AEGiS-07IAC: Loss of antibody reactivity against cytomegalovirus during asymptomatic and late phases of HIV-1 infection.

7th International AIDS Conference


Florence, Italy — June 16-21, 1991

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Loss of antibody reactivity against cytomegalovirus during asymptomatic and late phases of HIV-1 infection.

Int Conf AIDS 1991 Jun 16-21; 7:29 (abstract no. M.A.30)
Fehniger TE, Converse P, Strannegard O, Ehrnst E, Maasho K, Sonnerborg A, Britton S; Karolinska Institute, Dept. of Infectious Diseases

OBJECTIVE: To define the patterns of antibody reactivity against CMV in HIV-1 infected subjects.

METHODS: The study group of CMV seropositive subjects included HIV+ clinically asymptomatic (asym: n=13), ARC/AIDS (n=7), and HIV- homosexual and non-homosexual adult subjects. IgG antibody reactivity was measured against intracellular and extracellular CMV antigens.

RESULTS: Regardless of their clinical status or peripheral T-lymphocyte values HIV+ subjects showed significantly lower reactivity against CMV nucleocapsid antigens and an antigen associated with virion particles of mol. wt. 28 kd. which were recognized by all CMV+ HIV- controls. Equivalent antibody reactivity was observed for all HIV-/HIV+ subjects with CMV infected fibroblast nuclei, however all HIV+ also showed high reactivity with uninfected fibroblast nuclei. The loss of antibody to the CMV nucleocapsids and 28 kd was most pronounced in asym HIV+ non-homosexual subjects, regardless of their HIV-1 infection clinical status.

CONCLUSIONS: Selective losses in specific anti-CMV reactivity occur frequently in subjects following HIV-1 infection and before general changes in immune status are apparent. Such changes could be indicative of developing lesions in specific immune function and could contribute to the high incidence of clinical CMV infection in HIV+ subjects.

Keywords: AEGIS, Cytomegalovirus, HIV Infections, Cytomegalovirus Infections, HIV, HIV-1, Acquired Immunodeficiency Syndrome, Homosexuality, HIV Antibodies, HIV Seroprevalence, Immunoglobulin G, AIDS-Related Complex, Adult, ICA7KWDaegis,cytomegalovirus,hivinfections,cytomegalovirusinfections,hiv,hiv-1,acquiredimmunodeficiencysyndrome,homosexuality,hivantibodies,hivseroprevalence,immunoglobuling,aids-relatedcomplex,adult,ica7
910616
MA30

Copyright © 1991 - International AIDS Society (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the IAS.