Two cases of basal-cell epithelioma in HIV-infected patients, with recurrence in one of them.
Int Conf AIDS 1991 Jun 16-21; 7:233 (abstract no. M.B.2207) Livrozet JM, Marchand C, Saint-Marc T, Garnier JL, Nicolas JF, Hermier C, Touraine JL; Hopital Edouard Herriot Lyon, France
Basal-cell epitheliomas are rare events among HIV seropositive patients. We report 2 cases, one of which recurred twice. A 35 year old male presented with necrotic herpes zoster and, on that occasion, was found to be HIV-seropositive. Eight months later, while being CDC stage IV C2 he presented aphasia and alexia due to thrombosis of the sylvius artery and was given azidothymidine treatment. He presented subsequently while having 93 CD4+ lymphocytes/mm3, an ulcerative lesion of the nose that histoligically proved to be a typical basal-cell epithelioma with pilar differentiation and a moderate cellular infiltration. A 39 year old man had suffered from herpes zoster at the age of 28 and 37. He was seen for a basal-cell epithelioma of the forearm while being CDC stage IV C2 and having 255 (CD4+ lymphocytes/mm3. One year later, an other basal-cell epithelioma was observed on the right scapula with a pagetoid aspect. In fact, these epitheliomas were the second and the third ones in this patient, and the first epithelioma (right arm) was treated in Ivory Coast, in 1984. The development of basal-cell epitheliomas may have been favoured by profound immunodeficiency in our patients. Because of very limited documentation of basal cell epithelioma in HIV-infected patients, the exact relationship between this tumor and this immunodeficiency, and the mechanism of development of both initial epithelioma and recurring tumors are still incompletely elucidated.
Keywords: AEGIS, Carcinoma, Basal Cell, Recurrence, CD4-Positive T-Lymphocytes, HIV Infections, Zidovudine, Centers for Disease Control and Prevention (U.S.), Neoplasm Recurrence, Local, HIV Core Protein p24, HIV Seropositivity, Herpes Zoster, Cote d'Ivoire, Human, Male, ICA7 910616
MB2207
