimens were positive in 3/7 examined. Active disease (either PD or DD+/-) was present in 6/9 (66.6%) cases. Pulmonary involvement occurred in 5/6 (PD 2/9, DD+ 3/9), one had DD-. Three out of nine had CO. In patients with PD or DD+ the clinical symptoms were unspecific (fever, cachexia, weight loss) as seen in tuberculosis. Mediastinal lymph node enlargement and apical pulmonary infiltrations were seen. In disseminated disease also hepatosplenomegaly with abdominal lymphadenopathy was found.

CONCLUSIONS: M. xenopi infection is a rare complication in severely immunosuppressed AIDS patients and involves the lungs frequently. There is evidence that the clinical picture cannot be separated from other mycobacterial infections.

Keywords: AEGIS, Mycobacterium xenopi, Acquired Immunodeficiency Syndrome, Respiratory Tract Infections, Mycobacterium Infections, HIV Infections, Lung Diseases, HIV Seropositivity, Tuberculosis, Lung, HIV, Human, epidemiology, ICA8KWDaegis,mycobacteriumxenopi,acquiredimmunodeficiencysyndrome,respiratorytractinfections,mycobacteriuminfections,hivinfections,lungdiseases,hivseropositivity,tuberculosis,lung,hiv,human,epidemiology,ica8
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PuB7037

Copyright © 1992 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.